Cytochrome P450 enzyme
Osteomalacia in an HIV-infected man receiving rifabutin, a cytochrome P450 enzyme inducer: a case report
... and cytochrome P450 mediated drug effects. Cytochrome P450 enzyme inhibition is indicated by broken lines and stimulation by solid ...of enzyme inhibition or stimulation is ...
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Pharmacokinetic and Pharmacodynamics Interaction between Syzygium cumini and Glipizide: Role of Cytochrome P450 Enzyme
... Background: Concomitant administration of herbs and synthetic drugs causes pharmacokinetic and pharmacodynamic interactions. Objectives: To investigate pharmacokinetic and pharmacodynamic interactions between Syzygium ...
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Original Article Effects of suberoylanilide hydroxamic acid on rat cytochrome P450 enzyme activities
... In conclusion, continuous intragastric adminis- tration of SAHA for 7 days may induce the activ- ities of CYP450 isoforms CYP2C19 of rats, inhibit the activity of CYP1A2, and may slight inhibit the activity of CYP2D6 and ...
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Bioluminescent Cytochrome P450 Assays
... P450 enzyme inhibition was measured using P450-Glo TM Screening Systems (Promega ...human cytochrome P450 enzyme, control membranes devoid of P450 activity, a luminogenic ...
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Clinical significance of pharmacogenomic studies in tardive dyskinesia associated with patients with psychiatric disorders
... between cytochrome P450 enzyme-determined poor metabolizer status and elevated serum antipsychotic and metabolite ...of cytochrome P450 enzyme, dopamine (receptor, metabolizer ...
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A microarray based system for the simultaneous analysis of single nucleotide polymorphisms in human genes involved in the metabolism of anti malarial drugs
... metabolizing enzyme genes, microarray determined SNPs were compared with ...human cytochrome P450 enzyme family (CYP) and N-acetyltransferase-2 (NAT2) involved in anti- malarial drug ...
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Activation of CD8+ T-Cell with abacavir and HLA-B*57:01 binding peptides and elimination of T-Cell responses through chemical modification
... Abacavir Adverse drug reaction Antigen presenting cell Counts per minute Cyclosporin Cytochrome P450 enzyme Damage associated molecular pattern Dendritic cell Drug hypersensitivity react[r] ...
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Polydrug abuse among opioid maintenance treatment patients is related to inadequate dose of maintenance treatment medicine
... CYP: Cytochrome P450 enzyme; DSM-IV: Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition; EMCDDA: European Monitoring Centre for Drugs and Drug Addiction; GC-MS: Gas chromatography ...
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Improving the production of 22-hydroxy-23,24-bisnorchol-4-ene-3-one from sterols in Mycobacterium neoaurum by increasing cell permeability and modifying multiple genes
... To further improve the production of the target intermediate 4-HBC, four genes, including choM1 , choM2 , a cyp125 gene encoding a cytochrome P450 enzyme [ 25 , 26 ] and a fadA5 [r] ...
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Interaction between Meropenem and Valproate: Not to overlook
... Valproic acid an antiepileptic drug is metabolized mainly by liver (cytochrome P450 enzyme system mainly by glucronidation) and its metabolites are removed by kidneys (Bauer, 2005; Gugler & ...
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Activation of peroxisome proliferator activated receptor alpha ameliorates ethanol induced steatohepatitis in mice
... Ethanol treatment results in fatty acids accumulation in the liver. Fatty acids are substrate of cytochrome P450 2E1 (CYP 2E1). Induction of CYP 2E1 by fatty acids is a major source of reactive oxygen ...
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Genetic variation in the CYP2B6 Gene is related to circulating 2,2’,4,4’-tetrabromodiphenyl ether (BDE-47) concentrations: an observational population-based study
... found in the general human population. However, if BDE-47 can induce CYP2B6 enzymes also at lower concentration, this will have implications on human response to numerous therapeutic drugs [39]. There is also evidence ...
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Management of HIV-associated tuberculosis in resource-limited settings: a state-of-the-art review
... of cytochrome P450 2B6 (CYP2B6), which comprises the main meta- bolic pathway for EFV, studies have failed to demon- strate significantly reduced concentrations of EFV with concomitant RIF-based TB ...
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Towards the development of selective hydrocarbon oxygenation catalysts
... like cytochrome P-450 and bacterial methane monooxygenase contain their active iron sites embedded within a deeply hydrophobic region of the protein enabling the ready uptake, correct orientation and subsequent ...
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EFFECTS OF CURCUMIN ANALOGUE, 2, 6-BIS (2, 5-DIMETHOXYBENZYLIDENE) CYCLOHEXANONE (BDMC33) ON THE ACTIVITIES OF DRUG-METABOLIZING ENZYMES IN CULTURED CACO-2 CELL MODEL
... The current study also demonstrated that Caco-2 cells treated with curcumin had their UGT activities increased but was not differed significantly, compared to untreated one. However, UGT activities in Caco-2 treated with ...
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Previously claimed male germline stem cells from porcine testis are actually progenitor Leydig cells
... TIN), cytochrome P450 family 11 subfamily A member 1 (CYP11A1), cytochrome P450 family 17 subfamily A member 1 (CYP17A1), steroidogenic acute regulatory protein (StAR), and β hydroxysteroid ...
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Engineering of daidzein 3’-hydroxylase P450 enzyme into catalytically self-sufficient cytochrome P450
... CYP enzyme with Soret peak at 419 nm, an α-band at 567 nm, and and unresolved β- band due to the overlap with a broad shoulder in the 440–490 nm ...fusion enzyme used NADPH preferably (approximately 500 ...
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The planetary biology of cytochrome P450 aromatases
... A complete maximum likelihood analysis of the aro- matase gene family was performed using the PAUP and PAML programs. The resulting tree, generated in PAUP, is shown in Figure 5, with parameters estimated using PAML. ...
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Cytochrome P450 Biocatalysts: A Route to Bioremediation
... cytochromes P450 (CYPs) are key enzymes in the metabolization of all xenobiotics by catalyzing oxidations of the substrate and are polymorphic in ...nature. Cytochrome P450 genes constitute one of ...
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Identification of reliable reference genes for quantitative real-time PCR normalization in pitaya
... To the best of our knowledge, this study is the first report on systematically evaluating the expression sta- bility of different potential reference genes for qRT-PCR in the Cactaceae family. Thirty-nine typical ...
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