Cytotoxic T Lymphocyte (CTL)
The neurotrophic hepatocyte growth factor attenuates CD8+ cytotoxic T-lymphocyte activity
... + T cell func- tions we used an established in vitro model of cytotoxic T-cell-dependent ...effector cytotoxic gp100-petide T cell receptor (Pmel-1) CD8 + T cells from naïve ...+ ...
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Tissue Dimensionality Influences the Functional Response of Cytotoxic T Lymphocyte-Mediated Killing of Targets
... Cytotoxic T lymphocyte (CTL)-mediated killing of virus infections and tumors occurs over a wide range of ...(3D) T cell areas within lymphoid ...
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Quantitative study of cytotoxic T-lymphocyte immunotherapy for nasopharyngeal carcinoma
... infuse cytotoxic T-lymphocyte (CTL) lines several times by intravenous injection, but it is difficult by laboratory research to investigate the relationship between treatment time-point, the amount ...
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Common Antiviral Cytotoxic T-Lymphocyte Epitope for Diverse Arenaviruses
... Members of the Arenaviridae family have been isolated from mammalian hosts in disparate geographic locations, leading to their grouping as Old World types (i.e., lymphocytic choriomeningitis virus [LCMV], Lassa fever ...
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Papillomavirus Pseudovirus: a Novel Vaccine To Induce Mucosal and Systemic Cytotoxic T-Lymphocyte Responses
... Intestinal mucosa is a portal for many infectious pathogens. Systemic immunization, in general, does not induce a cytotoxic T-lymphocyte (CTL) response at the mucosal surface. Because papillomavirus ...
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Cytotoxic T lymphocyte responsiveness after resolution of chronic hepatitis B virus infection
... specific cytotoxic T lymphocyte (CTL) response to HBV (2-6) that lasts for decades following recovery, which is probably maintained by traces of virus that persist indefinitely after clin- ical and ...
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Correlation of Major Histocompatibility Complex Class I Downregulation with Resistance of Human T-Cell Leukemia Virus Type 1-Infected T Cells to Cytotoxic T-Lymphocyte Killing in a Rat Model
... Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia (ATL) in infected individuals after a long incubation ...Tax-specific cytotoxic T-lymphocyte (CTL) lines from ...
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Induction of vigorous cytotoxic T-lymphocyte responses by live attenuated simian immunodeficiency virus.
... examined cytotoxic T-lymphocyte (CTL) responses against SIV in animals infected with SIVmac239 D nef (deficient in nef) or SIVmac239 D 3 (deficient in nef, vpr, and upstream sequences in ...
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The cytotoxic T-lymphocyte response to Sendai virus is unimpaired in the absence of gamma interferon.
... virus-specific cytotoxic T-lymphocyte (CTL) activity in the cell population recovered by bronchoalveolar lavage is unimpaired, the prevalence of interleukin-4 (IL-4)-producing cells is increased, and ...
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The monoclonal antibody to cytotoxic T lymphocyte antigen 4, ipilimumab, in the treatment of melanoma
... of cytotoxic T-lymphocyte antigen-4 (CTLA-4) and its role as a key negative regulator for T-cells have led to the approval of ipilimumab as a new approach to treat unresectable ...the ...
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Prospective study of cytotoxic T lymphocyte responses to influenza and antibodies to human T lymphotropic virus III in homosexual men Selective loss of an influenza specific, human leukocyte antigen restricted cytotoxic T lymphocyte response in human T lymphotropic virus III positive individuals with symptoms of acquired immunodeficiency syndrome and in a patient with acquired immunodeficiency syndrome
... Peripheral blood leukocytes (PBL) from 18 homosexual men who did not have acquired immunodeficiency syndrome (AIDS) and from 9 heterosexual men were repetitively tested for their ability to generate HLA self-restricted ...
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Anti-cytotoxic T lymphocyte antigen-4 antibodies in melanoma
... the T-cell receptor by the major histocompatibility complex class I or II molecules on an antigen presenting ...the T-cell to B7 molecules on the antigen presenting ...of cytotoxic T ...
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Cytotoxic T lymphocyte antigen 4 and immune checkpoint blockade
... Cytotoxic T lymphocyte antigen-4 (CTLA-4) is a regulatory molecule that suppresses T cell effector function following initial activation by costimulatory ...increase T cell function and ...
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Intracellular Hepatitis B Virus Nucleocapsids Survive Cytotoxic T-Lymphocyte-Induced Apoptosis
... FIG. 1. HBsAg-specific CD8-positive T-cell clone (6C2) induces apoptosis in HBV-transgenic hepatocytes. Chromosomal DNA was prepared from pools of adherent and nonadherent cells and debris from untreated ...
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Prediction and identification of mouse cytotoxic T lymphocyte epitopes in Ebola virus glycoproteins
... To further confirm RF was a specific CTL CD8 + epi- tope, BALB/c mice were immunized with Ad5-GPS or control (Ad5-EGFP) twice with an interval of 4 weeks. At 10 days after the second immunization, splenocytes were ...
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Effective Cytotoxic T Lymphocyte Targeting of Persistent HIV 1 during Antiretroviral Therapy Requires Priming of Naive CD8+ T Cells
... ⫹ T cells that se- crete proinflammatory factors in the absence of CTL killing could promote viral replication following antigen ...ory T cells that are specific for variants of the immunotherapeutic ...⫹ ...
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Epitope-Dependent Avidity Thresholds for Cytotoxic T-Lymphocyte Clearance of Virus-Infected Cells
... CTL T-cell receptors (TCRs) trigger these functions when they specifically bind infected cell surface viral epitope/HLA class I molecule complexes. These are produced after trans- lated viral proteins are ...
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Antiviral Antibodies Are Necessary To Prevent Cytotoxic T-Lymphocyte Escape in Mice Infected with a Coronavirus
... mice, while they diminish in BALB/b mice (Fig. 3D and E). In the absence of an anti-JHMV antibody response, CTL escape at epitope S510 is detected in all mice (Tables 1 and 2 and Fig. 4). This high rate of CTL escape is ...
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Simian virus 40 T antigen as a carrier for the expression of cytotoxic T-lymphocyte recognition epitopes.
... The results show that the translocated SV40 T antigen site I and the HSV gB CTL epitopes in the chimeric T antigens, when expressed in immortalized C57BL/6 B6 mouse kidney cells, were ef[r] ...
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Polyomavirus DNA is damaged in target cells during cytotoxic T-lymphocyte-mediated killing.
... These results suggest that the fate of viral DNA during CTL-mediated lysis corresponds to the fate of the host cell DNA; that is, in cells which undergo extensive doublestranded DNA frag[r] ...
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