Cytotoxic T-lymphocytes (CTL)
Recognition of clonogenic leukemic cells, remission bone marrow and HLA identical donor bone marrow by CD8+ or CD4+ minor histocompatibility antigen specific cytotoxic T lymphocytes
... antigen-specific cytotoxic T lymphocytes (CTL) can discriminate between leukemic hematopoietic progenitor cells (leukemic-HPC) from AML or CML patients, the HPC from their remission bone ...
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Dengue virus protein recognition by virus-specific murine CD8+ cytotoxic T lymphocytes.
... We studied the recognition by murine dengue virus-specific major histocompatibility complex class I-restricted, CD8+ cytotoxic T lymphocytes CTL of dengue virus proteins using recombinan[r] ...
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Efficient lysis of human immunodeficiency virus type 1-infected cells by cytotoxic T lymphocytes.
... (HIV-1)-specific cytotoxic T lymphocytes (CTL) have examined their ability to recognize B-cell lines expressing recombinant HIV-1 proteins, but relatively few data regarding the lysis of ...
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Cytotoxic T lymphocytes form an antigen independent ring junction
... in CTL- mediated killing are associated with failure to destroy some immunogenic tumors and virally infected ...Activated T cells hunting for antigenic MHCp com- plexes are attracted to peripheral tissues ...
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CD40 Ligand-Mediated Interactions Are Involved in the Generation of Memory CD8+ Cytotoxic T Lymphocytes (CTL) but Are Not Required for the Maintenance of CTL Memory following Virus Infection
... effector CTL activity mediated by each test population was also ...tor CTL activity exhibited by CD40L-deficient and control mice was indistinguishable ...direct CTL lysis were not as high and the ...
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Kinetics of Antiviral Activity by Human Immunodeficiency Virus Type 1-Specific Cytotoxic T Lymphocytes (CTL) and Rapid Selection of CTL Escape Virus In Vitro
... specific CTL-mediated cytolysis, first observed well before peak virus production, indicate that CTL may prevent a sig- nificant quantity of virus from being ...Env-specific CTL- mediated lysis of ...
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The combination of dendritic cells-cytotoxic T lymphocytes/cytokine-induced killer (DC-CTL/CIK) therapy exerts immune and clinical responses in patients with malignant tumors
... numerates lymphocytes both in tumor center (CT) and invasive margin (IM), has been intro- duced to add to the significance of the American Joint Committee on Cancer (AJCC)-Union for International Cancer Control ...
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Effects of Cytotoxic T Lymphocytes (CTL) Directed against a Single Simian Immunodeficiency Virus (SIV) Gag CTL Epitope on the Course of SIVmac239 Infection
... CM9-specific CTL responses detected during the acute phase of infection in SIVmac239-infected macaques ...CM9-specific CTL were not boosted (both animals showed an increase to only ...CM9-specific ...
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Normal self proteins as targets for tumour specific cytotoxic T lymphocytes (CTL)
... by CTL do not induce immune ...induce CTL despite expressing high levels o f a defined tum our antigen, the human papillomavirus protein ...of CTL able to recognise both the B7-1 positive and B7-1 ...
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The human cytotoxic T-lymphocyte (CTL) response to cytomegalovirus is dominated by structural protein pp65: frequency, specificity, and T-cell receptor usage of pp65-specific CTL.
... Cytotoxic T lymphocytes (CTL) appear to play an important role in the control of human cytomegalovirus (HCMV) in the normal virus carrier: previous studies have identified peripheral blood CD8 ...
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Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes
... memory T cells, respectively; while the IL-15–treated cells were capable of migration into peripheral lymph nodes, the IL-2–treated cells were selectively excluded from lymph nodes, but homed pref- erentially to ...
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Enhanced presentation of MHC class Ia, Ib and class II restricted peptides encapsulated in biodegradable nanoparticles: a promising strategy for tumor immunotherapy
... Methods: To address this issue, we have engineered polylactic-co-glycolic acid (PLGA) nanoparticles incorporating: (i) two MHC class I-restricted clinically-relevant peptides, (ii) a MHC class II-binding peptide, and ...
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Vaccinia virus-specific CD8+ cytotoxic T lymphocytes in humans.
... After infection with vaccinia virus, the 10% infected, gamma-irradiated autologous PBMC and the 90% uninfected, gamma-irradiated autologous feeder PBMC were combined and resuspended to 1[r] ...
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Persistence of vesicular stomatitis virus in cloned interleukin-2-dependent natural killer cell lines.
... Cloned lines of H-2-restricted hapten- or virus-specific cytotoxic T lymphocytes CTL and alloantigen-specific CTL were resistant to productive infection by vesicular stomatitis virus VSV[r] ...
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Memory and distribution of virus-specific cytotoxic T lymphocytes (CTLs) and CTL precursors after rotavirus infection.
... 65, 1991 tinal and nonintestinal lymphocytes after rotavirus infection, adult mice were inoculated orally or via the hind footpad with RRV; virus-specific cytotoxic activities in intesti[r] ...
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Virotheranostics, a double-barreled viral gun pointed toward cancer; ready to shoot?
... class-I; CTL: Cytotoxic T-lymphocytes; PRRs: Pattern recognition receptors; SPECT: Sin- gle-photon emission computed tomography; OMV: Oncolytic measles virus; NIS: Sodium iodide Symporter; ...
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<p>T cells targeting multiple tumor-associated antigens as a postremission treatment to prevent or delay relapse in acute myeloid leukemia</p>
... c cytotoxic T lymphocytes (CTLs) originated from the relapse of chronic myeloid leukemia (CML) after donor lymphocyte infusion (DLI) treatment by allogeneic HSCT, followed by selective component ...
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HLA dependent tumour development: a role for tumour associate macrophages?
... and cytotoxic T lymphocytes function while HLA-G induces the secretion of pro-angiogenic cytokines and chemokine thanks to an activator KIR receptor expressed by a minority of peripheral NK ...
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Tumor escape from immune recognition: lethal recurrent melanoma in a patient associated with downregulation of the peptide transporter protein TAP 1 and loss of expression of the immunodominant MART 1/Melan A antigen
... by T cells have been identified on human ...nodominant T cell–defined MART-1/Melan-A antigen and downregulation of the TAP-1 gene in a recurrent metastatic melanoma that was resected in ...
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Targeting the inflammation in HCV associated hepatocellular carcinoma: a role in the prevention and treatment
... hepatic T cells are either CD4+ or double negative (CD4-CD8-) and express receptors typi- cal of both NK cells (CD16+, CD56+, CD161+) and T- cells (T-cells receptors, ...conserved T-cell ...
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