DEAD-box protein 3
Unexpected roles for DEAD box protein 3 in viral RNA sensing pathways
... From these findings, the authors propose a model in which DDX3 serves as an initial sensor of RNA in unstimulated cells and that DDX3 intensifies signalling from IPS-1 when expression levels of RIG-I are low (Figure 1). ...
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The DEAD box RNA helicase Vasa functions in embryonic mitotic progression in the sea urchin
... We surveyed the cell-cycle-dependent Vasa localization in other echinoderms and found that Vasa protein was localized in the nuclear region of cells in M phase with a strong morphological Fig. 3. The Vasa C ...
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Conserved requirement for DEAD box RNA helicase Gemin3 in Drosophila oogenesis
... Ovaries of female flies, which were fed on wet yeast for ~3 days in the presence of males, were dissected in PBS (phosphate buffered saline) at room temperature and later fixed in 4% paraformaldehyde in PBS. The ...
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The DEAD box RNA helicase Vad1 regulates multiple virulence associated genes in Cryptococcus neoformans
... virulence-associated DEAD-box RNA helicase–encoding gene (VAD1) was isolated from a mutant defective in the virulence fac- tor ...identify 3 additional virulence determinants dependent on VAD1: PCK1, ...
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A HIV 1 Tat mutant protein disrupts HIV 1 Rev function by targeting the DEAD box RNA helicase DDX1
... acid protein and can be divided into three discrete function ...Rev:RRE protein complex [also called Rev ribonucleoprotein (RNP) complex] requires the recruitment of multiple Rev monomers ...shuttling ...
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The Sole DEAD Box RNA Helicase of the Gastric Pathogen Helicobacter pylori Is Essential for Colonization
... multiple DEAD-box helicases, one or more are required for proper ribosome ...4 DEAD-box helicases ...RhpA protein pool to individual ribosome subunits (30S and ...
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DEAD box helicase DP103 defines metastatic potential of human breast cancers
... nuclear and receptor-mediated NF-κB activation, which works by phosphorylating the Ser180/Ser181 in the activation loop of IKKs (39, 40, 44). We first investigated whether endogenous DP103 and TAK1 interact. Indeed, ...
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Involvement of a Toxoplasma DEAD-box RNA Helicase in Post-transcriptional Gene Regulation
... The observation that in extracellular parasites TgHoDI colocalizes with mRNA granules led us to identify whether these structures are involved in mRNA degradation or translational repression. IFA analysis was employed to ...
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DDX3 DEAD-Box RNA Helicase Is Required for Hepatitis C Virus RNA Replication
... On the other hand, DDX3 binds to the hepatitis C virus (HCV) core protein (17, 19, 25), and DDX3 expression is deregulated in HCV-associated hepatocellular carcinoma (HCC) (7, 8). However, the biological function ...
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DEAD box protein p68 is regulated by β catenin/transcription factor 4 to maintain a positive feedback loop in control of breast cancer progression
... Sonicated cross-linked chromatin fragments were pre- pared from cells treated with formaldehyde as described earlier [41,42]. Briefly, equal amounts of all pre-cleared chromatin fragments (250 μg) were incubated with ...
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Alterations in the expression of DEAD box and other RNA binding proteins during HIV 1 replication
... The DEAD box proteins, a family of RNA helicases con- taining the conserved amino acid motif Asp-Glu-Ala-Asp (D-E-A-D in the single letter amino acid code), play an essential role in many aspects of ...
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Ovarian germline stem cells
... the isolation of fGSCs from adult mice. Using a magnet- ically activated cell sorting technique, the authors iso- lated putative fGSCs measuring 12 to 20 μm in diameter by using an antibody against either DDX4 ...
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Study the Behavior of the Trapezoidal PSC Box Girder by using Single and Double Cell with the Help of IRC and AASHTO Codes
... preferred box girder bridges instead of regular bridges, where prestress box girder is most suitable option because of its economy, stability, structural efficiency and ...PSC box girder bridge by ...
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An immune stratification reveals a subset of PD 1/LAG 3 double positive triple negative breast cancers
... Even though the immune system can recognize and eliminate malignant cells, tumors have developed mul- tiple mechanisms to evade effective immunosurveillance, including the activation of the immune checkpoints PD- 1 and ...
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A Data Embedding Scheme using Encrypted Images
... A test image in Gray scale sized 100*100*3 was first used as the cover image shown in figure 4.2 (a). After Image Encryption, all the 8 bits of each pixel of the three colours were converted into another value to ...
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A case of Metaplastic atrophic gastritis in immune Dysregulation, Polyendocrinopathy, Enteropathy, X-linked (IPEX) syndrome
... of 3 years and 11 ...to 3 years of life. At the age of 3 years, whole protein formula was introduced in his ...whole protein formula and reintroduced amino acid formula in his ...
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Regulation of Notch Signaling by an Evolutionary Conserved DEAD Box RNA Helicase, Maheshvara in Drosophila melanogaster
... fusion protein was used for generating the anti- ...fusion protein, the N-terminal region of Mahe was PCR amplified using forward primer 59-CGCAGGAATTCATGTTCGCTGGAGCATATG-39 with EcoRI and reverse primer ...
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Effects of intensity and frequency of defoliation on a mixture of guinea grass (Panicum maximum cv Coloniao) and Verano stylo (Stylosanthes hamata cv Verano) : a thesis presented in partial fulfilment of the requirements for the degree of Master of Agricultural Science in Plant Science at Massey University
... Effects of defoliation intensity and frequency on crude protein yield of grass, grass leaf, dead material and percent crude protein content of grass, grass leaf, grass non-leaf, dead mat[r] ...
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The 'family-nurse partnership' : developing an instrument for identification, assessment and recruitment of clients
... 114.2. All the professionals involved need to show that they are proud of what they can offer. The commitment and enthusiasm of the midwives, the other staff at the Booking Clinic and the managers will be crucial. They ...
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Identification of the DEAD box RNA helicase DDX3 as a therapeutic target in colorectal cancer
... Apart from several studies finding an oncogenic role of DDX3 in cancer [3, 4, 6, 17–22], others have suggested that DDX3 may also have a tumor suppressive role in certain cancers. [23–26] Although it is difficult ...
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