dendritic cell
Schnorfeil, Frauke Marie (2011): MicroRNAs regulate Dendritic Cell Development and Function. Dissertation, LMU München: Medizinische Fakultät
... While pDCs and cDCs share common progenitors (section 4.1.2), pDCs possess distinct mo- lecular features resembling those of lymphocytes. pDCs are also called natural interferon- producing cells, as they produce massive ...
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Dendritic cell tumor in a salivary gland lymph node: a rare differential diagnosis of salivary gland neoplasms
... In summary, we report on the clinical, pathologic, and immunohistochemical features of a dendritic cell tumor, NOS in an intraparotideal lymph node. Metastatic dis- ease was ruled out by PET- and CT ...
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Randomized phase II trial of autologous dendritic cell vaccines versus autologous tumor cell vaccines in metastatic melanoma: 5-year follow up and additional analyses
... Since MACVAC was conducted, enzyme-targeted BRAF inhibitors and monoclonal antibody immune checkpoint inhibitors, have become standard therapies for patients with metastatic melanoma, and are associated with im- proved ...
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The dendritic cell algorithm for intrusion detection
... Systems, Dendritic Cell Algorithm, Danger Theory, Intrusion Detection, Botnet, Signal, Antigen, Deterministic DCA, Negative Selection, Segmentation, Correlation Coefficient, Information Gain, Principal ...
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Deficient Natural Killer Dendritic Cell Responses Underlay the Induction of Theiler's Virus Induced Autoimmunity
... T cell-mediated autoimmune demyelinating disease multiple ...killer dendritic cell (NKDC), which was shown to play a critical role in early CNS virus clearance via its ability to both present virus ...
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Dendritic Cell Autophagy Contributes to Herpes Simplex Virus Driven Stromal Keratitis and Immunopathology
... Consistent with previous reports (37–39, 47), we found that DC-autophagy has a significant impact on the development of adaptive immunity, specifically CD4 ⫹ T cell responses. DC- autophagy was also reported to ...
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Dendritic cell-derived nitric oxide inhibits the differentiation of effector dendritic cells
... Dendritic cells (DCs) play a pivotal role in the development of effective immune defense while avoiding detrimental inflammation and autoimmunity by regulating the balance of adaptive immunity and immune ...
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Dendritic cell regulation of B cells
... upon cell lysis (11, 13, 14, ...B cell tolerance remains unclear; however, the strength of the BCR signal and the availability, and/or location of antigen directly affects the differentiation of ...
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Effect of dendritic cell cytokine induced killer cells in patients with advanced colorectal cancer combined with first line treatment
... recent cell-based therapeutic ...before cell transfusion can enhance anti-tumor effects in previous clinical studies ...T cell activation during cell therapies ...
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Dendritic cell defects in Wiskott-Aldrich Syndrome
... WAS is an X-linked recessive disorder characterised by the clinical triad o f eczema, thrombocytopoenia and recurrent infections (MIM 301 000). The incidence in the U.S.A. is estimated at 4 per million live male births ...
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Deletion of the Virion Host Shutoff Protein (vhs) from Herpes Simplex Virus (HSV) Relieves the Viral Block to Dendritic Cell Activation: Potential of vhs− HSV Vectors for Dendritic Cell-Mediated Immunotherapy
... Herpes simplex virus (HSV) infects dendritic cells (DC) efficiently but with minimal replication. HSV, therefore, appears to have evolved the ability to enter DC even though they are nonpermissive for virus ...
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Murine Cytomegalovirus Spreads by Dendritic Cell Recirculation
... How LN infection leads to a myeloid cell-associated viremia is unclear. Productive LN infection might shed virions into the efferent lymph for capture by vasculature- associated myeloid cells, but no corresponding ...
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Dendritic Cell Therapy of Primary Brain Tumors
... Effective treatment of intracerebral glioma with DC was also shown in the experimental rat 9L gliosarcoma model (33). Starting one week after in- tracranial tumor implantation, the animals received three weekly s.c. ...
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Molecular Mechanisms of Dendritic Cell Dendrite Formation
... Interestingly, structures reminiscent o f FAs were observed at the points o f adhesion between the DC dendrite and FN. FAs are sites where bundles o f actin filaments are anchored to integrins via a multimolecular ...
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Molecular signatures of maturing dendritic cells: implications for testing the quality of dendritic cell therapies
... The genes up-regulated during DC maturation included many involved with immune function, cell dif- ferentiation, and migration. Several chemokines and their ligands were up-regulated during maturation. For exam- ...
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The role of MerTK and BAFF in dendritic cell-B cell interactions
... refractory to LPS-induced NF-κB activation [31]. Since others have shown that apoptotic cells can induce BAFF surface expression on DC [200, 205] we next wanted to see how apoptotic cells affected BAFF expression by ...
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CSF 1 signaling mediates recovery from acute kidney injury
... macrophage/dendritic cell depletion prior to induc- tion of renal epithelial apoptosis resulted in markedly increased and prolonged neutrophil infiltration (Figure ...
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Anti HER2 CD4+ T helper type 1 response is a novel immune correlate to pathologic response following neoadjuvant therapy in HER2 positive breast cancer
... Utilizing a prospective cohort, we have recently demon- strated a progressive loss in anti-HER2 CD4 + T-helper type-1 (Th1) immunity across a tumorigenesis continuum in HER2 pos BC [10]. Interestingly, HER2-specific Th1 ...
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Virus-specific antigen presentation by different subsets of cells from lung and mediastinal lymph node tissues of influenza virus-infected mice.
... T cell and generate a virus-specific CTL are not well ...and dendritic cells are all considered profes- sional APC, dendritic cells have been shown to have the ca- pacity to generate an ...
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Estrogen: A Novel Therapeutic Adjunct for the Treatment of Trauma-Hemorrhage—Induced Immunological Alterations
... splenic dendritic cell antigen presentation capacity, MHC class II expression, LPS-induced IL-12 production, and LPS- or IL-12–induced IFN-γ production were observed after trauma-hemorrhage ...Kupffer ...
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