Development of anti-cancer Drug
Comparison of responsiveness to cancer development and anti-cancer drug in three different C57BL/6N stocks
... the development of immunotherapy and targeted ...to anti-cancer drugs in the syngeneic model by evaluating survival, growth of tumors, proliferation and molecular biology ...to ...
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Chemoresistance of Cancer Cells: Requirements of Tumor Microenvironment-mimicking In Vitro Models in Anti-Cancer Drug Development
... efficacious drug candidates might be eliminated during early screening, and compounds with lower or no clinical efficacy might progress into clinical trials, resulting in increased developmental cost and ...vitro ...
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Surface-modified cobalt oxide nanoparticles: new opportunities for anti-cancer drug development
... has anti-cancer activity; rather than they have no adverse effect on normal ...new anti-cancer drug development ...generation drug development. In vivo testing of ...
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A VALIDATED STABILITY INDICATING RP-HPLC METHOD DEVELOPMENT FOR ANTI CANCER DRUG ENZALUTAMIDE IN BULK AND PHARMACEUTICALS
... of drug were ...with drug peak. From the chromatogram it was observed that 3.10% of drug was degraded in ...the drug percentage degradation was ...days. Drug under UV- chamber for ...of ...
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Molecular chess? Hallmarks of anti cancer drug resistance
... the development of cancer and was an important resistance mechanism for cancer cells to both chemotherapy [8, 47, 48] and agents targeting signaling pathways ...by anti-cancer drugs, ...
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ELECTROCHEMICAL OXIDATION AND DETERMINATION OF AN ANTI CANCER DRUG PEMETREXED DISODIUM
... the development of modern computer based electrochemical instrumentation, electroanalytical techniques, especially modern pulse technique, such as differential pulse voltammetry (DPV) have been used for the ...
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Role of Biomarkers in Cancer Research and Drug Development
... the cancer is a flexible disease and consists of various types with different biological behaviour, molecular and risk ...the cancer requires different factors such as prognostic and predictive factors for ...
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LESS TOXIC NANOPARTICLES OF PLATINUM BASED ANTI CANCER DRUG
... a drug or other active agent to release the drug in a pre-designed manner 1, 37 ...The development of Novel drug delivery system has been made possible by the various compatible polymers to ...
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Evaluation of Anti Oxidant Status and Radioprotective Activity of a Novel Anti Cancer Drug in Mice
... necessitated development of a ra- dioprotector to safeguard against human ...the development of nontoxic and effective radiopro- tectants that can reduce the effect of ionizing radiation ...
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Targeted drug delivery of anti cancer drug by applying gastro retentive systems and its pharmacological evaluation.
... the development of controlled release drug delivery ...release drug delivery systems (CRDDS) are designed to release one or more drugs continuously in a predetermined pattern for a fixed period of ...
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Cancer epigenetics drug discovery and development: the challenge of hitting the mark
... Epigenetic drug discovery may be viewed as being in its infancy, as we are just beginning to understand the complexities of the “histone code” and the effects of pharmacological ...tools, drug discovery ...
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Noncoding RNAs in cancer therapy resistance and targeted drug development
... breast cancer [84, ...lung cancer xenograft model, highlighting the potential of MALAT1 as a therapeutic target in multiple tumors ...natural anti- sense RNAs (NATs) are sometimes located near ...
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Clinical development of targeted and immune based anti-cancer therapies
... the development of T-DM1 [193]. T-DM1 is an ADC that consists of the drug DM1 (a tubulin inhibitor) bound to trastuzumab ...of anti-cancer drugs, which have demonstrated marked toxicity and ...
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Liposomes encapsulating cyclodextrin enclosed hydrophobic anti-cancer drugs: a novel drug delivery system for cancer.
... the cancer. The second highest deaths were noticed by the cancer in ...the cancer but not found much efficient. The advance development in the hydrophobic drug in the form of ...
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Biology-driven cancer drug development: back to the future
... of cancer drug development [1] and so here we will only pick out the salient ...treating cancer with drugs emanated from the observation that exposure to chemical warfare agents (‘poison ...
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DEVELOPMENT AND EVALUATION OF NANOCARRIERS OF AN ANTICANCER DRUG FOR THE TREATMENT OF BREAST CANCER
... for cancer which are effective and ...conventional anti-cancer drugs, including increased solubility, bioavailability, protection against toxicity, enhanced pharmacological activity, improved ...
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A screen to identify drug resistant variants to target-directed anti-cancer agents
... the development of target- specific small molecule anti-cancer ...of drug resistance due to amino acid substitutions in the target ...a drug-target pair, we recently reported a ...
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Anticancer Effect of Metformin, an anti diabetic drug, on breast Cancer Cells
... The cells obtained after trypsinization and proper dilution with EMEM buffer were then properly mixed and 100µl of the solution containing the cells were aseptically inoculated in 90 well MTT plate and were incubated ...
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Evaluation of Anti Diabetic Drug Alogliptin for the Treatment of Cancer in Rats
... of cancer control group show disorganized hepatic parenchyma with trabeculae of polyhedral cells bordering wide sinusoids which represent cellular necrosis and hepatocellular carcinoma development by ...
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Cancer immunotherapy trials: leading a paradigm shift in drug development
... host anti-tumor immunity [9]. The clinical development of T-VEC in metastatic melanoma required considerable thought to define the eligible pa- tient population, which required accessible tumor for direct ...
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