di-methylation
DNA Replication Origin Function Is Promoted by H3K4 Di-methylation in Saccharomyces cerevisiae
... mono-, di-, and tri-methylation of H3K4. These methylation states are differentially distributed over gene bodies (Pokholok et ...ent methylation states of H3K4 and H3K36 can have differ- ent ...
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Setdb1-mediated H3K9 methylation is enriched on the inactive X and plays a role in its epigenetic silencing
... (H3K9) methylation is more controversially associated with the inactive X, based on a series of immunofluorescence ...H3K9 di- methylation (H3K9me2) was ostensibly found on the Xi from the earliest ...
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Schmähling, Sigrun (2019): Biochemical purification and functional characterization of a novel trithorax-group protein complex. Dissertation, LMU München: Fakultät für Biologie
... The trithorax group (trxG) of genes encodes diverse transcriptional regulators that play a pivotal role in development of animals and plants. The characteristic property of trxG proteins is to maintain active ...
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Experimental acute lung injury induces multi organ epigenetic modifications in key angiogenic genes implicated in sepsis associated endothelial dysfunction
... Multiplex chromatin immunoprecipitation platform Matrix ChIP analysis of changes in repressive histone H3 lysine 9 di-methylation H3K9m2 at Angpt1, Tek, Kdr, and Ngal genes in experiment[r] ...
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Role of NPR1 and KYP in long-lasting induced resistance by beta-aminobutyric acid
... H3K9 di-methylation and associated CpHpG DNA methylation are repressive mech- anisms of gene expression (Kass et ...DNA methylation is responsible for transmission of defense priming (Luna et ...
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KDM5B demethylates H3K4 to recruit XRCC1 and promote chemoresistance
... the methylation level of H3K4 in drug-resistant cells and -sensitive cells, and found that the overall methylation level of H3K4 especially di-methylation and tri- methylation levels ...
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Nivolumab in chemotherapy-resistant cervical cancer: report of a vulvitis as a novel immune-related adverse event and molecular analysis of a persistent complete response
... Particularly striking in comparison to the majority of (HPV-associated) cervical squamous cell carcin- omas within the reference collection was the rather flat copy number profile of our case, hinting at a po- tential ...
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Altered methylation of glucosylceramide synthase promoter regulates its expression and associates with acquired multidrug resistance in invasive ductal breast cancer
... protein expression by promoter methylation of GCS is not completely understood. To date, most studies have focused on the association with GCS and its downstream effectors. And many results have been obtained. ...
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DNA methylation study of fetus genome through a genome-wide analysis
... been used to enrich and capture methylated DNA frag- ments from blood and amniotic fluid samples for use in gene-specific DNA methylation studies on a genome wide scale. According to the manufacturer’s protocol of ...
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Original Article TIMP1 high expression or hypomethylation might prdict favorable overall survival in colon adenocarcinoma patients
... There was no difference between different total DNA methylation subgroups and 2-, 5-, and 10-year OS (Figure 4A-C). On account of high TIMP1 expression indicating poor OS in COAD patients, the methylation ...
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DNA methylation, epialleles and gene regulation: Insights from the honey bee
... differential methylation patterns in this organism are correlated with the establishment of two distinct castes, that of queen and worker, from identical genetic information (Lyko and Maleszka 2011; Kucharski et ...
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Riflessioni a margine della sentenza della Corte di giustizia nel caso AMP Antarctica: un approccio più morbido a favore degli Stati membri?
... documento di riflessione. Oltretutto, è stato deciso di adottare la decisione del 2016 secondo la pro- cedura ordinaria esattamente alla luce di tale valutazione, adducendo il fatto che la procedura ...
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What Do Studies of Insect Polyphenisms Tell Us about Nutritionally-Triggered Epigenomic Changes and Their Consequences?
... gene-body methylation and control of alternative splicing in the honeybee [7,8,10,40] and the ant ...DNA methylation and alternative splicing in the honeybee has recently been established by reducing the ...
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Association between long interspersed nuclear element-1 methylation levels and relapse in Wilms tumors
... LINE-1 methylation levels between WT samples from patients with and with- out relapse in this cohort, thus we applied the uni- and multivariate analyses with other prognostic factors (stage and histological risk ...
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Disturbo borderline di personalità e disturbo bipolare di tipo II: confronto delle dimensioni di personalità
... concetto di endofenotipo hanno consentito im- portanti cambiamenti concettuali nello studio della genetica delle patologie ...semplice di quella del ...borderline di personalità, il tratto elementare ...
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Combination of serum RASSF1A methylation and AFP is a promising non-invasive biomarker for HCC patient with chronic HBV infection
... RASSF1A methylation was significantly lower than that of the patients without RASSF1A ...RASSF1A methylation may originate in circulating tumor cells, which then leads to tumor ...
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Deep characterization of a common D4Z4 variant identifies biallelic DUX4 expression as a modifier for disease penetrance in FSHD2
... phenotype, while the clinical consequences of arrays 8 – 10 units are highly unpredictable and can also be found in the control population [16, 23]. Recently, several groups showed that for carriers of 7 – 10 unit D4Z4 ...
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Differenze di genere nei disturbi di personalità in un campione di pazienti psichiatrici ospedalizzati
... correzione di “bias” legati al “genere” nella diagnosi dei DPs rimane un processo complesso e difficile; i clinici dovrebbero essere molto cauti quando pongono diagnosi di DP Istrioni- co o Dipendente nelle ...
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Mono-allelic retrotransposon insertion addresses epigenetic transcriptional repression in human genome
... Generally, our results agree with previous reports that retrotransposons may repress gene expression through an epigenetic mechanism. Our study strongly supports the observations that young active retrotransposons insert ...
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Epigenomic analysis of lung adenocarcinoma reveals novel DNA methylation patterns associated with smoking
... DNA methylation with lung cancer-specific DNA methylation, we discovered 110 differentially methylated genes that were specifically associated with smoking-induced lung ...
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