Diabetic db/db mice
Comparison of Rosiglitazone and Metformin in Genetically Obese and Diabetic db/db Mice and Streptozotocin-Induced Diabetic Rat Models.
... in db/db mice and STZ-induced rat ...genetically diabetic db/db mice were orally administered with either rosiglitazone (5 mg/kg/day) or metformin (150 mg/kg/day) for 10 ...
8
Curcumin restores mitochondrial functions and decreases lipid peroxidation in liver and kidneys of diabetic db/db mice
... (+/+) mice, 85-, 58-, 27-, and 24-bp fragments in hetero- zygote (db/+) mice, and 58-, 27-, and 24-bp fragments in the diabetic (db/db) ...
8
The role of Na+/H+ exchanger in Ca2+ overload and ischemic myocardial damage in hearts from type 2 diabetic db/db mice
... both diabetic db/db and db/+ mice, and LVEDP increased (Figures 2, 3, ...in diabetic db/db hearts was significantly higher ...control db/+ hearts ...in ...
9
Combined effect of hyperfiltration and renin angiotensin system activation on development of chronic kidney disease in diabetic db/db mice
... of db/db mice, we treated them with ARB or the vasodilator hydralazine, which lowered blood pressure to levels similar to those observed in db sham mice without significant changes in ...
14
Saccharomyces boulardii Administration Changes Gut Microbiota and Reduces Hepatic Steatosis, Low Grade Inflammation, and Fat Mass in Obese and Type 2 Diabetic db/db Mice
... in db-Sb mice was associated with a marked decrease in liver macrophage infiltration markers, as shown by the 50% decrease in cluster of differentiation 11c (CD11c) and F4/80 mRNA levels as well as the ...
9
Glycemic improvement in diabetic db/db mice by overexpression of the human insulin regulatable glucose transporter (GLUT4)
... hGLUT4 db/db mice showed elevated plasma membrane-associated GLUT4 protein in the basal state, which markedly increased after an insulin/glucose ...nontransgenic db/db mice had ...
8
Polyphenolic extract of lotus root (edible rhizome of Nelumbo nucifera) alleviates hepatic steatosis in obese diabetic db/db mice
... male db/db mice (C57BLKS/J Iar-+Lepr db /+Lepr db ) were purchased from Japan SLC (Shizuoka, ...The mice were housed individually in plastic cages in a tem- perature-controlled ...
8
Establishment of an Inflamed Animal Model of Diabetic Nephropathy
... db/m mice and db/db mice, which were ob- tained from the Mode Animal Centre of Nanjing University (Nanjing, China), with a C57BL/KsJ ge- netic background, were studied using protocols ...
11
The vascular smooth muscle cell: A therapeutic target in type 2 diabetes?
... and diabetic db/db mice were shown to express elevated levels of RAGE, increased inflammatory gene expression and increased cell migration that were attenuated by a RAGE antibody ...Zucker ...
32
p38 MAPK inhibition reduces diabetes-induced impairment of wound healing
... in db/db ...the diabetic db/db mice (open circles) when compared to the nondiabetic db/+ mice (filled circles): (B) establishing the suitability of this ...in ...
10
Prevention of diabetic nephropathy in db/db mice with glycated albumin antagonists A novel treatment strategy
... of diabetic nephropathy. To test this hypothesis, diabetic db/db mice and their nondiabetic db/m littermates were treated with eight consecutive weekly injections of 150 ...
9
The loss of GLUT2 expression by glucose unresponsive beta cells of db/db mice is reversible and is induced by the diabetic environment
... of diabetic db/db mice was studied by a pancreas perfusion technique, and the levels of GLUT2 protein in pancreatic islets were assessed by immunofluorescence microscopy and protein blot ...
10
Targeting mitochondrial dynamics by regulating Mfn2 for therapeutic intervention in diabetic cardiomyopathy
... Obese diabetic (db/db) and lean control (db/+) mice were used in this ...Results: Diabetic hearts from 12-week-old db/db mice showed excessive mitochondrial ...
20
Effects of AGE Inhibition with Aminoguanidine in a Diabetic db/db Mouse Wound Model
... C57Bl/KsBom-db/db mice were ...The db/db strain is a well-recognized model for type 2 diabetes mellitus in which the diabetic state results from a deficient leptin receptor ...
8
Effect of echinacoside on kidney fibrosis by inhibition of TGF-β1/Smads signaling pathway in the db/db mice model of diabetic nephropathy
... in db/db mice, E-cadherin and α -SMA protein expression were detected by immunohistochemistry and Western blot (Figure 5A–C, F, and ...the db/m group, E-cadherin was significantly reduced in ...
14
Diet supplementation with green tea extract epigallocatechin gallate prevents progression to glucose intolerance in db/db mice
... consequence of lowered circulation fatty acid levels [17], as has been observed after EGCG and rosiglitazone feed- ing of db/db mice [18]. Reduced L-Cpt-1 expression would positively affect ...
10
<p>Artemether Regulates Metaflammation to Improve Glycolipid Metabolism in db/db Mice</p>
... to the suggestion that inhibition of in fl ammatory responses may provide a means to treat T2DM. 31 Of particular relevance to these fi ndings, our current results from liver protein chip analysis reveal that ATM can ...
11
An Inhibition Effect on Diabetic Cardiomyopathy Fibrosis of db/db Mice through Reduction of Myocardial Protein N-glycosylation by Crude 1-DNJ Extract from Homemade Bombyx Batryticatus mori.L
... Lectin blot image in Figure 7 indicated that α1,6-fucosylatioal level in DM, DMTH and DMTL group were all higher than the control group, however, the intergroup differences among these three groups were not so ...
31
Chronic stress aggravates glucose intolerance in leptin receptor-deficient (db/db) mice
... in db/db mice is not present in obese humans (Tartaglia et ...the db/db mouse has been used to study the leptin-dependent mechanism of obesity and T2D for over 40 ...in ...
10
Human adipose-derived mesenchymal stem cell-conditioned medium ameliorates polyneuropathy and foot ulceration in diabetic BKS db/db mice
... Despite the continuing and increasing incidence of DPN, nowadays, there is no specific treatment able to stop DPN progression and prevent the formation of foot ulcers (FU). Furthermore, the palliative drugs commonly ...
21