Dihydropteroate synthase
Interaction of sulfonamide and sulfone compounds with Toxoplasma gondii dihydropteroate synthase
... Toxoplasma gondii is a common protozoan disease that often causes life-threatening disease, particularly among patients with the acquired immunodeficiency syndrome. This study demonstrates that the dihydropteroate ...
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High Prevalence of Dihydropteroate Synthase Mutations in Pneumocystis jirovecii Isolated from Patients with Pneumocystis Pneumonia in South Africa
... encodes dihydropteroate synthase (DHPS), are associated with prior exposure to sulfa drugs, and their appearance suggests the emergence of variants with reduced sulfa ...
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Trends in drug resistance codons in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase genes in Kenyan parasites from 2008 to 2012
... SP resistance is conferred by mutations in Plasmodium falciparum dihydrofolate reductase ( Pfdhfr ) and P. falcip- arum dihydropteroate synthase ( Pfdhps ) genes [8,9], whose enzymes are target for ...
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Polymorphism of Plasmodium Falciparum Dihydrofolate Reductase and Dihydropteroate Synthase Genes among Pregnant Women with Falciparum Malaria in Banjar District, South Kalimantan Province, Indonesia
... 27. Mugittu K, Ndejembi M., Malisa A., Lemnge M, Premji Z, Mwita A, Nkya W, Kataraihya J, Abdulla S, Beck HP & Mshinda H (2004) Therapeutic Efficacy of Sulfadoxine- Pyrimethamine and Prevalence of Resistance Markers ...
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COMPARATIVE MODELING OF PLASMODIUM FALCIPARAM DIHYDROPTEROATE SYNTHASE 2 AND DOCKING STUDY AGAINST COMPOUNDS FROM ANTI-MALARIAL PLANT CARCIA PAPAYA AND SWERTIA CHIRATA
... The study revealed compounds reported from Carcia papaya and Swertia chirata has affinity to inhibit dihydropteroate synthase of Plasmodium falciparum. Therefore, further investigation in this aspect may be ...
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Ethyl Iso-allocholate from a Medicinal Rice Karungkavuni Inhibits Dihydropteroate Synthase in Escherichia coli: A Molecular Docking and Dynamics Study
... has become a major concern in recent decades. Pathogenic bacteria have the potential to transmit and acquire resistance to all available therapeutic agents. Development of drug resistance is a major cause that limits the ...
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Anti folate drug resistance in Africa: meta analysis of reported dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutant genotype frequencies in African Plasmodium falciparum parasite populations
... SP. Although a recent study did not find any rapid rise in the antifolate-resistant P. falciparum genotypes fol- lowing CTX treatment [40], continued surveillance is necessary to assess the long term trends. Chlorprogua- ...
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Mutational analysis of Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase genes in the interior division of Sabah, Malaysia
... Plasmodium falciparum , which causes the most severe form of malaria, is found mainly in the tropical and subtropical regions including Sabah, Malaysian Borneo. The spread of resistance to anti-malarial drugs poses an ...
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Low prevalence of dihydro folate reductase (dhfr) and dihydropteroate synthase (dhps) quadruple and quintuple mutant alleles associated with SP resistance in Plasmodium vivax isolates of West Bengal, India
... and dihydropteroate synthase (DHPS), two major proteins of the folate biosynthesis pathway of parasites [8, ...and dihydropteroate synthase (dhps) genes, throughout the globe ...
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Genetic mutations in Plasmodium falciparum and Plasmodium vivax dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) in Vanuatu and Solomon Islands prior to the introduction of artemisinin combination therapy
... SP is one of the most extensively used anti-malarials throughout the world; the SP drug combination primarily targets dihydrofolate reductase (DHFR) and dihydroptero- ate synthase (DHPS), critical enzymes in the ...
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Polymorphism in drug resistance genes dihydrofolate reductase and dihydropteroate synthase in Plasmodium falciparum in some states of India
... In an earlier study [18], the combined mutant genotypes were categorized for following types of clinical resistance; category "S/RI" with single or double mutation in combined genotype i[r] ...
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Molecular epidemiology of drug resistance markers of Plasmodium falciparum in Yunnan Province, China
... Many factors have contributed to the development and spread of drug resistance, including gene mutations and drug pressure [12]. Molecular surveillance is a new technique that has been implemented over the past decades ...
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Evaluation of dihydrofolate reductase and dihydropteroate synthetase genotypes that confer resistance to sulphadoxine pyrimethamine in Plasmodium falciparum in Haiti
... The in vitro and in vivo resistance of P. falciparum to PYR and SDX has been associated with single point mutations in the dihydrofolate reductase ( dhfr ) [10-12] and dihydropteroate synthase ( dhps ) ...
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Characterization of Streptococcus pneumoniae isolates from Austrian companion animals and horses
... CLSI: clinical and laboratory standards institute; DHFR: dihydrofolate reduc- tase; DHPS: dihydropteroate synthase; IPD: invasive pneumococcal disease; MALDI-TOF: matrix-assisted laser [r] ...
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Efficacy of artesunate amodiaquine for the treatment of acute uncomplicated falciparum malaria in southern Mauritania
... (dihydropteroate synthase (dhps) and dihydrofolate reductase (dhfr), re- spectively) in the same samples suggested low prevalence (<22%) of antifolate resistance ...
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Falciparum malaria molecular drug resistance in the Democratic Republic of Congo: a systematic review
... Five genes have been analysed in these studies: the Plasmodium falciparum chloroquine resistance transporter gene pfcrt, the dihydropteroate synthase gene pfdhps, the dihydrofolate reduc[r] ...
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Molecular surveillance of Plasmodium vivax dhfr and dhps mutations in isolates from Afghanistan
... Abstract Background: Analysis of dihydrofolate reductase dhfr and dihydropteroate synthase dhps mutations in Plasmodium vivax wild isolates has been considered to be a valuable molecular[r] ...
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Discovery of the fourth mobile sulfonamide resistance gene
... One dihydropteroate synthase gene, with less than 34% amino acid identity to the three known mobile sulfonamide resistance genes ( sul1–3 ), provided complete resistance when expressed in Escherichia coli ...
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Control and regulation of vitamin B12-dependent methionine synthase
... The general hypothetical explanations o f neurological disease are as follows: i) The methylmalonate hypothesis. Inactivation o f methylmalonyl CoA mutase, by lack o f cobalamin, causes a build up o f methylmalonyl CoA ...
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The Dominance of the Herbicide Resistance Cost in Several Arabidopsis thaliana Mutant Lines
... Resistance evolution depends upon the balance between advantage and disadvantage (cost) conferred in treated and untreated areas. By analyzing morphological characters and simple fitness components, the cost associated ...
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