direct reprogramming
Significant improvement of direct reprogramming efficacy of fibroblasts into progenitor endothelial cells by ETV2 and hypoxia
... induce direct reprogramming of fibroblasts into EPCs [40, 41] and of amniotic cells into EPCs ...the direct reprogramming of ETV2 transduction was low (about 1 %) ...improve ...
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Phenotype instability of hepatocyte-like cells produced by direct reprogramming of mesenchymal stromal cells
... Although the iHEPs generated herein displayed some degree of hepatocyte function, the gene expression pro- file differed from primary hepatocytes, showing a mixed expression of immature progenitors and mature hepato- ...
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The therapeutic potential of induced hepatocyte-like cells generated by direct reprogramming on hepatic fibrosis
... In this study, we used iHEPs by adopting two different direct reprogramming techniques. One is generated by retroviral introduction of specific transcription factors c-Myc and Klf-4 and the other is by ...
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Direct reprogramming of urine-derived cells with inducible MyoD for modeling human muscle disease
... robust reprogramming process is ...Alternatively, direct reprogramming with the transcription factor MyoD has been used to generate myotubes from cultured human ...
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Direct reprogramming of adult cells: avoiding the pluripotent state
... a direct reprogramming process that involves partial reprogramming toward the pluripotent ...delivering reprogramming factors to ...this reprogramming approach could be then directly ...
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Direct reprogramming of induced neural progenitors: a new promising strategy for AD treatment
... through direct reprogramming from somatic cells, which will set up a new concept for AD ...rectly reprogramming activated astrocytes in the patho- logical site of AD brain into region- or ...
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Direct reprogramming and biomaterials for controlling cell fate
... in direct reprogramming. Direct reprogramming occurs in con- junction with significant changes on epigenome includ- ing the histone modification ...on direct reprogramming from ...
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Direct reprogramming of fibroblasts into cardiomyocytes
... of reprogramming fibroblasts into cardiomyocytes ...years, direct reprogramming in the heart has made significant progress and has important implications in understanding the biology of heart ...cell ...
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Protocol: a method to study the direct reprogramming of lateral root primordia to fertile shoots
... Conversion of LRP to shoot must involve massive reprogramming in response to shoot inductive cues. Study of early cellular and molecular events regulating the reprogramming is essential to probe the ...
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Direct Reprogramming of Human Amniotic Fluid Stem Cells by OCT4 and Application in Repairing of Cerebral Ischemia Damage
... Amniotic fluid is known to contain multiple cell types derived from the developing fetus, some of which can be reprogrammed into iPSCs. For example, IPSCs have been generated from human amniotic fluid-derived cells using ...
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Direct in vivo cellular reprogramming involves transition through discrete, non pluripotent steps
... that direct cell type conversion involves a dedifferentiation step, even in the absence of cell ...that direct cell type conversion does not involve transition through a less differentiated identity (Zhou ...
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PubMedCentral-PMC5659840.pdf
... In this study, we performed a comparative analysis of the molecular characteristics of reprogrammed contractile CMs generated by direct reprogramming or differentiation of iPSCs from cardiac fibroblasts ...
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Potentials of cellular reprogramming as a novel strategy for neuroregeneration
... years, direct reprogramming has attracted enormous interest, yielding promising results in the conversion across multiple lineages to generate neurons, oligodendrocytes, cardiomyocytes, muscle cells, blood ...
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Heart regeneration for clinical application update 2016: from induced pluripotent stem cells to direct cardiac reprogramming
... of direct reprogramming to neonatal and adult human fi- broblasts in 2013 [29–31] (see Table ...of reprogramming factors generates epigenetically stable human iCMs, and that TGF-β signaling improves ...
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Cardiac-mimetic cell-culture system for direct cardiac reprogramming
... promote direct cardiac ...enables direct cell-cell contact interactions between cardiomyocytes and fibroblasts and paracrine factor interaction in coculture ...
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Direct neuronal reprogramming: learning from and for development
... and direct reprogramming has proven that cells from various lineages can be directly converted into cells of other lineages, even across germ layers – for example, fibroblasts or hepatic cells into neurons ...
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Effects of mechanical stimulation on the reprogramming of somatic cells into human-induced pluripotent stem cells
... in reprogramming can be obtained with mechanical stretching even though the infection effi- ciency in the stretched groups was lower than that in group CP ...
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Reprogramming of Small Noncoding RNA Populations in Peripheral Blood Reveals Host Biomarkers for Latent and Active Mycobacterium tuberculosis Infection
... observed reprogramming of sncRNA populations yielded small RNA biomarkers that can be used to identify difficult-to-diagnose TB cases regardless of level of lung injury (as seen on CXR images), bacterial load, or ...
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Financial report. EU budget 2008
... agricultural direct payments and market- related expenditure as well as that part of rural develop- ment expenditure originating from the EAGGF Guar- antee ...
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Induced Pluripotent Stem Cell Clones Reprogrammed via Recombinant Adeno-Associated Virus-Mediated Transduction Contain Integrated Vector Sequences
... of reprogramming factors into human foreskin fibroblasts resulted in the formation of colonies that ap- peared 10 to 12 days after ...the reprogramming factors (see ...
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