DNA Damage
A Synthetic Circuit For Control Of The Bacterial Dna Damage Response Without Dna Damage
... error-prone DNA repair in response to DNA ...a DNA damaging event, the damage sensor RecA activates LexA to undergo a self-cleavage reaction that results in LexA dissociation from SOS ...
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A Review of Probable Effects of Antioxidants on DNA Damage
... proteins, DNA and other against ...Species, DNA damage and fragmentation. The amount of damage to DNA and the mechanisms by which antioxidants affect in these studies were checked out ...
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Inflammation contributes to NKX3.1 loss and augments DNA damage but does not alter the DNA damage response via increased SIRT1 expression
... as DNA damage caused by TNFα-induced ROS directly induces cell cycle and/or apoptosis regula- tion by p53 ...dative damage and support cell ...
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Understanding the role of Claspin in DNA damage checkpoints
... of DNA damage and/or in the presence of errors in DNA replication (Abraham 2001; Nyberg et ...the DNA damage has been encountered until the damage is repaired (Sancar et ...the ...
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A SIGNIFICANT METHOD TO EXPLORE DNA DAMAGE IN LYMPHOCYTES
... The DNA is a stable and well protected molecule composed of two chains of that coil around each other to form a double helix for carrying genetic instructions used in growth, development, functioning and ...
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The immunological consequences of radiation-induced DNA damage.
... specific DNA damage response inhibitors (DDRi) to radiotherapy may increase cytosolic DNA and thereby augment the interferon responses described ...
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Persistent DNA Damage Foci and DNA Replication with a Broken Chromosome in the African Trypanosome
... ribosomal DNA (rDNA) locus (40) ...to DNA damage in a second pol-I-associated subnuclear compartment, the ...stringent DNA damage checkpoint in ...
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Role and Regulation of CIEBPa in Response to DNA Damage
... to DNA damage response To determine whether GSK3β has a role in C/EBPα induction in response to DNA damage, we treated BALB/MK2 keratinocytes with the GSK3β specific pharmacological ...
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DNA damage induces nuclear translocation of parkin
... in DNA damage repair, I examined whether parkin associated with damaged ...when DNA was damaged by UV irradiation ...with damage DNA also occurred in human brain tissues with endogenous ...
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Bile-Induced DNA Damage in Salmonella enterica
... 1985 Viability of Escherichia coli K-12 DNA adenine methylase ment of its role in virulence. J. Bacteriol. 179: 1857–1866. (dam) mutants requires increased expression of specific genes Sutton, M. D., B. T. Smith, ...
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Oxidant induced DNA damage of target cells
... oxidant damage of DNA in whole ...induced DNA strand breaks in various target ...induced DNA breakage of target cells in proportion to the amount of H2O2 ...These DNA strand breaks were ...
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Roles of Ubiquitination and SUMOylation in DNA Damage Response
... damaged DNA is repaired correctly and timely is key to maintain genome integrity, otherwise unrepaired DNA lesions may cause cells to die or accumulated DNA alternations may induce tumorigenesis ...
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DNA-PK suppresses a p53 independent apoptotic response to DNA damage
... to DNA damage. After DNA damage, p53 is rapidly phosphorylated by the Atm and Atr protein kinases, leading to its stabilization, induction of its transcriptional targets, and cell cycle arrest ...
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Sperm DNA damage and its role in IVF and ICSI
... sperm DNA damage on reproductive outcomes during IVF and ICSI are currently being hampered by our poor under- standing of sperm DNA damage, including the effects of measured sperm DNA ...
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DNA damage repair in ovarian cancer: unlocking the heterogeneity
... A defective DNA-damage response (DDR) is a defining hallmark of high grade serous ovarian cancer (HGSOC). Indeed, current evidence indicates that all HGSOCs harbour a defect in at least one major DDR ...
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DNA damage protection: an excellent application of bioactive compounds
... death, DNA damage and early aging problems (Desouky et ...of damage may vary from organism to organisms depending on the type selected for experimental ...
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ATP-dependent chromatin remodeling in the DNA-damage response
... Different members of the CHD family of chromatin remodelers are involved in regulating DSB repair in chromatin. It has been shown that CHD3 is dispersed from DSBs in heterochromatin via a mechanism invol- ving KAP-1 ...
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Measurement of DNA damage by terminal deoxynucleotidyl transferase reaction
... method, DNA damage in cells cultured in medium without serum was evaluated (Figure ...induced DNA damage in a time-dependent ...evaluate DNA damage status caused by apoptosis in ...
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PIG3 Functions in DNA Damage Response through Regulating DNA-PKcs Homeostasis
... The DNA damage response is a comprehensive signaling process including damage sensing, media- tors’ activation, cell cycle arrest and DNA ...in DNA damage response induced by UV ...
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Damaged-DNA Binding Protein-2 Drives Apoptosis Following DNA Damage
... following DNA damage is important, as it inhibits the apoptotic pathway to allow a window of opportunity for cells to repair the ...after DNA damage can be viewed as a survival ...after ...
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