DNA mismatch
PMS2 gene mutation results in DNA mismatch repair system failure in a case of adult granulosa cell tumor
... induces DNA mismatch repair system failure. Our hypothesis is that DNA mismatch repair system failure induces FOXL2 402C > G mutation, leading to granulosa cell tumor development ...The ...
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Dynamics of DNA Mismatch Repair Initiation Complexes Revealed by Single Molecule Fluorescence.
... the DNA mismatch repair protein MutS that control its roles in MMR ...The DNA binding domain I of MutS undergoes substantial conformational changes during mismatch recognition and signaling ...
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Saturation of DNA Mismatch Repair and Error Catastrophe by a Base Analogue in Escherichia coli
... coli DNA mismatch-repair system can protect cells against this mutagenic ...in mismatch-repair-defective mutH, mutL, and mutS strains than in a wild-type ...the mismatch-repair system can ...
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Functional role of DNA mismatch repair gene PMS2 in prostate cancer cells
... DNA mismatch repair (MMR) enzymes act as proofreading complexes that maintains genomic integrity and MMR-deficient cells show an increased mutation ...
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Maternal Effect for DNA Mismatch Repair in the Mouse
... DNA mismatch repair (DMR) functions to maintain genome stability. Prokaryotic and eukaryotic cells deficient in DMR show a microsatellite instability (MSI) phenotype characterized by repeat length alter- ...
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Dual daughter strand incision is processive and increases the efficiency of DNA mismatch repair
... DNA mismatch repair (MMR) is crucial for the mainte- nance of genomic ...for mismatch recognition and endonucleolytic incision of the newly-synthesized DNA strand ...quently, DNA ...
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The Role of DNA Mismatch Repair and Recombination in the Processing of DNA Alkylating Damage in Living Yeast Cells
... the DNA alkylating agent (less than 1 per 100 cells, Figure 3(a) top left panel) and is increased at least 15-fold after treatment (Figure 3(a) top right panel and Figure ...for DNA damage in general ...
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DNA mismatch repair gene MSH6 implicated in determining age at natural menopause
... which DNA repair influences timing of menopause is yet to be determined, but it is conceivable that damage to DNA of meiotic cells, if not repaired effectively, would result in the activation of apoptotic ...
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Escherichia coli mutator mutD5 is defective in the mutHLS pathway of DNA mismatch repair.
... Competent cells derived from the mutD5 strain are severely affected in their ability to perform mismatch repair, yielding a percentage of mixed bursts close to that of the mu[r] ...
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Evolutionary consequences of DNA mismatch inhibited repair opportunity.
... T h e natural selection attributable to the interaction between mismatch in- hibited repair opportunities associated with nucleotide sequence heterozygosity and increased le[r] ...
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Thyroid cancer in a patient with a germline MSH2 mutation. Case report and review of the Lynch syndrome expanding tumour spectrum
... Rüschoff J, Fishel R, Lindor NM, Burgart LJ, Hamelin R, Hamilton SR, Hiatt RA, Jass J, Lindblom A, Lynch HT, Peltomaki P, Ramsey SD, Rodriguez-Bigas MA, Vasen HF, Hawk ET, Barrett JC, Freedman AN, Srivastava S. Revised ...
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Molecular pathogenesis in granulosa cell tumor is not only due to somatic FOXL2 mutation
... addition, DNA replication error, on analysis of the lengths of CAG repeats in androgen receptor gene, revealed defective DNA mismatch repair system in the granulosa cell ...by DNA ...
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Genetic variants within the hTERT gene and the risk of colorectal cancer in Lynch syndrome
... Lynch syndrome, formerly known as hereditary non-polyposis colorectal cancer, is an autosomal dominant disorder caused by germline mutations in one of the DNA mismatch repair (MMR) genes MLH1, MSH2, MSH6, ...
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Requirement of Mismatch Repair Genes MSH2 and MSH3 in the RAD1-RAD10 Pathway of Mitotic Recombination in Saccharomyces cerevisiae
... The MSH2 and MSH3 genes participate in DNA mismatch repair; null mutations in these genes result in elevated rates of spontaneous mutations and in an increase in the [r] ...
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TP53 Mutational Status Is a Potential Marker for Risk Stratification in Wilms Tumour with Diffuse Anaplasia
... the DNA repair pathway found by this study have not been evaluated in ...the DNA mismatch repair system mainly in favourable histology WT based on the pattern of protein expression of MLH1, PMS2, ...
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Electrochemical sensors based on DNA mediated charge transport chemistry
... with DNA double helices and used to monitor the electrochemistry of bound redox active ...a DNA-mediated reaction, provides an indicator of base stacking within the surface-bound ...stacked DNA is ...
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A Test of the Double-Strand Break Repair Model for Meiotic Recombination in Saccharomyces cerevisiae
... The DSBR model, as modified to retain fully the 3‘- ended strands (absent mismatch correction), predicts that hDNA will be present on both DNA molecules that emerge from a[r] ...
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Mechanisms of directed mutation.
... The absence of two DNA repair pathways- methyl-directed mismatch repair and alkylation repair-also did not result in an accumulation of Lac+ mutants in the absence of lactose,[r] ...
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Measuring DNA hybridization using fluorescent DNA-stabilized silver clusters to investigate mismatch effects on therapeutic oligonucleotides
... of DNA as a nanoscale posi- tioning tool, and the optical properties of noble metal nanoparticles, has led to the construction of a wide array of signaling tools for use in biology and medicine [16, ...fluorescent ...
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Mismatch Repair of DNA Replication Errors Contributes to Microevolution in the Pathogenic Fungus Cryptococcus neoformans
... the mismatch repair [MMR] pathway predicted to be required to repair damage to single bases arising from errors in DNA replication) resulted in increased proliferation in a lung assay of cryptococcosis ...
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