Dose-Dense
Survival benefit of pure dose dense chemotherapy in breast cancer: a meta analysis of randomized controlled trials
... pure dose-dense chemotherapy leads to prolonged DFS and highlights a significant OS benefit in node-positive ...with dose-dense chemotherapy, there was no sign of interaction be- tween ...
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Switching from standard to dose-dense chemotherapy in front-line treatment of advanced ovarian cancer: a retrospective study of feasibility and efficacy
... to dose-dense chemotherapy was 70% (Gynecological Cancer Intergroup ...the dose-dense group, 24 patients had tumour progression and 16 died; the corresponding numbers in the control group were ...
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Dose Dense Regimen of Cisplatin and Infusional Fluorouracil in Advanced Gastric Cancer—A Single Institution Experience
... the dose-dense strategy in other tumors, we decided to adopt this approach in this ...A dose-dense FUP regimen, given every three in- stead of four weeks, has already been used in localized ...
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Accelerated BEP : a phase I trial of dose dense BEP for intermediate and poor prognosis metastatic germ cell tumour
... of dose-dense versus conventionally scheduled and sequential (2003) versus concurrent combination chemotherapy as postoperative adjuvant treatment of node-positive primary breast cancer: first report of ...
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HER2 and TOP2A in high risk early breast cancer patients treated with adjuvant epirubicin based dose dense sequential chemotherapy
... Based upon this information we performed a compre- hensive evaluation of HER2 and TOP2A parameters in tumors from patients that had participated in the Helle- nic Cooperative Oncology Group (HeCOG) phase III trial ...
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Dose dense adjuvant chemotherapy for primary breast cancer
... the dose dense ...(more dose dense) plan was associated with significantly improved DFS and ...increased dose intensity of doxorubicin could account for the superiority of the latter ...
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Characterizing and quantifying the effects of breast cancer therapy using mathematical modeling
... Abstract We designed a mathematical model to describe and quantify the mechanisms and dynamics of tumor growth, cell-kill and resistance as they affect durations of benefit after cancer treatment. Our aim was to explore ...
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Survival is associated with complete response on MRI after neoadjuvant chemotherapy in ER positive HER2 negative breast cancer
... Abbreviations AC, doxorubicin and cyclophosphamide; AD; doxorubcin and docetaxel; CR, complete remission; ddAC, dose-dense cyclophosphamide and doxorubicin; ER, estrogen receptor; HER2, [r] ...
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Characterizing and quantifying the effects of breast cancer therapy using mathematical modeling
... and genetic understanding grows in this and other cancers, identification of patients with different outcomes will be increasingly possible. The model demonstrates that it is possible to determine these differences, and ...
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Next generation sequencing of triple negative breast cancer to find predictors for chemotherapy response
... Abbreviations bp: base pairs; CNA: copy number alteration; COSMIC: Catalogue of Somatic Mutations in Cancer; ddAC: dose dense cyclophosphamide, doxorubicin; DSB: double strand break; EGF[r] ...
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nab Paclitaxel dose and schedule in breast cancer
... of dose-dense nab- paclitaxel regimens in early BC (Table ...with dose-dense AC plus bevacizumab, followed by four cycles of dose- dense nab-paclitaxel 260 mg/m 2 plus ...
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Treatment of Newly Diagnosed and Relapsed Hodgkin Lymphoma in Children
... The COG study P9425 was based on early response to limit cumulative chemotherapy in advanced-stage HL patients and to enhance early response through a dose- dense chemotherapy regimen (adriamycin, ...
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Temozolomide in malignant glioma
... In a recently published randomized phase II study irradiation plus concomitant temozolomide followed by either dose-dense or metronomic temozolomide was compared in newly diagnosed GBM patients. Toxicity ...
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Current Possible Drug Therapies for Ovarian Cancer
... a dose of AUC 5 - 6. This is repeated every 3 weeks for six cycles. Dose dense thera- py is strategy to enhance antitumor activity to focus on rapid regrowth of tumor between treatment ...the ...
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PubMedCentral-PMC5065725.pdf
... In our study of 31 patients only one had a complete response. According to the primary objective of the study, our data do not justify continuing to evaluate single agent paclitaxel administered every three weeks for ...
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nab-Paclitaxel for the treatment of breast cancer: an update across treatment settings
... ddAC dose-dense AC, DLT dose-limiting toxicity, EC epirubicin + cyclophosphamide, FEC fluorouracil, epirubicin, and cyclophosphamide, gem gemcitabine, HER2 human epidermal growth factor receptor 2, ...
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Commute Times in Dense Graphs
... Although anchor graphs provide meaningful commute distances with low- complexity spectral representations, some authors have proposed more efficient methods where anchor graphs are bypassed for computing these distances. ...
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Caching or No Caching in Dense HetNets
... tier 2), the cost is shown to monotonically increase despite the fact that the backhaul-usage probability, , becomes considerably smaller (Fig. (2)-a). In this case, although the usage of backhaul is reduced with an ...
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Wave breaking in dense plumes
... This raises an important possibility. A pulsed source produces waves that travel down the plume, and simple analytical investigation of a reduced system suggests that these waves should break within 50 km of the source ...
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Nucleosynthesis in Hot and Dense Media
... and dense media to accurately calculate their contributions to nuc- ...and dense media at this scale, provided the neutrinos have nonzero mass due to extensions in the standard model, we would have to ...
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