DOX, doxorubicin
Synthesis and Characterization of Nanodiamond-Doxorubicin (Dox) Conjugate for Effective Delivery against MCF-7 Cell Lines
... The in-vitro drug release characteristics of the prepared ND- DOX conjugate were performed by modified dissolution technique. The prepared conjugate were placed separately in dialysis bag (Himedia Lab Limited, ...
6
Codelivery of curcumin and doxorubicin by MPEG-PCL results in improved efficacy of systemically administered chemotherapy in mice with lung cancer
... and doxorubicin on an LL/2 tumor cell ...to doxorubicin, 1:1) was more effective than curcumin and doxorubicin alone at concentrations of ...9.34%, doxorubicin-induced apoptosis was ...the ...
11
Preparation of folic acid-conjugated, doxorubicin-loaded, magnetic bovine serum albumin nanospheres and their antitumor effects in vitro and in vivo
... of doxorubicin from the samples was determined by ultraviolet spectrophotometry, and the cumu- lative release at various time points in three pH solutions (pH ...cells, doxorubicin would release from ...the ...
13
<p>Doxorubicin Delivered Using Nanoparticles Camouflaged with Mesenchymal Stem Cell Membranes to Treat Colon Cancer</p>
... the DOX-SPIO@MSCs group, implying that DOX-SPIO @MSCs do not exhibit obvious systematic toxicity (Figure ...the DOX-SPIO@MSCs-treated group revealed pro- nounced morphological characteristics ...
12
Development of Magnetic Nanocarriers based on Thermosensitive Liposomes and their Visualization using Magnetic Particle Imaging
... The use of nanoparticles in diagnosis and therapy for cancer is progressively growing, and may be one of the most important developments in drug delivery systems. Liposomes are highly biocompatible and biodegradable ...
11
A gold nanoshell with a silica inner shell synthesized using liposome templates for doxorubicin loading and near-infrared photothermal therapy
... the DOX-loaded liposome/SiO 2 /Au. This suggests that the toxicity of the DOX-loaded liposome/SiO 2 /Au was stronger than that of the liposome/SiO 2 /Au without ...with DOX with or with- out NIR ...
7
Synthesis of Europium-doped Fluorapatite Nanorods and Their Multifunctional Biomedical Applications
... The drug loading and release system using Eu-FA nanorods as the carrier was prepared using an absorption method. 2 mg of the Eu-FA sample were added to 400 μL of a PBS solution at room temperature. Doxorubicin ...
6
Tumor Spheroids as an In Vitro Model for Determining the Therapeutic Response to Proton Beam Radiotherapy and Thermally Sensitive Nanocarriers
... Multicellular Tumor Spheroids (MCTS) strongly resemble tumor tissues, which makes them useful tools for radiation biology studies and screening of various chemotherapeutics. The goal of this pilot study was to use MCTS ...
5
Empagliflozin prevents doxorubicin-induced myocardial dysfunction
... the DOX group compared to ...of doxorubicin myocardial ...with doxorubicin, in some morphological variants (lower left and mid panels and upper mid ...the DOX group (lower right ...in ...
11
Self-assembled poly(ε-caprolactone)-<em>g</em>-chondroitin sulfate copolymers as an intracellular doxorubicin delivery carrier against lung cancer cells
... were taken up by the RES such as the liver, and the fluorescence intensity in the NCI-H358 tumor was higher than that in CRL-5802. This finding was consistent with the result in the cellular uptake study conducted using ...
15
Valproic Acid Induces Endocytosis-Mediated Doxorubicin Internalization and Shows Synergistic Anti-Proliferation Effects in Hepatocellular Carcinoma Cells
... and DOX exhibited a dramatic synergistic effect over VPA or DOX monotherapy at a clinically relevant ...available DOX can be imported to the cell by diffusion methods [24], while DOX ...
15
Doxorubicin-conjugated bacteriophages carrying anti-MHC class I chain-related A for targeted cancer therapy in vitro
... conjugation 2 hours before Doxorubicin (Dox)-carrying phage- displaying anti-MICA (Dox-phage) treatment. The amount of doxorubicin on phage particles are shown in Table 1. All testing samples ...
13
Targeting therapy of hepatocellular carcinoma with doxorubicin prodrug PDOX increases anti metastatic effect and reduces toxicity: a preclinical study
... and DOX were ...and DOX were ...free DOX toward metastasis is remarkable and to our knowledge unprecedented, for usually me- tastases are more resistant than primaries to chemo- ...over DOX is ...
12
A Multifunctional Theranostic Nanoagent for Dual-Mode Image-Guided HIFU/Chemo- Synergistic Cancer Therapy
... encapsulating doxorubicin (DOX) and perfluorohexane ...of DOX thereby enhancing chemotherapeutic efficacy and avoiding systemic side effects of the ...
14
Cytotoxicity of graphene oxide and graphene oxide loaded with doxorubicin on human multiple myeloma cells
... GO-treated, DOX-treated, and GO/DOX-treated cells was monitored by optical microscope at 24 ...2B). DOX-treated cells exhibited typi- cal apoptotic features, such as membrane blebbing and cell ...
9
In Vitro Studies of NIPAAM MAA VP Copolymer Coated Magnetic Nanoparticles for Controlled Anticancer Drug Release*
... cipitation of Fe salts in the ratio of 1:2 under alkaline and inert condition. Thermosensitive crosslinked P (NI- PAAM-MAA-VP) copolymers were characterized by FT-IR and H-NMR. The pH and thermosensitive copolymer was ...
8
Preparation, characterization and application of star-shaped PCL/PEG micelles for the delivery of doxorubicin in the treatment of colon cancer
... of Dox/SSMPEG-PCL micelles was studied using a dialysis ...8E, Dox was released from Dox/SSMPEG-PCL micelles over an extended ...Meanwhile, Dox release from Dox/SSMPEG-PCL was faster at ...
12
Cytotoxicity Effect of the Combination of Doxorubicin and Pravastatin Loaded in Lipid Nanoemulsion on MCF-7 Breast Cancer Cells and HFS Human Foreskin Cells
... like DOX on the RBCs as they may cause anemia ...formulations, DOX-W has the largest effect on the RBCs by revealing the maximum percentage of hemolysis activity of ...with DOX in water has reduced ...
9
Enhanced antitumor efficacy of doxorubicin-encapsulated halloysite nanotubes
... the DOX group, the use of drugs inhibited tumor growth and reduced consumption of the body, but the side effects of DOX led to body weight ...the DOX group ...of DOX. This result further shows ...
12
Triphenyl Phosphine Functionalized Chitosan Nanoparticles Enhanced Antitumor Efficiency Through Targeted Delivery of Doxorubicin to Mitochondria
... free doxorubicin (Dox), Dox-loaded TPP-NPs were specifically distributed in mitochondria of tumor cells and interfered with the function of mitochondria, thus resulted in the higher cytotoxicity and ...
9