Drug Allergy, Drug Hypersensitivity
Drug allergy
... Drug allergy encompasses a spectrum of immunologically‑mediated hypersensitivity reactions with varying mechanisms and clinical ...adverse drug reaction not only affects patient quality of ...
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7th drug hypersensitivity meeting: part one
... Report: A 55 year old man, a smoker with type II Diabetes, was admit- ted to our hospital for myocardial infarction (MI) after taking two pills of diclofenac 75 mg for left leg pain. He complained of immediate gen- ...
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A Practical Approach to Demystifying Drug Allergy in the Intensive Care Unit A Review Article
... Drug hypersensitivity reaction (DHR) is defined as an immunologically me- diated response to a pharmacology agent. Some reactions require prior sensi- tization and some do not. The interactions between ...
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Update on the Management of Nonsteroidal Anti Inflammatory Drug Hypersensitivity
... delayed hypersensitivity reac- tions (NIDHR), culprit NSAID avoidance is ...Clear drug labeling, use of drug allergy passport, and comprehensive pa- tient-education ensure that both healthcare ...
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Predicting Drug Hypersensitivity Reactions: Mechanistic and Clinical Implications
... of allergy to different drugs,[37] files of 923 patients with possible hypersensitivity reactions to drugs were ...where drug allergies were “definite,” “probable,” “less probable” or ...of ...
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An EAACI task force report: recognising the potential of the primary care physician in the diagnosis and management of drug hypersensitivity
... post-graduate allergy educational programs and training should be ...about drug hypersensitiv- ity testing are not adequately addressed, and need fur- ther ...with drug allergy in order to ...
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Approach to the diagnosis of drug hypersensitivity reactions: similarities and differences between Europe and North America
... multiple drug allergy syndrome whose medical care is impacted by their challenging allergy ...U.S. drug allergy specialists desensitize in most cases if there is a highly suspected ...
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7th Drug hypersensitivity meeting: part two
... immune-mediated hypersensitivity reactions (drug ...non-immediate hypersensitivity reactions is not well ...of allergy to BLAs and to investigate the their different underlying ...(85 ...
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Pathophysiologic Mechanisms of Immune-mediated Drug Hypersensitivity Reactions to Sulfonamides
... such as bacterial or viral infection. However, other studies showed that danger can also be received in the absence of foreign substances from virally infected cells or dead cells (Gallucci et al., 1999; Shi et al., ...
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Comprehensive allergy work-up is mandatory in cystic fibrosis patients who report a history suggestive of drug allergy to beta-lactam antibiotics
... culprit drug (the 17 remaining negative skin tests patients) or with an alternative when the culprit one was skin test ...administered drug: 2,816 grams), while the second one presented a periorbital ...
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Evaluation of drug information resources for drug-ethanol and drug-tobacco interactions
... 4]. Drug interactions are a major contributor to adverse drug events, which occur in about 6% of hospitalized patients [5] and are responsible for about ...adverse drug reactions and 42% and 62% of ...
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Heart Rate Variability Signal Precedes Clinical Symptoms in Hypersensitivity Reactions during Drug Provocation Tests
... The design of algorithms for automated analysis of ECG data has been an area of research for more than 40 Years. QRS detection algorithms are needed to analyze ECG recordings generated in telehealth environments. They ...
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ROLE OF COMPUTER AIDED DRUG DESIGN IN DRUG DEVELOPMENT AND DRUG DISCOVERY
... in drug discovery in past few years demonstrated the utility in the process of drug ...of drug - receptor interaction on the molecular basis and access the medicinal chemistry in designing of new ...
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Drug transport and drug-drug interactions at the blood-brain barrier
... SLCO1B1 and SLCO1B3 are not expressed at the BBB (Roth et al. 2011). Instead, SLCO1A2 (OATP1A2) and SLCO2B1 (OATP2B1) may be of particular importance for the uptake of drugs into the CNS. Both transporters have been ...
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Drug-drug interactions with raltegravir
... a drug-drug interaction as often doses and food intake are not observed, there is no intrapa- tient comparison, and other agents may be co-admin- ...
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Adverse drug reaction classification by health professionals: appropriate discrimination between allergy and intolerance?
... Overriding of prescribing alerts has been shown to be common, presumably at least in part because mild or trivial reactions may also generate alerts [17, 18]. There is evidence that a number of strategies including ...
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Index Terms - Adverse drug reactions, Drug interactions, Drug-
... patient's drug treatment that actually or potentially interferes with the achievement of an optimal ...adverse drug reactions (ADRs), unnecessary drug therapy, untreated conditions, Wrong ...
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Data-driven prediction of adverse drug reactions induced by drug-drug interactions
... revealed drug classes highly likely to be involved in DDI-induced ADRs, such as those targeting the cardiovascular or musculo-skeletal ...identified drug combinations supported by the literature but not yet ...
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Drug resistance genomics of the antimalarial drug artemisinin
... The propeller-domain mutations in pf3kelch13 were only associated with resistance, although strongly, and were not shown to be causal. A genome-modification method, the CRISPR-Cas9 system, which was established for gen- ...
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Drug–drug Interactions in Hospitalized Cardiac Patients
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