Drug discovery and development and research
Vertebrate melanophores as potential model for drug discovery and development: A review
... of research and studies done so far together with the research still in the pipeline indicates that the agonists and antagonists directed towards specific adrenergic, histaminergic, cholinergic and ...
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Role of G-Protein Coupled Receptors in Cancer Research and Drug Discovery
... especially development of cancers and metastasis, have been made them significant for drug discovery programs and hiring them as therapeutic drug ...in drug discovery and recent ...
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CURRENT TRENDS IN DRUG DISCOVERY: TARGET IDENTIFICATION TO CLINICAL DEVELOPMENT OF THE DRUG
... the drug discovery process has been revolutionized with the involvement of some newer ...based drug design is more advantageous, time consuming and ...new drug candidate called analogues which ...
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Drug discovery and development for neglected diseases: the DND<em>i</em> model
... of drug discovery have been developed to overcome the lack of modern and effective drugs for neglected diseases such as human African trypanosomiasis (HAT; sleeping sickness), leishmaniasis, and Chagas ...
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Linked open drug data for pharmaceutical research and development
... widespread in individual companies, it is on the agenda of several large-scale cross-pharma projects. An Eur- opean project, the Open Pharmacological Space (OPS) Open PHACTS (Pharmacological Concept Triple Store) project ...
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Machine Learning in Drug Discovery and Drug Design
... the drug development process, 50% of the failures[133] in late development stages are due to an unfavorable ADMET profile (Absorption, Distribution, Metabolism, Excretion & ...of research ...
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Inaugural Charles River World Congress on Animal Models in Drug Discovery and Development
... our research is to develop contrasting animal model systems to systematically translate the clinical observation that variation in exer- cise capacity is a strong indicator of health and underlies our risk for ...
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Interferon, viruses and drug discovery
... To the best of our knowledge, there are no known chemical antagonists of MAVS, and only one chemical modulator of RIG-I activity. Bufalin, an FDA approved cardiac glycoside, appears to inhibit the ATPase activity of ...
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View of Anti HIV Prolific Drug Discovery | Journal of Current Medical Research and Opinion
... property of p17 to increase production of proinflammatory cytokines could be a mechanism exploited by the virus to create a more suitable environment for HIV-1 infection and replication. Our data show that p17 exerts its ...
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Chemical Genomics: A Systematic Approach in Biological Research and Drug Discovery
... ligand discovery through natural-product screening has spearheaded therapeutics development and biological discovery for many years (Bull et ...the drug discovery ...
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Innovation in neglected tropical disease drug discovery and development
... product development partnership (PDP) model now plays a crucial role in drug innovation, which usually involves research institutions, pharmaceutical companies, government agencies and international ...
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Development and Interpretation of Machine Learning Models for Drug Discovery
... This thesis is divided into three main parts. Part I describes the development of two methods for specialized use cases in LBVS. Herein, chapter 1 uses structural SVMs to model compound profiling experiments, and ...
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Drug discovery in jeopardy
... of drug companies. Reduced pro- ductivity in the drug industry is caused mainly by corporate policies that discourage ...of research from scientists to marketers, the need for fast sales growth, and ...
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Technology Trends in Drug Discovery and Development: Implications for the Development of the Pharmaceutical Industry in Australia
... Many of the Australian subsidiaries of the multinational pharmaceutical companies have been here for a long time and have well established distribution and marketing operations. Some such as Merck, Sharpe & Dohme and ...
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The Drug Discovery Development for Treatment of Tuberculosis
... Our research group has explored the chemistry of various heterocycles and their sugar hybrids and receieved overwhelming response in this direction, though many obstacle The present state of knowledge provided ...
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CLINICAL PHARMACOKINETICS CONCEPTS IN THE DRUG DISCOVERY AND DEVELOPMENT PROCESS OF PHYTOMEDICINES IN SOME DEVELOPING COUNTRIES
... and drug administration (FDA) have set up regulatory guidelines for the production of clinical research for investigational drugs to be regulatory ...the drug development ...for drug ...
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The Stages of Drug Discovery and Development Process
... Drug discovery is a process which aims at identifying a compound therapeutically useful in curing and treating ...of drug development earlier to clinical trials. New drug ...
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Continuous microflow photochemistry and its application in pharmaceutical drug discovery, development and production
... in research laborato ries for small scale synthesis typically ≤ 100mL Merry go round accessories with multiple irradiation tubes are available for both reactor types and enable limited paral lel synthesis ...
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A REVIEW ON THE ROLE OF PHARMACOGENOMICS IN DRUG DISCOVERY AND DEVELOPMENT
... in drug response. It deals with the effect of genetic variation on drug response in patient by correlating the gene expression with the pharmacokinetic parameter ...the research to increase the ...
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REVIEW ON RECENT ANTIDIABETIC DRUG TARGETED PROTEINS FOR RATIONAL DRUG DISCOVERY AND DEVELOPMENT
... pharmaceutical research community because it was shown that the inhibition of its catalytic activity led to the retardation of glucose absorption and the decrease in postprandial blood glucose ...
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