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drug disposition

The role of drug disposition genes for variability in the pharmacokinetics of antiretroviral drugs

The role of drug disposition genes for variability in the pharmacokinetics of antiretroviral drugs

... Both influx and efflux transporters are important in determining oral drug disposition by controlling absorption and bioavailability. See Figure 1.3 and 1.4 for their localization in enterocytes and ...

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Yale School of Public Health Symposium on tissue imaging mass spectrometry : illuminating phenotypic heterogeneity and drug disposition at the molecular level

Yale School of Public Health Symposium on tissue imaging mass spectrometry : illuminating phenotypic heterogeneity and drug disposition at the molecular level

... all drug discovery and development stages [29, ...of drug analytes in tissue distributions with histology images, thereby integrating chemical structures with tissue ...of drug disposition, ...

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Pathophysiological changes that affect drug disposition in protein-energy malnourished children

Pathophysiological changes that affect drug disposition in protein-energy malnourished children

... classification is however more useful in epidemiological studies of PEM in a large population of children [3,10]. Other methods of PEM classification have been used in clinical studies [11]. Most of the previous studies ...

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 BIOPHARMACEUTICS DRUG DISPOSITION CLASSIFICATION SYSTEM: AN EXTENSION OF BIOPHARMACEUTICS CLASSIFICATION SYSTEM

 BIOPHARMACEUTICS DRUG DISPOSITION CLASSIFICATION SYSTEM: AN EXTENSION OF BIOPHARMACEUTICS CLASSIFICATION SYSTEM

... of drug products from measurements of permeability and ...overall drug disposition, including routes of drug elimination and the effects of efflux and absorptive transporters on oral ...

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New Equilibrium Models of Drug-Receptor Interactions Derived from Target-Mediated Drug Disposition

New Equilibrium Models of Drug-Receptor Interactions Derived from Target-Mediated Drug Disposition

... in drug-related discovery projects and mechanistic ...pharmacodynamic drug-drug interactions are ...of drug-induced target suppression is very much governed by target turnover properties ...

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The use of MALDI MS for imaging drug disposition in respiratory disease models

The use of MALDI MS for imaging drug disposition in respiratory disease models

... a drug onto control tissue sections to generate a calibration curve, this is then used to determine the amount of the analyte of interest in different areas of the dosed tissue section as recently described by ...

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Development of human membrane transporters: drug disposition and pharmacogenetics

Development of human membrane transporters: drug disposition and pharmacogenetics

... the drug is now rarely used in pediatric clinical care, this latter promise necessitates a full under- standing of its disposition across the pediatric age range, as part of studies to confirm this new ...

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The Circadian Clock Gene Bmal1 Controls Intestinal Exporter MRP2 and Drug Disposition

The Circadian Clock Gene Bmal1 Controls Intestinal Exporter MRP2 and Drug Disposition

... oral drug detoxification (but the first barrier to oral drug ...converts drug molecules into inactive metabolites (note that the pro-drug is an exception), whereas the latter blocks intestinal ...

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Nanosuspension delivery of paclitaxel to xenograft mice can alter drug disposition and anti tumor activity

Nanosuspension delivery of paclitaxel to xenograft mice can alter drug disposition and anti tumor activity

... yet drug was not really eliminated from the body, but rather trapped in the ...of drug in tissue may be that the nanoparticles in the nanosuspension may be dis- solving slower than anticipated in vivo ...

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Role of hepatic transport proteins in drug disposition and drug-induced liver injury

Role of hepatic transport proteins in drug disposition and drug-induced liver injury

... the disposition of some phase II conjugates might be anticipated, considering the important role of transport proteins in the biliary and basolateral excretion of phase II ...hepatobiliary disposition may ...

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Species difference in paclitaxel disposition correlated with poor pharmacological efficacy translation from mice to humans

Species difference in paclitaxel disposition correlated with poor pharmacological efficacy translation from mice to humans

... circulating drug decline is governed by distribution rather than elimination (Figure ...higher drug accumulation in the peripheral compartment. In mice, however, drug elimina- tion is the main factor ...

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Applicability of the Principles of Developmental Pharmacology to the Study of Environmental Toxicants

Applicability of the Principles of Developmental Pharmacology to the Study of Environmental Toxicants

... of drug disposition, including absorption, distribution, me- tabolism, and excretion, have been ...and Drug Administration regula- tory action likely will ensure continued accumulation of pediatric ...

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The Role of Drug Transporters in Statin-Induced Myopathy

The Role of Drug Transporters in Statin-Induced Myopathy

... It is well known that ethnicity may affect drug disposition and response. In the case of statins, many believe that Asians need lower statin doses because of a lower body mass index (BMI). In fact, most ...

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Lung targeted receptor occupancy by drug inhalation : an experimental and computational evaluation

Lung targeted receptor occupancy by drug inhalation : an experimental and computational evaluation

... Drug molecules are absorbed across the epithelium both via passive and active transport ...The drug transport of lipophilic compounds across the cellular barriers is generally considered to rely on ...

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Eliminating suffering through the birth of metta  : a critical hermeneutic inquiry of the identity and ethical intention of selected monks of Burma

Eliminating suffering through the birth of metta : a critical hermeneutic inquiry of the identity and ethical intention of selected monks of Burma

... positive disposition in overall critical-thinking disposition; however, students with RN license at entry had a higher overall CCTDI mean than those students without RN license upon ...

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Cultivating Critical Thinking Skill In  Teaching And Learning   And Learning Process

Cultivating Critical Thinking Skill In Teaching And Learning And Learning Process

... thinking disposition , locus of control, gender, major and class rank using a sample of 66 undergraduates recruited from introductory political sciences class at Truman State University, we found that, contrary to ...

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Involving end users in the design of an audit and feedback intervention in the emergency department setting – a mixed methods study

Involving end users in the design of an audit and feedback intervention in the emergency department setting – a mixed methods study

... A variety of concerns were brought up during the inter- views. A performance dashboard might increase phys- ician stress levels, dehumanize the patient experience, and potentially negatively affect the quality and safety ...

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Comparative Analysis between Five Level Conventional and Modified Cascaded H-Bridge Five Level Inverter Using Multicarrier Pulse width Modulation Techniques.

Comparative Analysis between Five Level Conventional and Modified Cascaded H-Bridge Five Level Inverter Using Multicarrier Pulse width Modulation Techniques.

... Phase Disposition, Phase Opposition Disposition and Alternate Phase Opposite Disposition implemented on five level conventional and modified cascaded h-bridge inverters in MATLAB/SIMULINK ...

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Harmonic Distortion Elimination for STATCOM Application Using SHE PWM Cascaded Multilevel Inverter

Harmonic Distortion Elimination for STATCOM Application Using SHE PWM Cascaded Multilevel Inverter

... well-known disposition methods, specifically alternative phase disposition, in phase disposition (IPD), and phase opposite disposition ...

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Sentencing Disparities in the Juvenile Justice System

Sentencing Disparities in the Juvenile Justice System

... We thus conclude that the most parsimonious model for describing the variables under study is the one that contains the interactions between race and disposition, SES and disposition, th[r] ...

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