Drug-induced liver injury
Drug-induced liver injury
... Drug-induced liver injury (DILI) remains the most common cause of acute liver failure (ALF) in the western ...culprit drug be discontinued, especially in the presence of ...
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Drug-induced liver injury: the dawn of biomarkers?
... Drug-induced liver injury: the dawn of biomarkers? Weiler, Stefan ; Merz, Michael ; Kullak-Ublick, Gerd A Abstract: Drug-induced liver injury (DILI) is a ...
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Chemical and biochemical aspects of drug-induced liver injury
... Adverse drug reactions (ADRs) are a major obstacle for the development of new ...systems, drug induced liver injury has lead to the withdrawal of several drugs at the post licensing ...
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The diagnosis and management of idiosyncratic drug‐induced liver injury
... Drug- induced liver injury (DILI) is an uncommon but important cause of liver disease that can arise after exposure to a multitude of drugs and herbal and dietary supple- ...severe ...
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Mechanistic regulation of HMGB1 function in drug-induced liver injury
... ix Drug-induced liver injury (DILI) is a major cause of attrition during drug development, and also a leading cause of hospital ...APAP-induced liver injury (AILI), ...
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New approaches to improve prediction of drug-induced liver injury
... of liver injury was assessed in rats treated with drug candidates that were dropped from further development, in part due to toxic adverse effects in the ...to liver injury and thus ...
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Immune-Mediated Drug Induced Liver Injury: A Multidisciplinary Approach
... immune-mediated drug-induced liver injury ...the drug progresses from preclinical animal studies into human clinical ...adverse drug reactions (ADRs). Hence drug ...
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Incidence and Etiology of Drug-Induced Liver Injury in Mainland China
... of Drug-Induced Liver Injury in Mainland China Tao Shen, MD, PHD, Yingxia Liu, MD, PHD, Jia Shang, MD, Qing Xie, MD, PHD, Jun Li, MD, Ming Yan, MD, Jianming Xu, MD, Junqi Niu, MD, Jiajun Liu, ...
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Role of hepatic transport proteins in drug disposition and drug-induced liver injury
... Elevated glutathione concentrations in Mrp2-deficient rats appear to play a protective role in acetaminophen-induced hepatotoxicity; a similar effect also would be expected for other electrophiles in ...
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Drug-induced liver injury: Interactions between drug properties and host factors
... Drug-induced liver injury: Interactions between drug properties and host factors Minjun Chen 1, , Ayako Suzuki 2,3, , Jürgen Borlak 4 , Raúl ...and Drug Administration, ...
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Death and liver transplantation within 2 years of onset of drug‐induced liver injury
... Drug-induced liver injury (DILI) is an important cause of death and indication for liver transplantation ...US Drug-Induced Liver Injury Network prospective ...
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Death and Liver Transplantation within Two Years of Onset of Drug-Induced Liver Injury
... acute liver injury without long-term ...the injury or require liver transplantation (referred hereafter as a death, mortality, fatality or fatal ...of drug-induced liver ...
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Clinical factors predicting drug-induced liver injury due to flucloxacillin
... 1,2 Drug-induced liver injury (DILI) is a collective term of differ- ent liver injuries as adverse drug reactions (ADRs) due to various ...the drug, 4–6 and due to their ...
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Guidance for Industry Drug-Induced Liver Injury: Premarketing Clinical Evaluation
... irreversible liver failure that is fatal or requires liver ...such drug- induced liver injury (DILI) can be obtained and evaluated during drug ...typical drug ...
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A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury
... for Drug Safety Sciences, Research Triangle Park, North Carolina BACKGROUND & AIMS: We performed genetic analyses of a multiethnic cohort of patients with idiosyncratic drug-induced liver ...
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Investigating the role of reactive metabolites and parent compound in drug induced liver injury
... Adverse drug reactions (ADRs) are a major problem for drug companies and healthcare providers ...the liver frequently effected, due to the relatively large concentrations of drugs it ...encounters. ...
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Investigating the role of reactive metabolites and parent compound in drug induced liver injury
... Adverse drug reactions (ADRs) are a major problem for drug companies and healthcare providers ...the liver frequently effected, due to the relatively large concentrations of drugs it ...encounters. ...
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Matrix factorization-based data fusion for drug-induced liver injury prediction
... 5 Conclusion Data fusion allows us to simultaneously consider the available data for outcome prediction of drug-induced liver injury. Its models can surpass accuracy of standard machine learn- ...
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Drug-induced liver injury in hospitalized patients with notably elevated alanine aminotransferase
... Background Drug-induced liver injury (DILI) is being increasingly recognized as an impor- tant cause of acute hepatic ...acute liver failure in several Western countries and the most ...
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Recent progress in genetic variation and risk of antituberculosis drug-induced liver injury
... Antituberculosis drug-induced liver injury (ATDILI) is the most prevalent hepatotoxicity in many ...major drug- metabolizing enzyme of isoniazid is N-acetyltransferase ...corresponding ...
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