Drug-induced QT prolongation
Use of Human Embryonic Stem Cell Derived Cardiomyocyte Clusters to Assess Potential for Chronic Treatment with Compounds to Cause QT Prolongation
... Drug-induced QT prolongation is a serious clinical issue in developing novel drug candidates and marketing ...of QT prolongation is direct inhibition of human ...
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Identification of Patients At Risk of QT Interval Prolongation during Medication Reviews: A Missed Opportunity?
... for QT interval prolongation, the following factors were evaluated: increased age (>65 years), female gender, smoking status, obesity (body mass index ≥ 30 kg/m 2 ), cardiomyopathy, hypertension, ...
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Drug-induced prolonged corrected QT interval in patients with methadone and opium overdose
... All patients with methadone or opium toxicity admit- ted to the Vasei hospital, Sabzevar, Iran, during the years 2015 and 2016, with toxicity confirmed by urine screen test, were included in this study. Initially, the ...
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Multivariate analysis of risk factors for QT prolongation following subarachnoid hemorrhage
... The present findings suggest that female sex and hypokalemia are independent risk factors for severe QTc pro- longation in patients with SAH. Recent clinical observations and experimental data indicate sex-specific ...
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Drug-drug interactions and QT prolongation as a commonly assessed cardiac effect - comprehensive overview of clinical trials
... of drug-induced ...a drug to block ion currents and disturb electrophysiological activity of cardiac myocytes, but also by many other factors modifying individual risk of QT ...
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Choice of baseline in a multiple-dose thorough QT study (TQTS) – effect on analysis of moxifloxacin-induced QTc prolongation
... “thorough QT/QTc” study (TQTS) to measure the effect of a drug on the QT interval early in development to determine the need for intensive QT monitoring during later devel- ...the QT ...
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Assessment of Interspecies Differences in Drug-Induced QTc Interval Prolongation in Cynomolgus Monkeys, Dogs and Humans.
... affect QT interval, which will decrease irrespective of drug levels, as can be seen in the moxifloxacin data ...food-induced QT decrease, but residual differences may mask the intrinsic ...
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A literature-based algorithm for the assessment, management, and monitoring of drug-induced QTc prolongation in the psychiatric population
... corrected QT (QTc) interval on the electrocardiogram, which puts patients at risk of life-threatening ventricular arrhythmias such as torsades de ...for drug-induced QTc prolongation is more ...
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Disease associated QT shortage versus quinine associated QT prolongation: age dependent ECG effects in Ghanaian children with severe malaria
... corrected QT inter- vals: Many formulas have been proposed to correct QT intervals for the heart rate [14,15,30,31] but none is com- pletely ...the QT interval in high heart rates it was considered ...
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QT Interval in Children and Infants Receiving Cisapride
... develop QT prolongation as judged by follow-up ...to prolongation of QT interval despite prolonged use, and QTc interval was similar for premature and older children at baseline and during ...
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Effects of anti malarial drugs on the electrocardiographic QT interval modelled in the isolated perfused guinea pig heart system
... Other reports showed that the unbound therapeutic plasma concentration was 0.57 μ M [22]. According to the results of this study, these reportedly low concentra- tions in humans do not seem to lengthen the QT ...
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Psychotropic drug prescribing in an Australian specialist child and adolescent eating disorder service: a retrospective study
... The study received approval from the PMH Human Re- search Ethics Committee as a quality of care audit. A purpose designed paper form was used to collect infor- mation retrospectively from the medical file and psychi- ...
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Torsades de pointes during laparoscopic adrenalectomy of a pheochromocytoma: a case report
... Pheochromocytomas are catecholamine-producing neu- roendocrine tumors arising from the chromaffin cells of the adrenal medulla or extraadrenal paraganglia. A pheochromocytoma is a potential life-threatening dis- ease ...
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Antenatal Use of Selective Serotonin-Reuptake Inhibitors and QT Interval Prolongation in Newborns
... 29 milliseconds; P ⫽ .02). The mean uncorrected QT interval was 7.5% longer (280 ⫾ 31 vs 261 ⫾ 25 milli- seconds; P ⬍ .001), and the mean JT interval was 10% longer (229 ⫾ 30 vs 209 ⫾ 24 milliseconds; P ⬍ .001) ...
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A study of myocardial injury in organophosphorous poisoning.
... Clinical Significance The incidence of ECG QT Prolongation Positivity among patients treated for myocardial injury in organophosphorous compound poisoning was meaningfully less5.00% in p[r] ...
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Diagnostic Accuracy of Screening Electrocardiograms in Long QT Syndrome I
... and QT intervals for every beat in all 12 ...each QT interval was measured from the onset of the QRS complex to the termination of the T wave (the point at which the descending limb of the T wave intersects ...
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The E1784K mutation in SCN5A is associated with mixed clinical phenotype of type 3 long QT syndrome
... Phenotypic overlap of type 3 long QT syndrome (LQT3) with Brugada syndrome (BrS) is observed in some carriers of mutations in the Na channel SCN5A. While this overlap is important for patient management, the ...
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Long QT syndrome, Brugada syndrome, and conduction system disease are linked to a single sodium channel mutation
... and III-10; Figure 1). Evaluation of their descendants identified eight additional mutation carriers, four of whom had a history of syncopal events of unknown etiology. Seven individuals presented with a pro- longed ...
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Solid dispersion matrix tablet comprising indomethacin-PEG-HPMC fabricated with fusion and mold technique
... diffusion-controlled drug release) and n = ...coupled drug diffusion in the hydrated matrix and polymer relaxation), commonly called anomalous non- Fickian transport [34] ...
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Morphological and Electrical Characteristics in Patient with Hypertrophic Cardiomyopathy: Quantitative Analysis of 864 Korean Cohort
... Results: Of 864 patients (mean age 55.4±14.2 years, 68.9% men), 255 (29.5%) patients had apical HCM, 553 (64.0%) patients asym- metric HCM, and 56 (6.4%) patients mixed type HCM. In echocardiographic evaluations, about ...
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