Dynamin-related protein(Opa1)
Activation of dynamin-related protein 1 - dependent mitochondria fragmentation and suppression of osteosarcoma by cryptotanshinone
... Mitochondria play an important role in the production of energy within cells, and are essential in the regulation of cellular life and death. In most healthy mammalian cells, mitochondria exhibit tubular, reticular, or ...
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SENP3-mediated deSUMOylation of dynamin-related protein 1 promotes cell death following ischaemia
... Severe ischaemia causes cell death through cytochrome c release into the cytosol, which leads to caspase cleavage and apoptosis. Cytochrome c can be released by mitochondrial fission (Wilson et al, 2013) and/or via ...
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Dynamin-Related Protein 1-Dependent Mitochondrial Fission Changes in the Dorsal Vagal Complex Regulate Insulin Action
... Mitochondria undergo dynamic changes to maintain function in eukaryotic cells. Insulin action in parallel regulates glucose homeostasis, but whether specific changes in mitochondrial dynamics alter insulin action and ...
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Dynamin-related protein 1 is involved in micheliolide-induced breast cancer cell death
... Drp1 protein expressions in (C) McF-7 and (D) MDa-MB-231 cells were detected by Western ...Drp1, dynamin-related protein 1; WT, wild type; EGFP, enhanced green fluorescent ...
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Phytophthora infestans RXLR WY Effector AVR3a Associates with Dynamin Related Protein 2 Required for Endocytosis of the Plant Pattern Recognition Receptor FLS2
... GTPase dynamin-related protein (DRP) ...mammals, dynamin is a five-domain protein consisting of a GTPase domain, an unstructured middle domain, a Pleckstrin-homology domain, a GTPase ...
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Resistance of Dynamin-related Protein 1 Oligomers to Disassembly Impairs Mitophagy, Resulting in Myocardial Inflammation and Heart Failure
... gene Dynamin-related protein 1 (Drp1) underlies the Python mouse model of monogenic dilated car- ...Drp1 protein function and to define the cellular sequelae leading to heart failure in the ...
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Downregulation of mitochondrial cyclooxygenase-2 inhibits the stemness of nasopharyngeal carcinoma by decreasing the activity of dynamin-related-protein 1
... mitochondrial dynamin-related protein 1 (Drp1), a mitochondrial fission mediator, by studying both sorted SP cells from NPC cell lines and gene expression analyses in NPC ...stemness, ...
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Dynamin-related protein Drp1 is required for Bax translocation to mitochondria in response to irradiation-induced apoptosis
... protease inhibitor cocktails (Sigma). To extract cytosolic fraction (fraction 1), DLBCL cells were suspended into the buffer 1 which contains 0.02% digitonin, which only permeabilizes the plasma membrane and incubated on ...
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Peroxisome proliferator-activated receptor-gamma dependent pathway reduces the phosphorylation of dynamin-related protein 1 and ameliorates hippocampal injury induced by global ischemia in rats
... p-Drp1(Ser616) protein level in hippocampal CA1 subfield 24 h after TGI, which was reduced by pio- glitazone pretreatment; moreover, GW9662 reversed the pioglitazone effect over p-Drp1(Ser616) protein ...
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Phosphorylation Regulates the Endocytic Function of the Yeast Dynamin-Related Protein Vps1
... In mammalian cells, it is clear that phosphorylation in the C- terminal PRD region of dynamin is important for interactions with a number of endocytic proteins, including the BAR domain proteins amphiphysin and ...
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Genetic communication by extracellular vesicles is an important mechanism underlying stem cell-based therapy-mediated protection against acute kidney injury
... of dynamin-related protein-1 (DRP-1) and mitochondrial fragmentation induced by I/R-induced AKI, which led to antiapoptotic and renoprotective effects ...
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Berberine Protects Glomerular Podocytes via Inhibiting Drp1-Mediated Mitochondrial Fission and Dysfunction
... (S616) protein expression in glomerular ...Drp1, dynamin-related protein 1; TEM, transmission electron micrograph; Mid51 and Mid49, mitochondrial dynamics proteins of 51 and 49 kDa; Fis1, ...
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Calcium signaling around Mitochondria Associated Membranes (MAMs)
... As described above, mitochondria and endoplasmic reti- culum networks are fundamental for the maintenance of calcium homeostasis. Recently, different studies have documented the crucial role that MAMs play in intra- ...
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Linking F-box protein 7 and parkin to neuronal degeneration in Parkinson’s disease (PD)
... can ubiquitinate itself in concert with its many mitochon- drial substrates. The PINK1 induced phosphorylation of Ub conjugated to Parkin substrates can trigger further cy- cles of Parkin recruitment and activation. This ...
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Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models
... inhibitors. Dynamin-related protein 1 (Drp1), a critical mitochondrial fission protein, translocated to mitochondria early during tubular cell injury, and both siRNA knockdown of Drp1 and ...
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Synthetic Genetic Interactions With Temperature-Sensitive Clathrin in Saccharomyces cerevisiae: Roles for Synaptojanin-Like Inp53p and Dynamin-Related Vps1p in Clathrin-Dependent Protein Sorting at the trans-Golgi Network
... selective protein transport at the Golgi apparatus and the plasma ...clathrin-mediated protein transport path- ways, we initiated a genetic screen for mutations that display synthetic growth defects when ...
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Functional analysis of the Rac-binding protein POSH
... epsin-like protein {liquid facets), as well as to a proteasome component [Huang, 1995] [Cadavid, ...a protein for degradation by the proteasome, reviewed in [Weissman, ...a protein for proteasomal ...
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Dynasore - not just a dynamin inhibitor
... intracellular protein with essential roles in membrane remodelling and fission of clathrin-coated vesicles formed during endocytosis, and vesicles that bud from the trans-Golgi network ...on dynamin for the ...
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Identification and Partial Characterization of a Dynamin-Like Protein, EhDLP1, from the Protist Parasite Entamoeba histolytica
... of protein from all the fractions were resolved by SDS-PAGE, transferred onto PVDF membranes, and immunoblotted with anti-EhDLP1 as the primary antibody and anti-rabbit horseradish peroxidase as the secondary ...
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Systematicness of glomalin in roots and mycorrhizosphere of a split-root trifoliate orange
... root protein showed a systematic increase in non-mycorrhiza-inoc- ulated chamber under inoculation with ...soil protein and total glomalin-related soil protein as a result of ...
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