E-selectin ligand 1
E selectin ligand–1 regulates growth plate homeostasis in mice by inhibiting the intracellular processing and secretion of mature TGF β
... of ligand-receptor ...protein, E-selectin ligand–1 (ESL-1), acts as a negative regulator of TGF-β production by binding TGF-β precursors in the Golgi apparatus in a ...
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The cytokine adhesion molecule cascade in ischemia/reperfusion injury of the rat kidney Inhibition by a soluble P selectin ligand
... of E-selectin mRNA in the ...not E-selectin, sPSGL was digested with the snake venom protease, ...bind E-selectin ...both E-selectin induction and PMN in- flux 6 h ...
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Generation of soluble P and E selectins in vivo is dependent on expression of P selectin glycoprotein ligand 1
... tracking ligand– selectin interactions in ...that selectin shedding may play an important regulatory role in leukocyte adhesive interactions with endothelial ...
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Neutrophil adhesion in leukocyte adhesion deficiency syndrome type 2
... type 1 (LAD I), but the two syndromes differ in the molecular basis of their adhesion ...carbohydrate ligand for ...recombinant E-selectin, purified platelet P-selectin, or ...
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Neutrophils use both shared and distinct mechanisms to adhere to selectins under static and flow conditions
... glycoprotein ligand-1 (PSGL-1) and L-selectin are localized on the microvilli of neutrophils and have been implicated in the attachment of neutrophils to P-selectin or E- ...and ...
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Memory B lymphocytes from secondary lymphoid organs interact with E selectin through a novel glycoprotein ligand
... dNTP, 0.5 mM specific sense and antisense primers, and 2.5 U Taq polymerase (Perkin-Elmer Corp., Norwalk, Connecticut, USA) were carried out with cycle parameters as follows: 1 minute at 94°C, 1 minute at ...
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Neutrophil neutrophil interactions under hydrodynamic shear stress involve L selectin and PSGL 1 A mechanism that amplifies initial leukocyte accumulation of P selectin in vitro
... of selectin-ligand bond formations are de- creased ...P-selectin ligand density was not reduced on DREG200- treated ...(# 1 min, Fig 4 a) similar numbers of untreated and ...
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Valproic acid attenuates intercellular adhesion molecule-1 and E-selectin through a chemokine ligand 5 dependent mechanism and subarachnoid hemorrhage induced vasospasm in a rat model
... Despite cerebral vasospasm following SAH has been rec- ognized for more than half a century, the outcome of SAH patients revealed devastating, and stood still after decades of research and treatment on cerebral vaso- ...
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P selectin glycoprotein ligand 1–deficient mice have impaired leukocyte tethering to E selectin under flow
... Generation of PSGL-1–deficient mice. Electroporation was used to transfect the targeting vector into CJ7 ES cells (originating in a 129/SvlmJ mouse, a gift from Thomas Sato, University of Texas Southwestern Med- ...
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Selectin and selectin ligand binding: a bittersweet attraction
... neous lymphocyte-associated antigen (CLA), binds to all three selectins and appears to be an interesting drug tar- get. Its expression by T cells requires the action of multiple glycosyltrans- ferases such as core 2 β ...
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Vasculopathy and disordered angiogenesis in selected rheumatic diseases: rheumatoid arthritis and systemic sclerosis
... fibroblasts, E-selectin and P-selectin in skin, ET-1 in monocytes and skin fibroblasts, and monocyte chemoattractant molecule-1/CC chemokine ligand 2 in different cell types in ...
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The anti-inflammatory effect of kaempferol on early atherosclerosis in high cholesterol fed rabbits
... of E-sel, ICAM-1, VCAM-1 and MCP-1 expression were pictured in Figure ...contrary, E-sel, ICAM-1, VCAM-1 and MCP- 1 were strongly expressed in model rabbits fed ...
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Gauß, Alexandra (2008): Der Einfluss des Adhäsionsmoleküls GPVI-aCD133 auf die Adhäsion von endothelialen Progenitorzellen in zwei Gefäßverletzungsmodellen der Maus: Untersuchungen mit Hilfe der Intravitalmikroskopie. Dissertation, LMU München: Tierärztliche Fakultät
... Während aktivierte Thrombozyten über P-Selektin mit PSGL-1 (P-selectin glycoprotein ligand-1) der CD34 + Progenitorzellen interagieren und den Prozess des Rollens vermitteln, [r] ...
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E-selectin and vascular cell adhesion molecule-1 as biomarkers of 3-month outcome in cerebrovascular diseases
... measuring E-selectin and vascular cell adhesion molecule-1 (VCAM-1) has only been de- scribed for predicting nearest evolution of stroke during acute phase, but it has never been assessed for ...
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Selectin ligands: will the real ones please stand up?
... In no other instance has the criteria for a real selectin ligand been completely fulfilled. Those that come the closest are considered below. GlyCAM-1 is a small mucin-type glyco- protein that, when ...
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Journal of Applied Pharmaceutical Science
... of E-selectin in case of cancer may be a prognostic marker in the course of many neoplastic diseases (Siegel and Malmsten, ...of E- selectin ligand which is sialyl Lewis X on their cell ...
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Heparin’s anti inflammatory effects require glucosamine 6 O sulfation and are mediated by blockade of L and P selectins
... these selectin inhibitors have various drawbacks, such as narrow cross-reactivity, weak affinity, relatively little selectivity among the selectins, short circulating half-life, great expense to produce in the ...
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Early Clinical Markers for the Development of Bronchopulmonary Dysplasia: Soluble E-Selectin and ICAM-1
... at 1 and 5 minutes and the development of BPD, and by post hoc testing Apgar scores at both 1 and 5 minutes were higher in the infants that did not develop BPD than in the infants that did develop ...at ...
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Serum ICAM-1, VCAM-1 and E-selectin levels in patients with primary and secondary Sjögren’s syndrome
... recruited consecutively in 2013 from the Department of Rheumatology and Clinical Immunology at Poznan University of Medical Sciences, Poland. Exclusion crite- ria included: previous radiotherapy to the head and neck, ...
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Role of ICAM-1 and E-selectin gene polymorphisms in pathogenesis of PAOD in Egyptian patients
... concurrent E-selectin and ICAM-1 genotypes in patients with PAOD with a normal control group and observed no significant association between AC and EE ...the E-selectin gene and EE ...
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