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early-onset breast cancer

GT198 (PSMC3IP) germline variants in early-onset breast cancer patients from hereditary breast and ovarian cancer families

GT198 (PSMC3IP) germline variants in early-onset breast cancer patients from hereditary breast and ovarian cancer families

... with early cancer onset and in one patient with apparently sporadic early-onset breast cancer ...in breast and ovarian cancers and in fallopian tube tumors ...

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BRCA1 mutations in women with familial or early-onset breast cancer and BRCA2 mutations in familial cancer in Estonia

BRCA1 mutations in women with familial or early-onset breast cancer and BRCA2 mutations in familial cancer in Estonia

... with early-onset breast cancer diag- nosed before the age of 45, and 47 familial cases consist- ing of patients with breast or ovarian cancer and at least one family member ...

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Original Article Polymorphism in the second intron of the FGFR2 gene rs1219648 associated with the early-onset breast cancer in Turkish population

Original Article Polymorphism in the second intron of the FGFR2 gene rs1219648 associated with the early-onset breast cancer in Turkish population

... in breast cancer within populations with various ethnic groups ...for breast cancer in GWAS studies ...for breast cancer by increasing FGFR2 gene expression via caus- ing ...

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Comparable frequency of BRCA1, BRCA2 and TP53 germline mutations in a multi ethnic Asian cohort suggests TP53 screening should be offered together with BRCA1/2 screening to early onset breast cancer patients

Comparable frequency of BRCA1, BRCA2 and TP53 germline mutations in a multi ethnic Asian cohort suggests TP53 screening should be offered together with BRCA1/2 screening to early onset breast cancer patients

... female breast cancer, bone or soft tissue sarcomas, brain tumors and adrenocortical carcinomas (ACC) ...with early-onset breast cancer aged 40 years and below ...

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Novel mutations in the BRCA1 and BRCA2 genes in Iranian women with early-onset breast cancer

Novel mutations in the BRCA1 and BRCA2 genes in Iranian women with early-onset breast cancer

... Background: Breast cancer is the most common female malignancy and a major cause of death in middle-aged ...with early-onset breast and/or ovarian cancer have not been identified ...

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Cancer incidence in relatives of a population based set of cases of early onset breast cancer with a known BRCA1 and BRCA2mutation status

Cancer incidence in relatives of a population based set of cases of early onset breast cancer with a known BRCA1 and BRCA2mutation status

... of cancer risk among individuals of those mutation- negative families for which mutation status will provide no further information; at our institute, almost three-quarters of the analysed families (unpublished ...

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Increased genomic burden of germline copy number variants is associated with early onset breast cancer: Australian breast cancer family registry

Increased genomic burden of germline copy number variants is associated with early onset breast cancer: Australian breast cancer family registry

... known breast cancer susceptibility gene, BRCA1 , in a woman diagnosed with infiltrating ductal carcinoma of the breast (grade 3) at the age of 39 years, who did not have a family history of the ...

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BIRC5 Genomic Copy Number Variation in  Early-Onset Breast Cancer

BIRC5 Genomic Copy Number Variation in Early-Onset Breast Cancer

... Although cancer is not prevalent in individuals under the age of 40, the incidence of the disease at a younger age may increase the risk of recurrence [18] .... Breast cancer in young women is more ...

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Germline DNA copy number variation in familial and early onset breast cancer

Germline DNA copy number variation in familial and early onset breast cancer

... in cancer is listed in Additional file ...among cancer patients represent common CNVs in the Brazilian population, we compiled CNV data obtained from independent samples studied in our laboratory using 180 ...

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Effect of reproductive factors on stage, grade and hormone receptor status in early onset breast cancer

Effect of reproductive factors on stage, grade and hormone receptor status in early onset breast cancer

... of breast tissue that occurs during a full-term ...with breast cancer before age 35 years, increased par- ity and an early age at first full-term pregnancy are associated with more advanced ...

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Contribution of large genomic BRCA1 alterations to early-onset breast cancer selected for family history and tumour morphology: a report from The Breast Cancer Family Registry

Contribution of large genomic BRCA1 alterations to early-onset breast cancer selected for family history and tumour morphology: a report from The Breast Cancer Family Registry

... BCFR participants have undergone extensive testing for BRCA1 and BRCA2 mutations using techniques described previously [8,17,19], including two-dimensional gel scanning, denaturing high-performance liquid chro- ...

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Increased circulating resistin levels in early onset breast cancer patients of normal body mass index correlate with lymph node negative involvement and longer disease free survival: a multi center POSH cohort serum proteomics study

Increased circulating resistin levels in early onset breast cancer patients of normal body mass index correlate with lymph node negative involvement and longer disease free survival: a multi center POSH cohort serum proteomics study

... with early-stage (T1 – T3) invasive breast carcinoma, diagnosed between January 2000 and December 2007 from the Prospective study of Outcomes in Sporadic versus Hereditary breast cancer (POSH) ...

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A common missense variant in BRCA2 predisposes to early onset breast cancer

A common missense variant in BRCA2 predisposes to early onset breast cancer

... invasive breast cancer and one case of DCIS were observed ...common early steps in the development of invasive breast cancer in BRCA2 ...greater breast cancer risk in ...

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Molecular genetics analysis of hereditary breast and ovarian cancer patients in India

Molecular genetics analysis of hereditary breast and ovarian cancer patients in India

... follows: Early onset of breast cancer (≤35 years of age) or ovarian cancer (≤40 years of age); Two cases of breast cancer diagnosed under the age of 50 years in a family ...

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Triple negative breast cancer and PTEN (phosphatase and tensin homologue)loss are predictors of BRCA1 germline mutations in women with early onset and familial breast cancer, but not in women with isolated late onset breast cancer

Triple negative breast cancer and PTEN (phosphatase and tensin homologue)loss are predictors of BRCA1 germline mutations in women with early onset and familial breast cancer, but not in women with isolated late onset breast cancer

... whom early-onset breast cancer develops and in women with a family history of breast and ovarian can- ...develop early-onset triple-negative basal-like breast ...

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The DNMT3B C→T promoter polymorphism and risk of breast cancer in a British population: a case control study

The DNMT3B C→T promoter polymorphism and risk of breast cancer in a British population: a case control study

... with early-onset breast cancer, bilateral breast cancer and/or with a family history of breast cancer has suggested that individuals car- rying one or more C ...

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Triple negative breast cancer and PTEN (phosphatase and tensin homologue)loss are predictors of BRCA1 germline mutations in women with early onset and familial breast cancer, but not in women with isolated late onset breast cancer

Triple negative breast cancer and PTEN (phosphatase and tensin homologue)loss are predictors of BRCA1 germline mutations in women with early onset and familial breast cancer, but not in women with isolated late onset breast cancer

... whom early-onset breast cancer develops and in women with a family history of breast and ovarian can- ...develop early-onset triple-negative basal-like breast ...

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The importance of BRCA1 and BRCA2 genes mutations in breast cancer development

The importance of BRCA1 and BRCA2 genes mutations in breast cancer development

... for breast cancer Ethnic and geographical differences in the incidence of breast cancer demonstrate the effect of environmental conditions and life- ...for breast cancer. These ...

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Brain Metastasis as an Initial Manifestation of Ovarian Carcinoma: A Case Report

Brain Metastasis as an Initial Manifestation of Ovarian Carcinoma: A Case Report

... for cancer. With another point of view, up to 10% of ovarian cancer patients carry BRCA1/2 mutations ...of early onset developing breast cancer with a lifetime risk of 56% to 84% ...

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Involvement of hedgehog pathway in early onset, aggressive molecular subtypes and metastatic potential of breast cancer

Involvement of hedgehog pathway in early onset, aggressive molecular subtypes and metastatic potential of breast cancer

... of breast cancer in Pakistani women, devising novel therapeutic strategies are an absolute ...younger breast cancer patients including hedgehog inhibitors in adju- vant therapy ...

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