Ebola virus VP35
The Host E3-Ubiquitin Ligase TRIM6 Ubiquitinates the Ebola Virus VP35 Protein and Promotes Virus Replication
... with Ebola virus VP35 ...EBOV VP35 previously has been shown to interact with and inhibit IKK (20), we hypothesized that this inhibition occurs by interfering with TRIM6 ...with VP35 ...
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Ebola Virus VP35 Protein Binds Double-Stranded RNA and Inhibits Alpha/Beta Interferon Production Induced by RIG-I Signaling
... 1. Ebola virus VP35 binds to ...(WB: VP35) monoclonal ...the VP35 mutants, increasing amounts of lysates from cells expressing wild-type VP35 (VP35) or a VP35 ...
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Ebola Virus VP35 Antagonizes PKR Activity through Its C-Terminal Interferon Inhibitory Domain
... of VP35 for any of the tested constructs (Fig. 1B), indicating that VP35 enhances ectopic gene expression independently of the used promoter and the expression ...by VP35 could be visualized by ...
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Ebola Virus VP35-VP40 Interaction Is Sufficient for Packaging 3E-5E Minigenome RNA into Virus-Like Particles
... VP40, VP35, and the 3E-5E minigenome at the edges of the cell, presumably just under the plasma membrane ...the Ebola virus-derived regions of the 3E-5E minigenome to the formation of EBOV RNP ...
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Characterization of the RNA Silencing Suppression Activity of the Ebola Virus VP35 Protein in Plants and Mammalian Cells
... plant virus- silencing suppressor under HCMV promoter control (39) and was the kind gift of Kathy Boris-Lawrie (Ohio State ...EBOV VP35 gene (Zaire) was the kind gift of Chris Basler ...the VP35 ORF ...
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Ebola Virus VP35 Interaction with Dynein LC8 Regulates Viral RNA Synthesis
... WT VP35 were used ...that VP35 expression levels were similar for each condition and confirmed LC8 expression ...When VP35 mutants T73A and Q74A were tested, each exhibited reduced activity compared ...
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Different Temporal Effects of Ebola Virus VP35 and VP24 Proteins on Global Gene Expression in Human Dendritic Cells
... Ebola virus (EBOV) causes a severe hemorrhagic fever with a deficient immune response, lymphopenia, and lymphocyte apopto- ...EBOV VP35 and VP24 by the mutations R312A and K142A, ...of VP35 ...
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The VP35 Protein of Ebola Virus Inhibits the Antiviral Effect Mediated by Double-Stranded RNA-Dependent Protein Kinase PKR
... with Ebola virus, the VP35 protein may serve to block the activation of PKR and thereby abrogate the first line of host ...the VP35 protein provides a favorable environment for viral infec- ...
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Crystal Structure of the Marburg Virus VP35 Oligomerization Domain
... Marburg virus can cause severe disease, with up to 90% human le- ...proteins, VP35, is essential for replication of the viral genome and for evasion of host immune ...responses. VP35 oligomerizes ...
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Inhibition of IRF-3 Activation by VP35 Is Critical for the High Level of Virulence of Ebola Virus
... by Ebola virus is critical for the design of therapeutics and vaccines against the ...progression, virus interaction with the innate immune system early in the course of infection likely plays an ...
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Newcastle Disease Virus (NDV)-Based Assay Demonstrates Interferon-Antagonist Activity for the NDV V Protein and the Nipah Virus V, W, and C Proteins
... Nipah virus V, W, and C proteins can prevent establishment of an IFN-induced antiviral ...a virus that is susceptible to the antiviral effects of IFN, although it encodes a functional IFN antagonist, the V ...
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Curability of Ebola Virus – A Scientometric Approach to Ebola Virus Research
... treatments, Ebola outbreak management has been limited to palliative care and barrier methods to prevent ...2014 Ebola virus disease (EVD, or “Ebola”) outbreak in West Africa was conducted ...
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Assessment of the Potential for Spread of Deadly Ebola Virus across International Borders by Returnee Travelers and Humanitarian Health Workers from West Africa
... Abstract The recent Ebola Virus Disease (EVD) outbreak in West Africa is so far the largest and deadliest in recorded history. The rapid spread of the disease in the region and its potential for ...
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Human Ebola virus infection in West Africa: a review of available therapeutic agents that target different steps of the life cycle of Ebola virus
... The virus- associated GP1,2 and not the other soluble glycoproteins released during the virus infection are responsible for pri- mary target cell activation ...
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Reverse Genetics Demonstrates that Proteolytic Processing of the Ebola Virus Glycoprotein Is Not Essential for Replication in Cell Culture
... for Ebola virus ...with Ebola GPs as well as the present results demonstrate that GP cleavage is dispens- able for replication of Ebola virus, at least in cell ...all Ebola GP ...
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A Study of the Ebola Virus Glycoprotein: Disruption of Host Surface Protein Function and Evasion of Immune Responses
... during Ebola infection (reviewed in ...during Ebola infection [4,11]. Finally, loss of adhesion by Ebola GP has been shown to cause anoikis in primary endothelial cells ...
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Heparan sulfate is an important mediator of Ebola virus infection in polarized epithelial cells
... initial virus attachment to the cell surface ...simplex virus, and influ- enza A virus, and a similar strategy can be explored for EBOV [33 – ...
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Mutational Analysis of the Putative Fusion Domain of Ebola Virus Glycoprotein
... the Ebola virus GP. The Ebola virus GP is cleaved at amino acid position 501 into GP1 and GP2 by furin (23, ...wild-type Ebola virus GP and its ...expressing Ebola ...
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Reverse Genetic Generation of Recombinant Zaire Ebola Viruses Containing Disrupted IRF-3 Inhibitory Domains Results in Attenuated Virus Growth In Vitro and Higher Levels of IRF-3 Activation without Inhibiting Viral Transcription or Replication
... of Ebola virus containing mutations in ...the Ebola virus genome has been described previously ...the VP35 gene using the overlapping PCR ...The virus was rescued using the ...
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The_Impact_of_Culture_on_the_Spread_of_the_Ebola_Virus_Disease.pdf
... The implementation of control measures needed to take effect to stop transmission and provide clinical care for infected individuals (Ebola, 2014). Many of the measures taken were contrary to traditions. From the ...
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