Effects on smooth muscle cell
Smooth Muscle Cell Mitochondrial Respiration – Effects of Aerobic Training and Type I Diabetes
... the effects of exercise training in T1DM patients are far less extensive than it is for T2DM ...cardiac muscle, increased substrate metabolism and enhanced mitochondrial dynamics within myocytes have been ...
77
Effects of Mycophenolic Acid on Oleic Acid- induced Rat Vascular Smooth Muscle Cell Proliferation
... 흡착지를 5% non fat dry milk blocking 용액에 넣고 상온에 서 1시간 동안 반응시켰다. 0.1% Tween 20을 포함한 Tris 완충액으로 2회 세척한 후 일차 항체로 2시간 동안 반응시 킨 후 15분씩 4회 세척하였다. Proliferating-cell nuclear anti- gen (PCNA) 항체는 β-actin 항체로 보정하였다. 이차 항체 ...
6
Distinct Effects of Ca2+ Sparks on Cerebral Artery and Airway Smooth Muscle Cell Tone in Mice and Humans
... sparks on both cell types were determined by L-type voltage-dependent Ca 2+ channels (LVDCCs). In addition, compared with ASMCs, CASMCs had great and higher amplitude Ca 2+ sparks, a higher density of BKs, and ...
12
In periods of health, the vascular smooth muscle cell
... off-target effects in organ systems in which microRNA modulators assimilate to a much greater extent than the targeted vasculature, such as liver, kidney, lung, and ...or cell-type–specific deliv- ery ...
5
Smooth muscle cell phenotypic switching in atherosclerosis
... other cell types contribute to lesion development but may be mis-identified using conventional markers? We ascertain that definitive resolution of these questions is paramount to understanding mechanisms and ...
9
Smooth muscle cell-specific knockout of neuropilin-1 impairs postnatal lung development and pathological vascular smooth muscle cell accumulation
... redundancy effects due to possible compensatory upregulation of Nrp2 expression, we generated a conditional and inducible smMHC-Cre ERT2 transgenic line to allow controlled Nrp1 knockout in SMCs when crossed to ...
10
Abnormal vascular smooth muscle cell (VSMC) proliferation
... The effects of IGF-I on VSMC proliferation and directional migration are widely recognized across mammalian species. Although it is evident that the mitogenic and chemotactic actions of IGF-I are mediated through ...
9
Rapamycin inhibits vascular smooth muscle cell migration
... Fuster, A.R. Marks, and J.J. Badimon, manuscript submitted for publication). The latter study showed further that the re- duction in luminal narrowing after PTCA was due to inhibi- tion of intimal SMC hyperplasia ...
8
A genome-wide, single-cell analysis of vascular smooth muscle cell plasticity
... precise effects of dissociation-induced stress response on transcriptional profiles varied between different cell ...specific effects that the tissue dissociation approach used in our study had on ...
171
The vascular smooth muscle cell: A therapeutic target in type 2 diabetes?
... 4. Can T2DM directly influence vascular SMC phenotype? Although an immediate connection between T2DM per se and SMC phenotype is not clear, the metabolic milieu of insulin resistance and T2DM can progress for a decade or ...
32
The role of focal adhesion kinase in vascular smooth muscle cell migration
... ABSTRACT Members of the paxillin family of LIM domain-containing proteins are focal adhesion-targeted factors that play important roles in cytoskeletal remodeling and cell motility. Leupaxin, a recently identified ...
87
Endogenous laminin is required for human airway smooth muscle cell maturation
... kidney cell detachment from fibronectin and vitronectin occurs at concentrations above 1 ...the effects of GRGDSP, which were similar to that for YIGSR, cannot be exclusively attributed to the inhibition of ...
15
Regulation of human airway smooth muscle cell migration and relevance to asthma
... Corticosteroids and beta 2 agonists Corticosteroids are currently the gold standard treat- ment for airway inflammation in asthma. Goncharova et al., found that treatment with dexamethasone and fluti- casone inhibited ...
15
Troglitazone inhibits vascular smooth muscle cell growth and intimal hyperplasia
... It is unknown whether agents which inhibit VSMC growth pre- vent the development of advanced atherosclerotic lesions; thi- azolidinediones may be useful agents to address this question. This issue is particularly ...
10
Evidence for a role of collagen synthesis in arterial smooth muscle cell migration
... the smooth muscle a -actin–containing ...toxic effects of the reagents and were similar with the two mechanistically distinct collagen synthesis ...
11
Inflammation signals airway smooth muscle cell proliferation in asthma pathogenesis
... asthma patients are reported to have elevated numbers of CD4 + T (Th2 subtype) cells in the airways. These Th2 lymphocytes produce IL-4, IL-5, IL-9, and IL-13 which mediate the inflammatory response in asthmatic airways ...
5
Neutrophil mediated smooth muscle cell loss precedes allograft vasculopathy
... dendritic cell uptake and presentation to alloreactive T cells ...direct effects of IR on acute rejection, direct effects of IR-injury on late adaptive immune events, or a combination ...
11
Epigenetic regulation of COL15A1 in smooth muscle cell replicative aging and atherosclerosis
... anticipated effects and effect sizes are very differ- ent in the two datasets, we created a summary measure of evidence across the two datasets using Fisher’s formula to combine P-values for heterogeneous datasets ...
14
Signal-Dependent Transcriptional Regulation of Vascular Smooth Muscle Cell Differentiation
... repressive effects of class II histone deacetylases (HDACs) on MEF2 proteins, we ectopically expressed HDAC4, and observed repression of c-jun ...activate smooth muscle gene expression, and this ...
183
FABP4: interactions with endothelial cell plasma membrane and effects on vascular smooth muscle cells.
... Cytokeratins are known to be part of a family of intermediate fila- ment proteins that participate in cytoskeletal assembly [45] . CK1 is a member of the basic-neutral subfamily of cytokeratins [46] . In endothe- lial ...
181