Embryonic Stem Cell
Embryonic stem cell-derived cardiomyocytes for the treatment of doxorubicin-induced cardiomyopathy
... Mouse embryonic stem cell; OCT3/4: Octamer-binding transcription factor 3/4; PCR: Polymerase chain reaction; PSM: Peptide sequence match; QTc: Corrected QT; SSEA-1: Stage-specific embryonic ...
15
Human Embryonic Stem Cell (hESC) and Human Embryo Research
... created embryonic stem cell lines are needed to serve as a comparison with the newly developed lines to establish whether they are indeed equivalent to traditionally developed ...single cell ...
8
Human Embryonic Stem Cell (hESC) and Human Embryo Research
... created embryonic stem cell lines are needed to serve as a comparison with the newly developed lines to establish whether they are indeed equivalent to traditionally developed ...single cell ...
8
Realizing Potential: A Pragmatic Look at Human Embryonic Stem Cell Research
... n the United States, there are over 400,000 cryogenically frozen embryos (Hoffman, et al., 2003). These frozen embryos are almost exclusively produced from in vitro fertilization (IVF) and related treatments. Much debate ...
6
LongSAGE profiling of nine human embryonic stem cell lines
... human embryonic stem cell ...human embryonic stem ...between embryonic stem cells and terminally differentiated ...human embryonic stem cell ...in ...
12
Varicella-Zoster Virus Infects Human Embryonic Stem Cell-Derived Neurons and Neurospheres but Not Pluripotent Embryonic Stem Cells or Early Progenitors
... shown to be a cell-intrinsic inhibition of VZV replication (20, 27). Interestingly, naïve hESC have PML bodies with an atypical dis- tribution and composition (3), and it is possible that they have a role in the ...
8
Embryonic stem cell-derived extracellular vesicles enhance the therapeutic effect of mesenchymal stem cells
... MSCs have an signaficant effect on wound-healing and some other diseases [29, 30]. To investigate whether ES-EVs could enhance the therapeutic effects of MSCs in vivo, luciferase-labeled senescent MSCs were pre-treated ...
15
Role of CD133 in human embryonic stem cell proliferation and teratoma formation
... transport, cell division, cell proliferation, apop- tosis, and other processes ...the cell cycle were also consistent with changes in the S phase popula- tion of CD133 KO hESCs ...the cell ...
14
The Epigenomics of Embryonic Stem Cell Differentiation
... The PcG complex is not the only chromatin modifier that antagonizes Brg1. Mbd3, a subunit of the Nucleosome Remodeling Deacetylase (NuRD) complex co-occupies with Brg1 several hundred promoters associated with ...
11
MRAS GTPase is a novel stemness marker that impacts mouse embryonic stem cell plasticity and Xenopus embryonic cell fate
... lineage-specific cell types of the three germ layers (Lan et ...Xenopus embryonic cells has demonstrated a conserved function for a histone methyltransferase adaptor protein in smooth muscle cell ...
12
Embryonic stem cell research and the moral status of human embryos
... ES cell research is morally ...ES cell research are likely to outweigh the harms, including the harms created by destroying a given number of embryos with moral status, then we should do ES cell ...
5
Otx2 is an intrinsic determinant of the embryonic stem cell state and is required for transition to a stable epiblast stem cell condition
... pluripotent stem cells is essential for the comprehension of mammalian development and for the design of experimental protocols for the controlled generation of cell types of therapeutic interest (Hanna et ...
13
Identification of embryonic stem cell–derived midbrain dopaminergic neurons for engraftment
... promising cell source for future translational studies. The use of BAC transgenic reporter lines may not be suitable for human clini- cal translation due to the need for transgene insertion and reporter gene ...
13
A molecular scheme for improved characterization of human embryonic stem cell lines
... The lack of comparative analysis of hESC lines matters, because the properties and behavior of each line are uniquely shaped by their histories. It has become clear that different derivations produce hESC lines that are ...
13
Dissecting hematopoietic differentiation using the embryonic stem cell differentiation model
... an embryonic and fetal globin profile in ...as cell aggregation based emboli ...the embryonic HSC niche, efforts to identify the stromal components that support the main- tenance and differentiation ...
13
Human embryonic stem cell for the treatment of multiple sclerosis: A case report
... Introduction: Multiple sclerosis (MS) is a chronic demyelinating disease with inflammatory neurodegeneration. It is caused by the genesis of autoimmune response to self-antigens in a genetically susceptible individual. ...
5
Retrotransposons shape species specific embryonic stem cell gene expression
... KAP1 repression of retroviruses was initially discov- ered in the context of murine leukaemia virus (MLV) [55], which led on from original observations that MLV was restricted in embryonic cells [66] through its ...
12
Logical Fallacies in the Literature on Human Embryonic Stem Cell Research
... scientific. For a scientist, the decision is fairly simple. If the research is scientifically sound and is likely to yield beneficial results, then one must go forward with the project [. . . .] However, anti-abortion ...
17
Quantitative phosphoproteome analysis of embryonic stem cell differentiation toward blood
... To further delineate the hemangioblast population, a reporter ES cell line with the GFP coding sequences targeted into the Brachyury (Bry) locus was created by Fehling et al [3]. ES cells can differentiate in ...
16
Effect of substrate stiffness on early human embryonic stem cell differentiation
... on stem cell differentiation was provided by qualitative studies involving mouse mammary epithelial cells that showed increased differentiation when grown on soft gel colla- gen substrates as opposed to ...
8