Enabling Replicative Immortality: Telomeres and Telomerase
Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies
... human telomerase gene hTERT promoter mutations and mutations in genes involved in the alternative lengthening of telomeres pathway, such as ATRX and DAXX, has elucidated how these genomic changes contribute ...
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Telomeres and Telomerase: Molecular Views and Perspectives
... stabilization. Telomerase activity has been found to be high in almost all malignant cells which result in telomere dysfunc- tion and thus paves a molecular pathway towards the discovery of telomeres and ...
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Complex roles for telomeres and telomerase in breast carcinogenesis
... lack telomerase, the enzyme is upregulated in more than 90% of invasive breast ...before telomerase is reactivated during a critical transition from a telomerase- negative to a ...
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Telomerase Is Essential to Alleviate Pif1-Induced Replication Stress at Telomeres
... removing telomerase from chromosome ...that telomerase-deficient strains are also sensitive to PIF1 ...truncated telomeres that must be rapidly elongated by telomerase to maintain ...
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The role of telomeres and telomerase in hematologic malignancies and hematopoietic stem cell transplantation
... of telomerase. Significantly shortened telomeres, activation of telomerase, and altered expression of telomere-associated proteins are common features of various hematologic malignancies and are ...
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Telomeres and telomerase and their functional applications in myeloproliferative neoplasms and acute myeloid leukemia
... 1.1.6 Telomeres and telomerase in in human diseases Telomere dysfunction have been shown to play a role in many different diseases, from depression 43 to rheumatoid arthritis 44 , but telomere biology has ...
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RAD50 and RAD51 Define Two Pathways That Collaborate to Maintain Telomeres in the Absence of Telomerase
... by telomerase, yet recombina- tion can elongate telomeres in the absence of ...yeast telomerase RNA component, TLC1, is deleted, telomeres shorten and most cells ...short telomeres, ...
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Recombination Can either Help Maintain Very Short Telomeres or Generate Longer Telomeres in Yeast Cells with Weak Telomerase Activity
... of telomerase, the elongation of short, un- capped telomeres is dependent on ...short telomeres produced dif- ferent ...a telomerase deletion mutant ((27, 36, ...non-null telomerase ...
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Incorporation of Y′-Ty1 cDNA Destabilizes Telomeres in Saccharomyces cerevisiae Telomerase-Negative Mutants
... destabilize telomeres if telomeric Ty1 sequences recombine with Ty1 elements at other genomic loca- ...if telomeres harboring Y9-Ty1 retro- sequences are stable, we examined isolates of telomerase- ...
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Telomeres and telomerase in head and neck squamous cell carcinoma: from pathogenesis to clinical implications
... of telomerase and chaperone protein hsp90, an essential step for telome- rase holoprotein integrity and enzymatic activity [ 163 ...As telomerase expression is found in a large fraction of HNSCC, a subgroup ...
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Investigation of Telomerase/Telomeres system in Bone Marrow Mesenchymal Stem Cells derived from IPF and RA-UIP
... Short telomeres are expected to compromise the replicative potential of progenitor cells that remain in tissues after ...that telomeres from patients with IPF and RA-UIP are able to maintain ...
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PinX1 suppresses tumorigenesis by negatively regulating telomerase/telomeres in colorectal carcinoma cells and is a promising molecular marker for patient prognosis
... of telomerase/telomeres may be therefore a useful anticancer therapeutic ...intrinsic telomerase inhibitor and a puta- tive tumor suppressor through its binding to and inhibition of ...by ...
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Telomeres and Telomerase in the Aging Heart
... product-derived telomerase activator, on metabolic markers and cardiovascular ...that telomerase activation is a rejuvenation strategy for age-associated diseases such as cardiovascular diseases and might ...
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Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes.
... B4, TRFs reached their shortest length of 3.5 kbp by pd 100 and thereafter were stable. It is intriguing that the limited decrease in cell viability occurred in B4 cells between pd 70 an[r] ...
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Long telomeres and cancer risk: the price of cellular immortality
... the telomerase reverse transcriptase (TERT), but through differential effects on telomere ...lengthen telomeres as being strongly associated with cancer ...of telomeres in cancer etiology and ...
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Regulation of replicative immortality by GABPβ1L in TERT promoter mutant glioblastoma
... cells, telomeres are indefinitely maintained through the use of the enzymatic complex ...achieve replicative immortality and form a tumor, cancer cells must find a way to replenish telomeres ...
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Telomeres and Diseases Related to Telomeres
... mice telomeres occur at 100 times faster than humans which may be the reason for the shorter life span in mice ...that telomerase deficient mice age at a faster ...
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NobelMedicinePrize2009 Telomeres
... Shrinking telomeres and ageing cells Now it was time to start dissecting the telomere’s role in the life of a ...made telomeres gradually ...Tetrahymena telomerase RNA and observed similar ...
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Telomeres in cancer and aging
... abstract: Telomeres are unique structures at the ends of the chromosomes crucial for genetic stability of the ...cell. Telomeres shorten in the process of DNA replication due to inability of the DNA ...
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Telomeres and Oxidative Stress
... called telomerase. There are several factors that can shorten the telomeres which include telomere attrition during cell division, deficiency of Rad 54, which is involved in DNA repair and the methylation ...
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