enantioselective synthesis
Enantioselective synthesis of chiral cyclopent 2 enones by nickel catalyzed desymmetrization of malonate esters
... the enantioselective synthesis of chiral cyclopent-2-enones by the nickel-catalyzed desymmetrizing arylative cyclization of alkynyl bis(2,2,2- trifluoroethyl) malonates with arylboronic ...
5
DESIGN AND SYNTHESIS OF NEW MOLECULES BASED ON THIOLACTOMYCIN AS POTENTIAL ANTITUBERCULAR, ANTIMALARIAL AGENTS AND ENANTIOSELECTIVE SYNTHESIS OF (3R,4R), (3S,4S)- DIHYDROXYPYRROLIDINES
... and synthesis of new molecules based on thiolactomycin as potential antitubercular, antimalarial agents and enantioselective synthesis of (3R,4R), (3S,4S)-dihydroxypyrrolidines” has been undertaken ...
11
Catalytic enantioselective synthesis of α-chiral azaheteroaryl ethylamines by asymmetric protonation
... Abstract: The direct enantioselective synthesis of chiral azaheteroarylethylamines from vinyl aza-heterocycles and anilines is reported. A chiral phosphoric acid (CPA) catalyst promotes dearomatizing ...
5
A facile enantioselective synthesis of (R) massoialactone
... The enantioselective synthesis of naturally occurring bioactive compound (R) - Massoialactone has been successfully achieved employing Sharpless asymmetric epoxidation of allyl alcohol and selective hydride ...
5
Enantioselective synthesis of 2,3 disubstituted trans 2,3 dihydrobenzofurans using a Brønsted base/thiourea bifunctional catalyst
... catalytic enantioselective synthesis of trans- 2,3-disubstituted dihydrobenzofurans from readily-available salicylic aldehyde derivatives has been achieved using a bifunctional tertiary amine-thiourea ...
6
Enantioselective synthesis of 6,6 disubstituted pentafulvenes containing a chiral pendant hydroxy group
... Simple enantioselective synthesis of 6,6-disubstituted pentafulvenes bearing chiral pendant hydroxy groups are attained by cascade reactivity using commercially available proline-based ...
7
A Simple and Highly Efficient Enantioselective Synthesis of (S) Rivastigmine
... the enantioselective synthesis of (S)-Rivastigmine, a cho- linergic agent for the treatment of mild to moderate dementia of the Alzheimer’s type and dementia due to Parkinson’s disease, is accomplished by ...
7
Enantioselective synthesis of 3,5,6 substituted dihydropyranones and dihydropyridinones using isothiourea mediated catalysis
... Electron-rich aromatic substituents such as 4-MeOC 6 H 4 and 4- Me 2 NC 6 H 4 are tolerated and desired products 23 and 24 are af- forded in good yields of 76 % and 71 % with excellent 95 % and 94 % ee, respectively. ...
7
Recent advances in ω-transaminase-mediated biocatalysis for the enantioselective synthesis of chiral amines
... Abstract: Chiral amines are important components of 40–45% of small molecule pharmaceuticals and many other industrially important fine chemicals and agrochemicals. Recent advances in synthetic applications of ω ...
26
Recent advances in ω-transaminase-mediated biocatalysis for the enantioselective synthesis of chiral amines
... Transaminases (TAs) are one of the largest groups of enzymes used in the synthesis of chiral amine building blocks [10-13]. As TAs play key roles in various cellular signaling and metabolic pathways, their ...
31
Versatile C(sp2)−C(sp3) ligand couplings of sulfoxides for the enantioselective synthesis of diarylalkanes
... To elucidate the retention of stereochemistry exhibited by ligand coupling reactions, we set about the synthesis of enantiomerically pure sulfoxides 3ac-3ae (Scheme 7). Erbium(III)- catalysed alkylation of 2 ...
7
Enantioselective synthesis of non-proteinogenic 2-arylallyl-α-amino acids via Pd/In catalytic cascades
... efficient synthesis of both R- and S- enantiomers of 2-arylallyl-α-amino acids via a diastereoselective Pd/In mediated catalytic allylation of chiral N-sulfinyl-α-imino esters is ...
17
Enantioselective synthesis of β fluoro β aryl α amino pentenamides by organocatalytic [2,3] sigmatropic rearrangement
... catalytic enantioselective [2,3]-sigmatropic rearrangement of quaternary ammonium salts bearing a (Z)-3-fluoro-3-arylprop-2-ene group generates, after addition of benzylamine, a range of β-fluoro-β-aryl-α-amino ...
5
Enantioselective synthesis of (S) 1 Boc 3 hydroxypiperidine using enzymes and whole cell biocatalysts
... Applications of enzymatic biocatalysis and whole cell biotransformations have had a great impetusfor the production of pharmaceutical key intermediates. Enzymes offer many competitive advantages over conventional ...
6
ENANTIOSELECTIVE SYNTHESIS OF (–)-8,4ʹ-OXYNEOLIGNANS & SYNTHESIS AND BIOEVALUATION OF NITROGEN CONTAINING HETEROCYCLIC COMPOUNDS
... total synthesis of biologically important plant metabolites (–)-virolin, (–)-surinamensin, (–)-raphidecursinol B and (–)-polysphorin has been described using two common intermediates, beginning from readily ...
11
The chemoenzymatic and enantioselective synthesis of biologically active resorcylic acid lactones (RALs)
... In 2007 Winssinger et al. completed an enantioselective total synthesis of radicicol A (4) (Scheme 1.19). The preparation of this target commenced with the secondary alcohol (R)-(–)-4- penten-2-ol [(R)-25] ...
171
Enantioselective synthesis of allylboronates and allylic alcohols by copper catalyzed 1,6 boration
... concise synthesis of atorvastatin (13), the well-known cholesterol-lowering ...catalytic enantioselective 1,6-additions, are topics for future study in our ...
5
Quinidine Catalysed Enantioselective Synthesis of 6 and 4 Trifluoromethyl Substituted Dihydropyrans
... catalytic enantioselective formal [4+2] cycloaddition of allenoates with isomeric 1,1,1- trifluoro- and 4,4,4-trifluoromethylbutenones, allowing the preparation of stereodefined C(4)- and C(6)-trifluoromethyl ...
7
Enantioselective synthesis of (R) and (S) 2 methyl [3,3,2 2H3] alanines
... The reaction mixture was cooled to room te erature and a solution 3R, 6 R-2,5-Dimethoxy-3-benzyl-3,6of 6 g of potassium carbdnate in 2 5 m L of dirnethyl-3,6-dihydrupyrazine7a water adde[r] ...
7
Isothiourea catalysed enantioselective pyrrolizine synthesis : synthetic and computational studies
... catalytic enantioselective synthesis of a range of cis -pyrrolizine carboxylate derivatives with outstand- ing stereocontrol (14 examples, >95 : 5 dr, >98 : 2 er) through an isothiourea-catalyzed ...
9