enhanced permeability and retention effect
Nanomedicine for drug targeting: strategies beyond the enhanced permeability and retention effect
... Abstract: The growing research interest in nanomedicine for the treatment of cancer and inflammatory-related pathologies is yielding encouraging results. Unfortunately, enthusiasm is tempered by the limited specificity ...
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PASSIVE AND ACTIVE TUMOR TARGETING OF NANO CARRIERS FOR ANTI-CANCER DRUG DELIVERY- A REVIEWDaljeet Singh Manhas*DOWNLOAD/VIEW/http://doi.org/10.5281/zenodo.195190
... the Enhanced Permeability and Retention effect whereas ligands grafted at the surface of nanocarriers allow active targeting by binding to the receptors overexpressed by cancer cells or ...
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Enhancing anticancer effects, decreasing risks and solving practical problems facing 3-bromopyruvate in clinical oncology: 10 years of research experience
... of enhanced permeability and retention ...(abolish enhanced permeability and retention effect) sparing normal tissues, facilitate new delivery routes for 3BP (eg, topical ...
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Preparation, in vitro and in vivo evaluation of polymeric nanoparticles based on hyaluronic acid-poly(butyl cyanoacrylate) and D-alpha-tocopheryl polyethylene glycol 1000 succinate for tumor-targeted delivery of morin hydrate
... the enhanced permeability and retention effect (EPR) of TPGS, and actively through the binding of HA to the receptors overexpressed by cancer cells or angiogenic endothelial cells (as shown in ...
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Extracellular vesicle-based drug delivery systems for cancer treatment
... EPR effect: enhanced permeability and retention effect; EVs: extracellular vesicles; FasL: Fas ligand; GALA: synthetic peptide with a glutamic acid-alanine- leucine-alanine repeat; ...
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Delivery of polymeric nanostars for molecular imaging and endoradiotherapy through the enhanced permeability and retention (EPR) effect
... The high uptake in tumours with high EPR characteristics was confirmed by ex vivo biodistribution experiments, demonstrating a tumour accumulation of 14.8 ± 4.0 %ID/g after 3 days (Figure 3D). Considerably lower tumour ...
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<p>Modulation of Tumor Hypoxia by pH-Responsive Liposomes to Inhibit Mitochondrial Respiration for Enhancing Sonodynamic Therapy</p>
... activity enhanced the therapeutic effect of IR780-mediated ...the enhanced permeability and retention (EPR) effect, intrave- nous infusion of MI-PEOz-lip could effectively ...
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Be Active or Not: the Relative Contribution of Active and Passive Tumor Targeting of Nanomaterials
... through enhanced permeability and retention (EPR) ...EPR effect and the receptor-mediated targeting to NM accumulation in tumor tissues has not been clearly defined ...EPR effect with a ...
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Therapeutic properties of a vector carrying the HSV thymidine kinase and GM CSF genes and delivered as a complex with a cationic copolymer
... bystander effect that allows to destroy not only cells transfected with the gene but also nearby untransfected cells, thus strongly increasing the potential efficacy ...hanced permeability and ...
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Improving Conventional Enhanced Permeability and Retention (EPR) Effects; What Is the Appropriate Target?
... In recent work, selectively targeting tumor cells, researchers describe targeting the cancer cells via the GRP78 receptor using a GRP78-targeting peptide conjugated to a PEGylated gold nano-rod. When light was applied, ...
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Enhancing Customer Retention with Interpersonal Relationship Strategies in the Nigerian Deposit Money Banks
... customer retention as the marketing objective of preventing customers from going to the ...Customer retention is the way in which firms concentrate their efforts on existing customers with the aim to ...
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Effect of pasteurization on alcohol yield and ascorbic acid retention in orange wine
... Orange fruits are acidic fruit which contain healthy nutritional content that works wonders for the body. It acts as a fabulous source of vitamin c and a wide variety of essential nutrients required by the body. Fresh ...
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ENHANCED TRANSDERMAL PERMEABILITY OF DICLOFENAC DIETHYLAMINE USING NANOEMULSION VEHICLE
... Ethical clearance for the handling of experimental animals was obtained from the institutional animal ethical committee. Albino rabbits of either sex each weighing 1.5 to 2.0 kg and 24 months of age were used in this ...
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Liquid Crystalline Nanoparticles as an Ophthalmic Delivery System for Tetrandrine: Development, Characterization, and In Vitro and In Vivo Evaluation
... Pre-ocular retention was determined using a noninvasive fluorescence imaging ...apparent permeability coefficient of the optimal formulation was ...Pre-ocular retention capacity study indicated that ...
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Impact of monovalent cations on soil structure. Part II. Results of two Swiss soils
... water retention curves of the soils are presented in ...water retention (higher water content at any given matric suction) than si l due to the higher clay ...little effect on water retentions in ...
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<p>Enhanced transdermal permeability and drug deposition of rheumatoid arthritis via sinomenine hydrochloride-loaded antioxidant surface transethosome</p>
... rst-pass effect and gastro- intestinal-tract ...sustained-release effect, which is con- ducive to the long-term treatment of ...and permeability are greatly ...
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Enhanced permeability of blood–brain barrier and targeting function of brain via borneol-modified chemically solid lipid nanoparticle
... The SLN and two kinds of BO-SLN injected via tail vein were evaluated using in vivo imaging systems. Further, 15 Kunming mice (20 ± 2 g) were divided into five groups randomly, and free Cy7 solution, Cy7-loaded SLN, and ...
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Mechanics of rainfall infiltration through soil slope
... the permeability of the ...capillary effect which limits water’s downward movement and causes temporary water storage in the soil layers which may lead to pore-water pressure build-ups at the interfaces ...
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Combination of hydrotropic nicotinamide with nanoparticles for enhancing tacrolimus percutaneous delivery
... and permeability of FK506 and that 20% (w/v) NIC pre- sented higher FK506 permeability and was thus chosen as the hydrotropic solution to solubilize FK506 and prepare ...synergistic effect on FK506 ...
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Enhanced cellular uptake and long-term retention of chitosan-modified iron-oxide nanoparticles for MRI-based cell tracking
... In conclusion, chitosan–USPIO NPs offer an efficient approach for magnetic labeling of cells, enabling cellular MRI-based tracking at the single-cell scale in vitro and potentially also in vivo over extended periods of ...
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