Epidermal Growth Factor Receptor(EGFR)
Original Article Relationship between epidermal growth factor receptor (EGFR) mutation and serum cyclooxygenase-2 Level, and the synergistic effect of celecoxib and gefitinib on EGFR expression in non-small cell lung cancer cells
... Abstract: Epidermal growth factor receptor (EGFR) mutations occur mostly in patients with lung adenocarcinoma; such patients are also more likely to express cyclooxygenase-2 (COX-2), ...
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Tamoxifen may prevent both ER+ and ER breast cancers and select for ER carcinogenesis: an alternative hypothesis
... which epidermal growth factor receptor (EGFR) and/or Her2 mitogenic signaling is ...Moreover, EGFR over-expression and Her2 amplification are both correlated with ER negativity ...
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Metaplastic breast carcinomas exhibit EGFR, but not HER2, gene amplification and overexpression: immunohistochemical and chromogenic in situ hybridization analysis
... the epidermal growth factor receptor ...Human epidermal growth factor receptor (HER)2 and EGFR have attracted much attention in the medical literature over ...
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Potential Role of Preoperative Conventional MRI Including Diffusion Measurements in Assessing Epidermal Growth Factor Receptor Gene Amplification Status in Patients with Glioblastoma
... MATERIALS AND METHODS: We analyzed pretreatment MR imaging scans from 147 consecutive patients with newly diagnosed glioblas- toma and correlated MR imaging features with tumor epidermal growth ...
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E5 Protein of Human Papillomavirus Type 16 Protects Human Foreskin Keratinocytes from UV B-Irradiation-Induced Apoptosis
... the epidermal growth factor receptor (EGFR) (42); increases the ligand-dependent activation of the EGFR in HaCaT cells, an HPV-negative human keratinocyte cell line (23), and in ...
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Upregulation of EGFR signaling is correlated with tumor stroma remodeling and tumor recurrence in FGFR1 driven breast cancer
... fibroblast growth factor receptor (FGFR)1-driven breast ...of receptor tyrosine kinases, resulted in an altered collagen-enriched stroma observed both during tumor dormancy and ...ylated ...
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Expression of the epidermal growth factor receptor (EGFR) and the phosphorylated EGFR in invasive breast carcinomas
... Immunohistochemical staining for EGFR and pEGFR was per- formed on 4 μm thick formalin-fixed paraffin sections, after overnight heating at 37°C. Subsequent deparaffinization, rehy- dration and antigen retrieval ...
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Vasculogenic mimicry is associated with trastuzumab resistance of HER2 positive breast cancer
... human epidermal growth factor receptor (HER)-2 is called HER2-positive (HER2+) breast ...a receptor tyrosine kinase that has no specific ligands; the protein is activated when it forms ...
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Hepatitis C virus NS5A protein blocks epidermal growth factor receptor degradation via a proline motif- dependent interaction
... Antibodies and Western blotting. The polyclonal sheep anti-NS5A serum has been described previously (Macdonald et al., 2003). Other antibodies were purchased from the following sources: HA antibody from Sigma; ...
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Breast cancer oestrogen independence mediated by BCAR1 or BCAR3 genes is transmitted through mechanisms distinct from the oestrogen receptor signalling pathway or the epidermal growth factor receptor signalling pathway
... Furthermore, growth of BCAR1 and BCAR3 transfectants (which are fully responsive to oestrogen; Table 3 and Additional file 1) was not stimulated by anti- oestrogen [17,18], suggesting that there is no role for ERα ...
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A study of Expression of Epidermal growth factor receptor (EGFR) in Lung Cancers.
... emphasizes on screening procedure. Monoclonal antibodies is one of the screening method which can be followed. Our recent research topic of interest has been the identification of monoclonal antibodies and their staining ...
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Y box binding protein 1 serine 102 is a downstream target of p90 ribosomal S6 kinase in basal like breast cancer cells
... translation factor that is overexpressed in a number of cancer types, including breast cancer [1,2], prostate cancer [3], bone cancer [4], lung cancer [5,6], colon cancer [7], muscle cancer [8] and, most recently, ...
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ER and PR signaling nodes during mammary gland development
... its receptor (receptor activator of NF-κB) in the mammary epithelium is sufficient to induce side branching in virgin mammary Figure ...estrogen receptor (ER) alpha/ progesterone receptor ...
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Integration of endocrine therapy with targeted agents
... oestrogen receptor (ER)-positive breast cancer ...peptide growth factor mediated mitogenic signalling pathways, which may or may not crosstalk with existing ER-signalling ...human epidermal ...
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Redefining prognostic factors for breast cancer: YB 1 is a stronger predictor of relapse and disease specific survival than estrogen receptor or HER 2 across all tumor subtypes
... human epidermal growth factor receptor (HER)-2 is a marker of poor prognosis in breast can- cer, following its initial report in 1987 by Slamon and cowork- ers ...this receptor such as ...
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Molecular biology of breast cancer metastasis Inflammatory breast cancer: clinical syndrome and molecular determinants
... estrogen receptor (ER) and progesterone receptor (PgR) expression has been corre- lated with a shorter disease-free survival time and overall poor clinical outcome of breast cancer patients, including those ...
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CT Imaging Correlates of Genomic Expression for Oral Cavity Squamous Cell Carcinoma
... late with necrosis, primary tumor size, or lymph node metastases was not supported. No significant correlations were found for cyclin D protein, VEGF ligand C, or VEGF receptor 3. However, a trend was observed ...
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Synthesis, characterization and molecular docking studies of anilinoquinazoline derivatives
... Whereas when compared to EGFR, newly synthesized ligands bind as similar to reference ligand (gefitinib) (Barbosa et al., 2014). PR-6 form hydrogen bond (C-N) with Lys745 and Asp800, C-O-O with Ser995 backbone (Fig ...
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The therapeutic target of estrogen receptor alpha36 in estrogen dependent tumors
... within EGFR/Src/Shc complex during estrogen signaling ...up-regulated EGFR expression, while down-regulated ER-α66 expression in MCF7 ...the growth switch of breast tumors after acquired tamoxifen ...
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The role of reversible ubiquitylation in EGF signalling
... We devised an assay to look for mobilization of DUBs with EGF stimulation, using a GFP tagged DUB library transiently expressed in HeLa cells. The assay was viable and the redistribution of USP8 could be observed, ...
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