Epidermal Growth factor Receptor Status.
Epidermal Growth factor Receptor Status in Gastric Malignancies
... Within only a few years, anticancer therapeutic development against advanced cancers has moved from almost a standstill, with a paucity of new agents showing potential for major effect, to the rapid development of agents ...
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The epidermal growth factor receptor family in breast cancer
... association between HER-2 expression and reduced DFS (P = 0.033) and cancer-specifi c survival (P = 0.042). HER-4 expression was correlated with a longer DFS (P = 0.049) and cancer-specifi c survival (P = 0.044). ...
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Role of lapatinib in the first-line treatment of patients with metastatic breast cancer
... of epidermal growth factor receptor (EGFR/ErbB1) and human epidermal growth factor receptor 2 ...HER2 status, and lack of large prospective phase III trials ...
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The coexpression and prognostic significance of c-MET, fibroblast growth factor receptor 2, and human epidermal growth factor receptor 2 in resected gastric cancer: a retrospective study
... coexpression status of c-MET, fibroblast growth factor receptor 2 (FGFR2), and human epidermal growth factor receptor 2 (HER2) in human GC and their clinical ...
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Conversion of epidermal growth factor receptor 2 and hormone receptor expression in breast cancer metastases to the brain
... HER2 status in brain metastases was less prone to changes compared with HRs, and conversions in both directions were more ...only factor increasing the HER2 conversion ...
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Impact of tumor biomarkers and patient’s age on the “disease stage” in women with breast cancer in Erbil city
... prognostic factor; however, this issue is now considered ...hormone receptor negative or HER2 receptor positive, and is more likely to present at an advanced stage, either because of its biological ...
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Implications of post-pneumonectomy compensatory lung growth in pulmonary physiology and disease
... lung growth and a concurrent increase in growth factors and/or nutrient ...lung growth in a manner similar to the left cranial lobe where blood flow remained ...lung growth indicate that the ...
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Epidermal Growth Factor Receptor PI3K Signaling Controls Cofilin Activity To Facilitate Herpes Simplex Virus 1 Entry into Neuronal Cells
... 3 Receptor tyrosine kinases and PI3K are involved in cofilin ...Active receptor tyrosine kinases are recruited to the cell membrane at 4°C and dispersed upon virus ...
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Triple-negative breast cancer: new perspectives for targeted therapies
... limited binding affinity for other vascular endothelial growth factor-receptor (VEGFR) ligands, VEGF-B, and VEGF-C. Newer antiangiogenic agents bind to VEGFR-2 and thus prevent all ligand binding to ...
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New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management
... Long years of basic and clinical research have resulted in a switch from this repetitious iatrogenic intoxication of patients and their tumors to more targeted antineo- plastic “snipers”, which eliminate tumor cell ...
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Metastasizing Maxillary Ameloblastoma: Report of a Case with Molecular Characterization
... human epidermal growth factor receptor belonging to the same family of EGFR and its protein overexpression has been found in several carcinomas ...
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Liver-derived human mesenchymal stem cells: a novel therapeutic source for liver diseases
... c-met receptor and the downstream effectors, ERK1/2, p38, MAPK, and PI3K/Akt, while long-term exposure resulted in cytoskeletal rearrangement, cell migration, and marked in- hibition of ...
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<p>Targeting the MET-Signaling Pathway in Non-Small–Cell Lung Cancer: Evidence to Date</p>
... In the absence of mutation, the introns adjacent to METex14 in the premessenger RNA (pre-mRNA) are spliced, which gives rise to an mRNA containing METex14 that becomes the functional MET receptor. METex14 codes ...
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6100.pdf
... EGFR(epidermal growth factor receptor) and the related HER-2 (human epidermal growth factor receptor 2) associated with breast cancer has allowed for the ...
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Molecularly Targeted Therapies for Malignant Gliomas
... MGs often show increased RAS activ- ity (cell growth and differentiation) be- cause of mutation or amplification of up- stream growth factor receptors (39). Farnesyltransferases are part of the RAS ...
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When ubiquitination meets phosphorylation: a systems biology perspective of EGFR/MAPK signalling
... A recurring theme in the interplay between phosphoryl- ation and ubiquitination is that phosphorylation often in- fluences the ubiquitination and thus degradation of the modified protein, such as in the case of c-Myc ...
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Skin Targeting Approaches in Cosmetics
... Neverthless, some agents that stimulate collagen pro- duction can also be served as targets for enhancing collagen production in the skin. In the past, topical application of soluble animal collagen was used in an ...
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Relationship between epithelial-to-mesenchymal transition and the inflammatory microenvironment of hepatocellular carcinoma
... important factor involved in the occurrence and development of tumors [29, ...its receptor IL-6R, which consists of two polypeptide chains; a ligand-binding chain (GP80) and a signal con- duction chain ...
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Vasculogenic mimicry is associated with trastuzumab resistance of HER2 positive breast cancer
... transforming growth factor (TGF)-β and its receptor induces Tzm resistance mediated by the nuclear translocation of SMAD2/3 molecules through in- duction of the epithelial-mesenchymal transition ...
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The progress of targeted therapy in advanced gastric cancer
... Approximately one million people are diagnosed each year with gastric cancer, making it the fourth most com- mon cancer and the second leading cause of cancer re- lated death worldwide with an estimated 800,000 deaths ...
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