Epigenetics and MicroRNA
Genomics, microRNA, epigenetics, and proteomics for future diagnosis, treatment and monitoring response in upper GI cancers
... genomics, microRNA, epigenetics and proteomics with a focus on upper gastrointestinal cancers are considered herein to allow for an understanding of where these technologies stand with respect to cancer ...
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Role of epigenetics-microRNA axis in drug resistance of multiple myeloma
... Despite administration of novel therapies, multiple myeloma (MM) remains incurable with resistance to drugs leading to relapse in most patients. Thus, it is critical to understand the detailed mechanisms underlying the ...
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Epigenetics of amphetamine-induced sensitization: HDAC5 expression and microRNA in neural remodeling
... Results: Naïve C57black6 mice that experience acute exposure to amphetamine (4 mg/kg, by injection intraperitoneally) show expression of both total and phosphorylated (S259) HDAC5 antige[r] ...
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Role of Epigenetics in Uveal Melanoma
... of epigenetics is beginning to unfold an era of contemporary approaches to reducing the risk and improving the clinical treatment of ...including microRNA expression, hypermethylation of genes and histone ...
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Epigenetics mechanisms and degenerative diseases
... [2]. Epigenetics thus involves the mecha- nisms which establish and transmit different patterns of gene expression within all types of cells irrespective of identical DNA ...
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On the epigenetics of vascular regulation and disease
... of RNA-induced silencing complex (RISC) and as siSC (scrambled inhibitory RNA) respectively [1,37] miRNAs are synthesized by RNA polymerase II as a long RNA primary transcript (pri-miRNA) and cleaved by Drosha, the ...
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Epigenetics and imprinting in human disease
... a microRNA, miR-675, has been identified within the first exon of ...this microRNA demonstrates distinct expression patterns from H19 and is speculated to play a role in placental and postnatal growth ...
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Methylmercury Epigenetics
... and epigenetics has rapidly expanded in the past ...effects microRNA (miRNA) expression, histone modifications, and DNA methylation both globally and at individual ...
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Translating epigenetics into clinic: focus on lupus
... The dysregulation of miRNAs in SLE is a combination of internal and external factors. miRNAs play central roles in different stages of cellular activity, as well as contribute extensively to multifaceted aspects of lupus ...
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Epigenetics and Proteomics Join Transcriptomics in the Quest for Tuberculosis Biomarkers
... ABSTRACT An estimated one-third of the world’s population is currently latently infected with Mycobacterium tuberculosis. Latent M. tuberculosis infection (LTBI) progresses into active tuberculosis (TB) disease in ~5 to ...
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Cancer and epigenetics interrelationship in prevention and cure
... Whereas the production of p50 is an ongoing (“constitutive”) process, p52 production is a tightly controlled process regulated by its gene, NFKB2. In theory, any epigenetic factor which could inhibit or diminish the ...
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Metabolic recoding of epigenetics in cancer
... cancer epigenetics Glutamine metabolism also contributes to the produc- tion of acetyl-CoA and α-KG, and glutamine oxidation correlates with the cell state-specific epigenetic land- ...
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Epigenetics and Primary Care
... by epigenetics, but a small subset of genes are subject to regulation by an epigenetic phenome- non called imprinting, in which areas of DNA methylation differentially affect the paternal and maternal chromosomes ...
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Epigenetics and obesity: the devil is in the details
... 18. Fraga MF, Ballestar E, Paz MF, Ropero S, Setien F, Ballestar ML, Heine- Suner D, Cigudosa JC, Urioste M, Benitez J, Boix-Chornet M, Sanchez- Aguilera A, Ling C, Carlsson E, Poulsen P, Vaag A, Stephan Z, Spector TD, ...
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Epigenetics, Behaviour, and Health
... genes and could bring about a change in gene function without changing the gene sequence, are called epigenetic changes here. The dynamic nature of epigenetic regula- tion in contrast to the static nature of the gene ...
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Epigenetics in cancer therapy and nanomedicine
... Promising clinical data on a number of malignancies, including chronic leukemia and colorectal, ovarian, lung, and breast cancer, are robustly demonstrating that epigenetic therapy has t[r] ...
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Epigenetics of chronic inflammatory diseases
... gene approaches and epigenome-wide association studies (EWAS) have reported links between atherosclerosis and differentially methylated DNA at specific gene loci (eg, LINE, ALU, CETP, LPL, FOXP3, ESR1, and MCT3). This is ...
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Epigenetics in the pathogenesis of rheumatoid arthritis
... for epigenetics, it is broadly defined as the study of heritable changes in gene activity that do not involve any alterations in the primary DNA sequence ...[9]. Epigenetics originally focused on DNA ...
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Epigenetics and airways disease
... Epigenetics is the term used to describe heritable changes in gene expression that are not coded in the DNA sequence itself but by post-translational modifications in DNA and histone proteins. These modifications ...
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Air pollution, epigenetics, and asthma
... Exposure to traffic-related air pollution (TRAP) has been implicated in asthma development, persistence, and exacer- bation. This exposure is highly significant as large segments of the global population resides in zones ...
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