ERK1/2 signaling
The Progression in the Mouse Skin Carcinogenesis Model Correlates With ERK1/2 Signaling
... effector ERK1/2. Phosphory- lated ERK1/2 showed a progressive increase from the papilloma to the squamous and spindle cell lines implying that ERK1/2 signaling is involved ...
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Original Article MicroRNA-155 modulates the expression of pro-inflammatory cytokines in natural killer cells of rats exposed to chronic mild stress by regulation of ERK1/2 signaling pathway
... sible signaling pathway mechanism, we deter- mined the expression levels of p-ERK1/2 and ...that ERK1/2 signaling is an important player in neu- ral plasticity and neurogenesis ...
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TGF-β1 stimulates migration of type II endometrial cancer cells by down-regulating PTEN via activation of SMAD and ERK1/2 signaling pathways
... activated ERK1/2 signaling is essential for the invasive phenotype in different types of human cancer [26, 29, ...of ERK1/2 signaling could block the tumor-promoting roles of ...
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Rapamycin Reduced Ischemic Brain Damage in Diabetic Animals Is Associated with Suppressions of mTOR and ERK1/2 Signaling
... phosphorylated ERK1/2 were increased in the cerebral cortex after ischemic injury, which is consistent to our previous reports ...that ERK1/2 is highly expressed in diabetes-recruited damage ...
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Nonmyocyte ERK1/2 signaling contributes to load-induced cardiomyopathy in Marfan mice
... for ERK1/2 signaling in load-induced heart failure in Marfan mice, given that specific antagonism with a MEKi prevented all perturbations of myocardial architecture and ...excessive ...
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Baicalein increases the expression and reciprocal interplay of RUNX3 and FOXO3a through crosstalk of AMPKα and MEK/ERK1/2 signaling pathways in human non-small cell lung cancer cells
... intracellular signaling pathways, baicalein could protect mice from metabolic syndrome induced by a high-fat diet ...inactivation ERK1/2 signaling was involved in the induction of FOXO3a and ...
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Mediating ERK1/2 signaling rescues congenital heart defects in a mouse model of Noonan syndrome
... Reduction of ERK1/2 hyperphos- phorylation inhibits enhanced cardiomyocyte proliferation. (A and B) Ki-67 immunostaining (E16.5; original magnification, ×20). Ki-67–positive cardio- myocytes are abundant in ...
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C5a2 can modulate ERK1/2 signaling in macrophages via heteromer formation with C5a1 and beta-arrestin recruitment
... Testing ERK1/2 activation of HMDM in the presence of a C5a2 neutralizing antibody did significantly increase ERK1/2 activation at C5a concentrations below those required to up-regulate ...
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KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling
... dephosphorylates ERK1/2 in NSCLC cells. KDM2A activated ERK1/2 through epigenetic repression of DUSP3 expression via demethylation of dimethylated H3K36 at the DUSP3 ...activating ...
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PTPRF as a novel tumor suppressor through deactivation of ERK1/2 signaling in gastric adenocarcinoma
... The 5-year OS rate of our entire cohort was 60.09% (Figure 2A). The effect of each clinicopathological charac- teristic was also evaluated by Kaplan–Meier survival curves (Figure 2B and H). With univariate regression ...
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Dopamine and GABA Interaction in Basal Ganglia: GABA A or GABA B Receptor Stimulation Attenuates L DOPA Induced Striatal and Nigral ERK1/2 Signaling in a Rat Model of Parkinson’s Disease
... the ERK1/ 2 pathway regulation [7], have been attributed to PD- associated D1 ...phospho- ERK1/2 activation has been linked to the severity of dy- skinesias, a motor side effect of long-term ...
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Redox-sensitive MAPK and Notch3 regulate fibroblast differentiation and activation: a dual role of ERK1/2
... activate ERK1/2, contributing to lung injury and ...of ERK1/2 likely potentiates the progression of ...mice, ERK1/2 signaling remains unaffected, if not inhibited, at ...
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Targeting ERK1/2-bim signaling cascades by BH3-mimetic ABT-737 as an alternative therapeutic strategy for oral cancer
... MAPK signaling cascades, ERK1/2 is considered an attractive target for developing therapeutics against cancers due to its significant pharmacological specificity and selectivity ...the ...
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Inhibition of extracellular signal-regulated kinase 1/2 signaling has beneficial effects on skeletal muscle in a mouse model of Emery-Dreifuss muscular dystrophy caused by lamin A/C gene mutation
... Figure 2 Increased ERK1/2 activity in skeletal muscle of Lmna H222P/H222P ...phosphorylated ERK1/2 (p-ERK1/2) and total ERK1/2 in protein extracts from ...
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Modeling the signaling endosome hypothesis: Why a drive to the nucleus is better than a (random) walk
... which Erk1/2 signaling endosomes exhibited greater efficiency than diffusing Erk1/2 molecules ...phosphorylated Erk1/2 with the retrograde transport velocity of ...
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Original Article FRS2 promotes the progression of non-small cell lung cancer
... mediated signaling pathways. Dysfunction of FGFR signaling was associated with cancer progression and was shown to affect cancer origination, angiogene- sis, and metastasis of multiple cancer ...FGFR ...
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Elevated dual specificity protein phosphatase 4 in cardiomyopathy caused by lamin A/C gene mutation is primarily ERK1/2-dependent and its depletion improves cardiac function and survival
... that ERK1/2 signaling is the primary driver of Dusp4 expression without relying on pharmacological inhibitors, we assessed its expression in hearts of Lmna H222P/H222P mice that were interbred with ...
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CircRNA_104889 promotes lung adenocarcinoma cell invasion via sponging miR4458
... the ERK1/2 pathway is an important signal transduc- tion pathway involving in various cellular activities and diseases ...inhibit ERK1/2 signaling and epithelial growth factor recep- ...
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Dopamine D1 receptor-mediated activation of the ERK signaling pathway is involved in the osteogenic differentiation of bone mesenchymal stem cells
... of ERK1/2 on hBMSCs was significantly increased after SKF-38393 treat- ment ...the ERK1/2 signaling pathway and upreg- ulated Runx2 transcriptional activity in hBMSCs, which fur- ther ...
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Original Article Salidroside induces apoptosis via ERK1/2 in human leukemia K562 cells
... of ERK1/2 was also ...of ERK1/2 signaling pathway in human leukemia K562 cells and may be a promising candidate for leukemia ...
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