Estrogen receptor binding protein
Delineation of a unique protein-protein interaction site on the surface of the estrogen receptor
... cognate binding surface on ER␣ represents an important control site that is involved in regulating receptor activity under certain ...of protein-protein interactions have been isolated from ...
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Effects of selective estrogen receptor agonists on estrogen receptor expression in the uterus of ovariectomized rats
... Selective estrogen receptor agonists were shown to affect PR expression in the uterus differently ...ERα protein expressions are up regulated in parallel by ...ERβ binding mediates down ...
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Beta protein 1 homeoprotein induces cell growth and estrogen- independent tumorigenesis by binding to the estrogen receptor in breast cancer
... Beta Protein 1(BP1), an isoform of DLX4, belongs to the homeobox family of genes, master regulatory genes implicated in early development and cell differentiation that are frequently deregulated in cancer [1, ...
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Vitamin D and gonadal steroid resistant New World primate cells express an intracellular protein which competes with the estrogen receptor for binding to the estrogen response element
... consensus estrogen response element (ERE) 5 9 -CTAGAAAGTCAGGTCACAGTGACCT-GAT- CAAT-3 9 ; 5 9 ERE half-site-type 1 (5 9 EREhs1) 5 9 -CTAGAAAGT- CAGGTCACAGGAT-CAAT-3 9 ; 5 9 ERE half-site-type 2 (5 9 EREhs2) 5 9 ...
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Molecular conservation of estrogen-response associated with cell cycle regulation, hormonal carcinogenesis and cancer in zebrafish and human cancer cell lines
... of estrogen carcinogenicity is the multiple estrogen-receptor signal-transduction path- ways associated with increased cell proliferation and inhibition of apoptosis ...of estrogen ...
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WNT4 mediates estrogen receptor signaling and endocrine resistance in invasive lobular carcinoma cell lines
... fluorescent protein; ER: Estrogen receptor; ERBS: Estrogen receptor binding site; ERE: Estrogen response element; FGFR: Fibroblast growth factor receptor; HER2: ...
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Estrogen receptor transcription and transactivation Structure function relationship in DNA and ligand binding domains of estrogen receptors
... ligand binding and ...progesterone receptor (PR) [20 • ...hormone binding by the PR [21], GR [22] and androgen receptor ...core protein contacting helices H8, H9 and ...
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Estrogen receptor transcription and transactivation Estrogen receptor alpha and estrogen receptor beta: regulation by selective estrogen receptor modulators and importance in breast cancer
... the estrogen receptor regulates transcription Although the DNA binding domains of ERα and ERβ are nearly identical, there is considerable documentation that these receptor subtypes differ ...
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pRb controls Estrogen Receptor alpha protein stability and activity
... pRb protein plays an important role as an adaptor in the regulation of ESR1 stability and functionality, a key player in hormonal ...DNA binding domain (C) and the hinge region ...includes ...
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Centromere protein A, an essential centromere protein, is a prognostic marker for relapse in estrogen receptor positive breast cancer
... [GEO:GSE7390]. To evaluate the ability of CENP-A to predict response to tamoxifen, we used a dataset of 276 patients from the Institut Jules Bordet (JBI) [10,20,21]. Expression data are available at the GEO database ...
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Novel drugs that target the estrogen-related receptor alpha: their therapeutic potential in breast cancer
... shock protein 90 (90), heat shock protein 70 (70), and cyclophilin 40 (40), from the receptor, which undergoes conformational structural changes and ...dimerized estrogen receptor ...
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Immunophenotypes of Glycogen Rich Clear Cell Carcinoma
... The three cases revealed three different immuno-pheno- types (Table 4). Case 1 showed positivity for ER and negativ- ity for PR. Case 2 was positive for PR, but negative for ER. Case 3 presented with triple negative ...
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Farnesyl transferase inhibitor R115,777 enhances tamoxifen inhibition of MCF 7 cell growth through estrogen receptor dependent and independent pathways
... Results Combinations of the specific FTI R115,777 with either ICI182,780 or PBPE exhibit a synergistic effect on MCF-7 cell growth inhibition, while its combination with Tam is additive, as previously reported for ...
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Estrogen receptor transcription and transactivation Estrogen receptor knockout mice: what their phenotypes reveal about mechanisms of estrogen action
... Clinical as well as experimental data imply a role for estro- gen as well as other endocrine factors in maintaining bone mass. For example, menopause or castration increases the rate of osteoporosis progression in women ...
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ER-α36: a novel biomarker and potential therapeutic target in breast cancer
... Notes: (A) Transcription of eR-α36 initiates from a previously unidentified promoter in the first intron of ER-α66. We labeled the first exon of ER-α36 as “1” to distinguish it. Besides, eR-α36 has an extra, unique ...
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Drug and Vaccine Design against Novel Coronavirus (2019-nCoV) Spike Protein through Computational Approach
... spike protein sequences were collected from a protein database and analysed with various bioinformatics tools to identify suitable natural inhibitors for the N-terminal receptor binding domain ...
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The Genome of Swinepox Virus
... ) receptor, IFN resistance protein, interleukin-18 binding protein, IFN- ␣ /  binding protein, extracellular enveloped virus host range protein, dUTPase, hydrox- ysteroid ...
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Effects of estrogen on circulating "free" and total 1,25 dihydroxyvitamin D and on the parathyroid vitamin D axis in postmenopausal women
... D-binding protein (DBP). Estrogen increased fasting total calcitriol from ...D-binding protein increased from 348 +/- 16 to 428 +/- ...
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Shabani, Naim (2008): Prognostische Signifikanz der Expression von Estrogenrezeptor alpha (ER-α) und beta (ER-β), Progesteronrezeptor A (PR-A) und B (PR-B) in Endometriumkarzinomen. Dissertation, LMU München: Medizinische Fakultät
... exprimiert Estrogen- (ER) und Progesteronrezeptoren (PR), welche in Zusammenhang mit endokrinen, autokrinen und parakrinen Prozessen stehen und auf die Hormone Estrogen und Progesteron ...
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Progesterone receptors animal models and cell signaling in breast cancer: Role of steroid receptor coactivators and corepressors of progesterone receptors in breast cancer
... ligand binding, in vitro studies using a reconstituted progesterone-responsive transcription system in mammalian cells revealed that PR-A and PR-B are not functionally ...both receptor isoforms has been ...
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