Estrogen Receptor Positive
Estrogen receptor positive breast cancers and their association with environmental factors
... to estrogen, not all breast cancers are responsive to this hormone and its ...to estrogen depends on whether they have estrogen recep- ...their estrogen receptor status (estrogen ...
8
Molecular portraits and trastuzumab responsiveness of estrogen receptor-positive, progesterone receptor-positive, and HER2-positive breast cancer
... To provide deeper insight into the biological nature of TPBCs, we investigated the genomic landscape of HER2-positive breast cancers according to ER and PR status using the TCGA data. Whole-exome sequencing data ...
11
Upregulation of HSF1 in estrogen receptor positive breast cancer
... HSF1 is a key transcription factor in the regulation of cellular homeostasis and modulates protein folding, stability, and protein-protein interactions. In response to a variety of stresses, HSF1 binds to the promoter ...
7
A Therapeutic Target for Hormone-independent Estrogen Receptor-positive Breast Cancers
... specifically estrogen (E2) and proges- terone, is the basis of antihormone therapy for breast cancer patients ...trogen receptor (ER), which are hormone-activated transcription ...suppresses ...
9
microRNA Regulation in Estrogen Receptor-Positive Breast Cancer and Endocrine Therapy
... The inhibition of known oncomiRs, such as miR-21, has also provided a promising strategy to suppress ER + breast carcinogenesis and enhance the effects of tamoxifen and other anti-estrogen treatments. Recently, Yu ...
19
FGFR1 underlies obesity-associated progression of estrogen receptor–positive breast cancer after estrogen deprivation
... The negative health effects of obesity extend to every organ system and include elevated risk and worse prognosis for most cancers. Breast cancer is the most frequently diagnosed cancer in women and is the second leading ...
18
Role of estrogen receptors and Src signaling in mechanisms of bone metastasis by estrogen receptor positive breast cancers
... Results: The clinical results showed that ER ≥ 1% breast cancers showed a positive correlation with bone metastasis, which was found to be the preferred site of metastasis. An in vivo bone metastasis was ...
11
Cholesterol biosynthesis pathway as a novel mechanism of resistance to estrogen deprivation in estrogen receptor positive breast cancer
... Recent findings have suggested that cholesterol metab- olites, such as 27-HC, can act as endogenous ligands for ER [45–47]. In order to investigate this further, we assessed the effect of 25-HC and 27-HC on ER-mediated ...
14
Characterization and prognosis of estrogen receptor positive/progesterone receptor negative male breast cancer: a population based study
... The median age at diagnosis of MBC is 65 – 69 years old [3, 6, 23 – 25] in the West counties and a little bit younger in Asia [26] and the Middle East [27]. Most lit- erature has validated the prognostic role of age at ...
8
Paralemmin-1 is over-expressed in estrogen-receptor positive breast cancers
... Our discovery of paralemmin-1 overexpression in breast cancer cell lines came from a cDNA array com- parison between the ER-positive breast cancer cell line, MCF-7, and its tamoxifen-selected, ER-negative deriva- ...
10
A pilot study of the immunogenicity of a 9-peptide breast cancer vaccine plus poly-ICLC in early stage breast cancer
... A current challenge in immunotherapy for breast cancer is how to break immune tolerance, which is especially challenging in estrogen receptor positive disease types. One approach is the use of ...
10
Local estrogen axis in the human bone microenvironment regulates estrogen receptor positive breast cancer cells
... Estrogen receptor-alpha (ER-α), which mediates the action of estradiol in fueling the development and progression of breast cancer, is expressed in approximately 70% of all ma- lignant breast tumors, making ...
16
Expression and in vitro assessment of tumorigenicity for NOD1 and NOD2 receptors in breast cancer cell lines
... of estrogen receptor-positive and estrogen receptor-negative breast cancer cell ...an estrogen receptor-positive cellu- lar model, acting through the blockage of ...
7
Oxidative stress and breast cancer biomarkers : the case of the cytochrome P450 2E1
... The estrogen receptor positive MCF-7 and the triple negative MDA- MB-231 breast cancer cells were used as experimental system to estimate ROS generation in these cells overexpressing CYP2E1 and ...
10
Sensitivity Evaluation of Two Human Breast Cancer Cell Lines to Tamoxifen through Apoptosis Induction
... in estrogen receptor-positive (ER- positive MCF-7) and estrogen receptor-negative (ER-negative MDA-MB-231) human breast cancer cell lines in vitro in order to determine if these ...
9
Comparative study of ER status in premenopausal and postmenopausal women with carcinoma breast
... The decision of whether to use adjuvant tamoxifen for patients with DCIS should be made on an individual basis. The use of tamoxifen has been associated with vasomotor symptoms, deep vein thrombosis, pulmonary embolism ...
105
Estrogen receptor transcription and transactivation Estrogen receptor knockout mice: what their phenotypes reveal about mechanisms of estrogen action
... mammals. Estrogen is primarily known for its role in the development and functioning of the female reproductive ...for estrogen in male fertility, bone, the circulatory system and immune system have been ...
8
Farnesyl transferase inhibitor R115,777 enhances tamoxifen inhibition of MCF 7 cell growth through estrogen receptor dependent and independent pathways
... ER positive breast tumours, we have previously shown that the association of Tam with FTI-277 led to an additive increase in its antipro- liferative effects on MCF-7 cells ...ER positive breast tumour cell ...
9
Controllable drug uptake and nongenomic response through estrogen-anchored cyclodextrin drug complex
... demonstrated that estrone and tamoxifen competed with CDE 1 -Ada-DOX for membrane estrogen receptor binding in MCF-7 cells. Intermolecular self-assembly of CDE 1 molecules were observed, showing ...
14
Tamoxifen may prevent both ER+ and ER breast cancers and select for ER carcinogenesis: an alternative hypothesis
... The data from the BCPT and MORE prevention trials are shown in Table 2. In 1992, the NSABP began the P-01 BCPT to determine if tamoxifen, an antagonist to estrogen in breast tissue, was effective for breast cancer ...
6