Estrogen Receptor β
The Role of Estrogen Receptor β in Prostate Cancer
... In the adult human prostate, ERβ is characterized as an important mediator of epithelial differentiation (37). The mechanisms through which ERβ main- tain differentiation involve the degrada- tion of hypoxia-inducible ...
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Impact of Genetic Variants in Estrogen Receptor-β Gene in the Etiology of Uterine Leiomyomas
... The LD analysis of five SNPs revealed no link- age disequilibrium in either controls or patient subjects. A study by Fischer et al. (2010) in ER-β gene (rs2987983, rs3020450 and rs3020449) pro- moter polymorphisms ...
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Prenylation inhibitors stimulate both estrogen receptor α transcriptional activity through AF 1 and AF 2 and estrogen receptor β transcriptional activity
... Immunocytochemical analysis of the effects of prenyltransferase inhibitors on estrogen receptor (ER) α distribution in MCF-7 cells. (a) Cells, deprived of estradiol (E2) for 7 days, were treated or not with ...
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Suppression of the inflammatory response in experimental arthritis is mediated via estrogen receptor α but not estrogen receptor β
... Figure 2 ERA-63 inhibits the tetanus-specific delayed type hyper- sensitivity response in WT and ERβKO but not in the ERαKO mice. Mice were ovariectomized at day -14. Mice (n = 8 per group) were oral- ly treated daily ...
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Estrogen receptor β protects against acoustic trauma in mice
... The hormone estradiol affects the auditory system both by itself and by its interaction with neuroprotective factors. In this study, we examined the role of estrogen receptors (ERs) in response to auditory trauma. ...
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Linking estrogen receptor β expression with inflammatory bowel disease activity
... of estrogen receptor (ER)β expression in peripheral blood T lymphocytes from CD/UC patients with active disease (n = 27) as compared to those in remission (n = 21) and healthy controls (n = ...
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Prenatal levonorgestrel exposure induces autism-like behavior in offspring through ERβ suppression in the amygdala
... ER β (estrogen receptor β ) and its target genes in the amygdala with autism-like behavior in male offspring, while there is a much smaller effect on female ...ER β suppression is due ...
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Mutation detection in human estrogen receptor ? gene in infertile male patients by denaturing high-performance liquid chromatography
... Background: For screening sequence variations in genes, rapid turnover time is of fundamental importance. While, many of the current methods are unfortunately time consuming and technically difficult to implement. ...
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ERβ regulation of NF- B activation in prostate cancer is mediated by HIF-1
... by estrogen receptor β (ERβ) based on the inverse correlation between p65 and ERβ expression that exists in prostate carcinomas and reports that ERβ can inhibit NF-κB activation, although the ...
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Cholesterol biosynthesis inhibitor RO 48-8071 suppresses growth of hormone-dependent and castration-resistant prostate cancer cells
... androgen receptor or antihormone therapy (chemical castration); however, drug-resistant cancer cells generally emerge during treatment, limiting the continued use of systemic ...androgen receptor protein ...
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Estrogens and male reproduction
... At the same time, the development of a line of transgenic male mice lacking estrogen receptor (x, estrogen receptor I~ or aromatase gene provided further evidence [r] ...
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The Role of Estrogen Receptor-a and Estrogen Receptor-b in the Hyperluteinized Mouse Ovary
... The studies in Chapter 2 demonstrate that immature a ERKO females are able to ovulate when administered exogenous gonadotropins yet the oocyte yield is reduced compared to age-matched wild-type females, despite the ...
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Ospemifene for the treatment of dyspareunia associated with vulvar and vaginal atrophy: potential benefits in bone and breast
... equine estrogen therapy reported in the Women’s Health Initiative trial, the same risks of stroke, cardiovascular events, breast cancer, and venous thromboembolism may still exist for the BZA/CE ...
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Characterization and prognosis of estrogen receptor positive/progesterone receptor negative male breast cancer: a population based study
... for estrogen receptor (ER) and progesterone receptor (PR) markers has been recommended for all newly diagnosed breast cancer patients by the College of American Pathologists and American Society of ...
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Chinese herb mix Tiáo Gēng Tāng possesses antiaging and antioxidative effects and upregulates expression of estrogen receptors alpha and beta in ovariectomized rats
... controversial [29-32]. In our study, expression of ERs decreased in the hypothalamus of ovariectomized rats and increased upon treatment with TG-decoction. Simi- lar results have been recently reported by Wu et al. [33] ...
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Does Metformin affect ER, PR, IGF-1R, β-catenin and PAX-2 expression in women with diabetes mellitus and endometrial cancer?
... phase, estrogen binding to ER receptor acts as a transcription factor triggering local IGF-1 production ...[29]. Estrogen not only influences IGF-1 production but also takes part in the regulation of ...
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Estrogen-related receptor β deficiency alters body composition and response to restraint stress
... hormone receptor 2 (Crhr2) — as well as one gene associated with whole-body energy balance and stress responses, Cholecystokinin B receptor (Cckbr) ...
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Shabani, Naim (2008): Prognostische Signifikanz der Expression von Estrogenrezeptor alpha (ER-α) und beta (ER-β), Progesteronrezeptor A (PR-A) und B (PR-B) in Endometriumkarzinomen. Dissertation, LMU München: Medizinische Fakultät
... Es ist seit mehreren Jahren bekannt, dass das Endometriumkarzinom häufig bei Frauen vorkommt, die unter einer Langzeiteinnahme von Estrogenen ohne Gestagenschutz stehen. 6,7 Typische Risikofaktoren, die die Entwicklung ...
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A pilot study of the immunogenicity of a 9-peptide breast cancer vaccine plus poly-ICLC in early stage breast cancer
... in estrogen receptor positive patients was shown to be feasible and ...the estrogen receptor posi- tive patients were able to generate T cells response to pep- tide ...
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The Transactivating Function 2 (AF 2) of Estrogen Receptor (ER) α Is Indispensable for ERα Mediated Physiological Responses and AF 1 Activity
... the estrogen receptor (ER) is a key regulator of those ...several estrogen-mediated physiological responses in the AF2ERKI ...discern estrogen physiological functions which involve ...
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