Estrogen-related receptor alpha
Novel drugs that target the estrogen-related receptor alpha: their therapeutic potential in breast cancer
... considered. Estrogen-related receptor alpha has attracted attention as a therapeutic target in triple-negative breast cancers with de novo resistance to, and in breast cancers with acquired ...
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Estrogen related receptor alpha in castration-resistant prostate cancer cells promotes tumor progression in bone
... as estrogen receptors (ERs), and a large number of so-called orphan receptors for which no ligand has yet been determined ...[12]. Estrogen receptor-related receptor alpha (ERRα) ...
16
Anti-tumor effect of estrogen-related receptor alpha knockdown on uterine endometrial cancer
... We next performed loss of function experiments using siRNAs and assessed cell proliferation. Recent studies reported that ERRs are involved in cell proliferation in several cancer cells. However, little information is ...
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Key regulator of cellular metabolism, estrogen-related receptor α, a new therapeutic target in endocrine-related gynecological tumor
... protein), alpha subunit [HADHA], ferrochela- tase [FECH], AMP-activated protein kinase [AMPK] signal- ing [including acetyl-CoA carboxylase 2 [ACC2], ATP-AMP transphosphorylase 2 [AK2], and carnitine ...
9
Novel endocrine therapeutic strategy in endometrial carcinoma targeting estrogen-related receptor α by XCT790 and siRNA
... Table 1). According to the results, there were four TFs whose P-values were below 0.05 including three upregulated TFs and one downregulated TF. Transcription factor EB (TFEB) was the only downregulated TF induced by ERR ...
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<p>ERRα is an aggressive factor in lung adenocarcinoma indicating poor prognostic outcomes</p>
... an estrogen-related receptor alpha inverse agonist, thus inducing production of mitochondrial reactive oxygen species and inhibiting the growth of lung cancer cells ...
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The role of estrogen receptor alpha in mediating chemoresistance in breast cancer cells
... the estrogen antagonist tamoxifen and the chemothera- peutic agents did not have good therapeutic effects in breast cancer ...although related studies have been performed by others ...
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Original Article Expression of PGRMC1 in paraffin-embedded tissues of breast cancer
... progesterone receptor membrane component 1 (PGRMC1) expression may explain this ...of estrogen receptor alpha (ERα), progestrone receptor (PR), Ki67 and PGRMC1 by immunohistochemistry ...
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Original Article Estrogen receptor alpha gene polymorphisms contribute to fragility fracture susceptibility in elderly postmenopausal women with heart failure
... The most extensively studied variants of the ESR1 gene are the PvuII and XbaI polymor- phisms, which have been linked to a lower sen- sitivity to estrogen [45, 46]. Because of the important effects of estrogens on ...
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Role of Estrogen Receptor-Alpha in an Experimental Model of Bronchial Asthma
... Serum estrogen level. Serum estrogen level was measured by chemiluminescence ELISA. The assay system utilizes one anti-estrogen antibody for solid phase (microtiter wells) immobilization and another ...
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Clinicopathological Correlation of Estrogen Receptor Alpha Gene Polymorphism and Estrogen Receptor Status in Breast Cancer - A Study.
... Ionizing radiation is has increased risk of breast cancer.Information on radiation and breast cancer risks has come mainly from epidemiological studies of atomic bomb survivors or women exposed to radiation for ...
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The origins of estrogen receptor alpha positive and estrogen receptor alpha negative human breast cancer
... classical estrogen-induced mitogenic ...to estrogen [19–21], including estrogen-induced growth, they continued to express ER, suggesting that these pathways may only be partially involved in the ...
6
Tamoxifen may prevent both ER+ and ER breast cancers and select for ER carcinogenesis: an alternative hypothesis
... Tamoxifen resistance has also been shown to emerge from a subpopulation in which epidermal growth factor receptor (EGFR) and/or Her2 mitogenic signaling is hyperactived. Transfection and activation of these ...
6
Targeting estrogen/estrogen receptor alpha enhances Bacillus Calmette-Guérin efficacy in bladder cancer
... mediating estrogen effects in various tissues [19-22], and could play important roles in BCa progression ...that estrogen could down-regulate NF-κB mediated IL-6 expression in human BCa lines [28], and IL-6 ...
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Estrogen alpha receptor antagonists for the treatment of breast cancer: a review
... potential. Molecular docking of the most active synthe- sized resveratrol analogs a and b was performed in estro- gen receptor alpha protein cavity to observe their binding pattern as shown in Fig. 16. The ...
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pRb controls Estrogen Receptor alpha protein stability and activity
... hormone receptor and PPARgamma-dependent transcription ...androgen receptor in a hormone-independent manner (Lu and Danielsen jbc 1998) [12] and can regulate its activity via the E2F transcription factor 1 ...
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Cohesin is required for expression of the estrogen receptor-alpha ( ESR1 ) gene
... the estrogen-induced expression of ER α target ...the estrogen-regulated genes CXCL12, GREB1, PGR, and PKIB were normalized to 28S ribosomal mRNA, graphed relative to the control sample and expressed as ...
13
The role of total and cartilage specific estrogen receptor alpha expression for the ameliorating effect of estrogen treatment on arthritis
... [22]. Estrogen affects T lympho- poiesis, and we and others have previously demonstrated that estrogenic repression of T lymphopoiesis is mediated via ERα ...[27,34]. Estrogen has also been shown to ...
11
BMPR2 expression is suppressed by signaling through the estrogen receptor
... Quantitative analysis of BMPR2 transcripts by cultured lymphocytes and PMVECs was performed using real- time RT-PCR, as previously described [18]. Briefly, cDNA was synthesized from 1 μ g of total cellular RNA using ...
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Breast related effects of selective estrogen receptor modulators and tissue selective estrogen complexes
... The breast safety profile of CE/BZA has been evaluated in murine and primate models [30,99]. In a study com- paring estradiol, CE, and BZA, BZA blocked the estro- genic effects of CE or estradiol on ductal length, ...
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