eukaryotic translation initiation factor 4E
Identification in the Ancient Protist Giardia lamblia of Two Eukaryotic Translation Initiation Factor 4E Homologues with Distinctive Functions
... fide initiation factor performing the function of a scaffold in the translation initiation complex of ...in translation initiation in Giardia (unpublished data), whereas ...
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MEK inhibition drives anti-viral defence in RV but not RSV challenged human airway epithelial cells through AKT/p70S6K/4E-BP1 signalling
... 4E-BP1: Eukaryotic translation initiation factor 4E-binding protein 1; AECs: Airway epithelial cells; AKT: Protein kinase B; CPE: Cytopathic effect; EC50: Half maximal effective ...
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Taking aim at translation for tumor therapy
... mRNA translation rates are frequently observed in human ...protein eukaryotic translation initiation factor 4E (eIF4E), leading to enhanced translation of numerous ...
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Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model
... As eukaryotic translation initiation factor 4E (eIF4E) cooperates with c-Myc during lymphomagenesis, induces drug resistance, and is a genetic modifier of the rapamycin response, we ...
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Eukaryotic initiation factor 4E 3 is essential for meiotic chromosome segregation, cytokinesis and male fertility in Drosophila
... As translation is mainly controlled at the initiation step, different mechanisms have evolved to regulate eIF4E activity (Hernández et ...and 4E-HP (Cho et ...global translation ...
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Binding Specificities and Potential Roles of Isoforms of Eukaryotic Initiation Factor 4E in Leishmania
... basal translation factor, since in higher eukaryotes, the majority of the eIF4E is found in the postribosomal supernatant and in 48S ...distinct factor for stabilizing the interaction between the ...
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Visualization of the Interaction between the Precursors of VPg, the Viral Protein Linked to the Genome of Turnip Mosaic Virus, and the Translation Eukaryotic Initiation Factor iso 4E In Planta
... the translation eukaryotic initiation factor iso 4E ...the translation factor might be needed for two different functions, depending of the VPg precursor involved in the ...
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Differential regulation of protein synthesis in skeletal muscle and liver of neonatal pigs by leucine through an mTORC1-dependent pathway
... and eukaryotic initiation factor (eIF) 4E-binding protein-1 (4E-BP1) phosphorylation in gastrocnemius and masseter muscles (P < ...and 4E-BP1 phosphorylation were completely ...
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Original Article Expression of eukaryotic initiation factor 4E and 4E binding protein 1 in colorectal carcinogenesis
... eIF4E, 4E-BP1 and their phosphorylated forms simul- taneously in the same normal, dysplastic and malignant colorectal ...dependant translation of potent growth pro- moting proteins and oncogenic proteins, ...
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The Lymphocytic Choriomeningitis Virus RING Protein Z Associates with Eukaryotic Initiation Factor 4E and Selectively Represses Translation in a RING-Dependent Manner
... cell translation factor, eukaryotic initiation factor 4E (eIF-4E) in infected and transfected ...this translation factor led us to investigate whether Z ...
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Interaction of eukaryotic initiation factor eIF-4B with a picornavirus internal translation initiation site.
... stimulate translation (2, 44), a 72-kDa protein from RRL, and a 70-kDa protein found in both HeLa cell extract and RRL ...independent translation initiation have not yet been well es- tablished, and ...
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Suppression of eukaryotic initiation factor 4E prevents chemotherapy-induced alopecia
... target translation [25,39-41]. Given that suppressing translation initiation appears a promising approach for cancer therapy, by using small molecule inhibitors of eIF4A or eIF4E:eIF4G interaction or ...
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Complex Formation between Potyvirus VPg and Translation Eukaryotic Initiation Factor 4E Correlates with Virus Infectivity
... various initiation factor isomers and the identification of the binding domain in a highly conserved region of the VPg are indications that the interac- tion plays an important role in the viral life ...the ...
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Ribosomal RACK1 promotes chemoresistance and growth in human hepatocellular carcinoma
... Coordinated translation initiation is coupled with cell cycle progression and cell growth, whereas excessive ribo- some biogenesis and translation initiation often lead to tumor transformation ...
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Avian Reovirus Nonstructural Protein p17-Induced G2/M Cell Cycle Arrest and Host Cellular Protein Translation Shutoff Involve Activation of p53-Dependent Pathways
... large initiation factor eIF4G, an interaction that is inhibited by association of eIF4E with the small 4E-binding proteins ...karyotic translation initiation factor 2 ␣ (eIF2 ␣ ) ...
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Original Article Knockdown of eukaryotic translation initiation factor 3 subunit B inhibits cell proliferation and migration and promotes apoptosis by downregulating WNT signaling pathway in acute myeloid leukemia
... tion, the high expression of CTNNB1 impairs bone marrow hematopoiesis and is related to the elevated self-renewing ability of leukemic cells in AML [13]. Regarding these findings, we propose that EIF3B might regulate the ...
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<p>eIF2α promotes vascular remodeling via autophagy in monocrotaline-induced pulmonary arterial hypertension rats</p>
... of eukaryotic translation initiation factor 2, which is a key protein that catalyzes the initiation of protein ...the translation initiation factor family, plays a ...
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eIF5B increases ASAP1 expression to promote HCC proliferation and invasion
... independent early recurrence factor after primary resection in patients with HCC [19]. Then, the 220 patients with HCC were divided into 2 groups based on their overall eIF5B expression level: a high eIF5B ...
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Potential of human PON2 as an anti pseudomonal therapy
... tobramycin. Treatment with 2 MIC tobramycin completely killed pre-exponential but not mid-exponential cultures within 24 hours. This was not unexpected as growth rates are known to influence susceptibility to ...
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Revisiting an old acquaintance: role for eIF5A in diabetes
... the translation of native rabbit globin mRNA (5), which actually argued against a role for eIF5A as an initiation factor in vivo, its activity in the methionyl- puromycin assay led to this protein ...
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