Exploring amine and thiol Michael Addition
Exploration of Thiol-Michael Addition Bioconjugation to Extend Polymers of a Protein-Based Hydrogel
... The Michael-addition reactions were between the cysteine thiol of our protomers and the Michael acceptors already bioconjugated to PEG (VS-PEG-VS and Mal-PEG- ...
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Dual functional materials via CCTP and selective orthogonal thiol Michael addition/epoxide ring opening reactions
... The scope for post polymerisation functionalisation has proven to be fruitful for epoxide containing polymers, and many combinations of polymerisations and functionalisations remain unexplored. The focus for this current ...
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Protected sulphonate nanoparticles, thiol Michael functionalisation of nanogel decorated nanoparticles, and thiol Michael microcapsules for agricultural mobility and adhesion applications
... Interfacial thiol-Michael addition capsules The capusles were allowed to dry out on a microslope slide while being monitored using a light microscope with a 20x magnification ...unreacted ...
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Asymmetric Michael addition using sugar derived organocatalysts
... Highly enantio-and diastereoselective Michael addition of cyclohexanone to nitroolefins catalyzed by a chiral glucose-based bifunctional secondary amine-. thiourea catalyst[r] ...
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Amine Nucleophilic Addition to Nitro-alkene as a New Reaction Mode for the Synthesis of N-heterocycles
... Xiaodong Michael Shi who offered his endless and energetic advice, encouragement and undertook tremendous responsibility in supervising me for the completion of my research and ...
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Nucleophilic thiol-yne addition chemistry for the synthesis of tuneable and cytocompatible poly(ethylene glycol) hydrogel materials
... the thiol-yne and amino-yne reactions, these polymerisation reactions result in high molecular weight polymers in high ...However, exploring this reaction is still in its early stages but this initial study ...
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Aza-Michael mono-addition using acidic alumina under solventless conditions
... main Michael acceptor used to study the activity of the ...allyl amine and propargyl amine (entries 5 and 6) gave good to excellent results, showing that negative inductive effects are short ranged ...
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Solvent-free, catalyst-free Michael-type addition of amines to electron-deficient alkenes
... RR1NH + Scheme 1 Results and Discussion The experimental procedure is very simple. A mixture of amine and α,β-unsaturated compound was stirred at room temperature without any solvent and catalyst. The product was ...
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‘Claycop’ catalyzed highly efficient and chemoselective aza Michael addition under solvent free condition
... General Procedure for the aza-Michael reaction using claycop: A mixture of amine (1 mmol), α,β-unsaturated ester (1.1 mmol) and ‘claycop’(10 mol%) was stirred at room temperature for the stipulated time ...
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Isothiourea mediated organocatalytic Michael addition lactonization on a surface : modification of SAMs on silicon oxide substrates
... tertiary amine and readily available, bench-stable precursors at the carboxylic acid oxidation ...intermolecular Michael lactonization of arylacetic acids and tri fl uoromethyl- enones in the presence of ...
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Michael addition of thiols to α,β-unsaturated carbonyl compounds under solvent-free conditions
... In a model reaction, methyl vinyl ketone was taken as a representative α,β-unsaturated carbonyl compound; this was treated with an equimolar amount of thiophenol in the absence of a catalyst under neat conditions at room ...
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Isothiourea catalysed enantioselective Michael addition of N heterocyclic pronucleophiles to α,β unsaturated aryl esters
... enantioselective Michael addition of 3-aryloxindole and 4-substituted- dihydropyrazol-3-one pronucleophiles to a,b-unsaturated p -nitrophenyl esters is ...tertiary amine Lewis bases, in which the ...
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Synthesis of Bridged Tetrahydrobenzo[b]azepines and Derivatives through an Aza-Piancatelli Cyclization/Michael Addition Sequence
... unprotected amine 3ha in 89% yield upon treatment with thiophenol and potassium ...free amine 9 starting from ...hand, amine 9 could be directly obtained from 3ar by a simple hydrogenation ...
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‘Grafting to’ of RAFTed responsive polymers to glass substrates by thiol ene and critical comparison to thiol gold coupling
... To enable “ grafting to ” a reactive end-group is required that can undergo an e ffi cient and preferably orthogonal coupling reaction. Various functional groups have been employed for this, such as active esters, ...
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Design, synthesis and antimicrobial evaluation of pyrimidin-2-ol/thiol/amine analogues
... Sangeeta Narwal, Sanjiv Kumar and Prabhakar Kumar Verma * Abstract Background: Pyrimidine is an aromatic heterocyclic moiety containing nitrogen atom at 1st and 3rd positions and play an important role to forms the ...
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Organocatalysts: A powerful tool for asymmetric Michael addition
... Enantioselective Michael addition of car- bonyl compounds to nitroalkenes has been of great interest due to its imperturbable approach for the synthesis of synthetically useful γ-nitro carbonyl ...conjugate ...
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Synthesis and Characterization of 5- Amino-1, 3, 4-Thiadiazole-2-thiol and its Amine Group Derivatives
... 2. Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq. *Corresponding Author: Mustafa M. Shihab Abstract This work includes preparation of 5-Amino-1,3,4-thiadiazole-2-thiol from ...
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Synthesis of (-) cytisine using a 6 endo aza Michael addition
... proceeded excellently using di-iso-propylazodicarboxylate, separation of the product from the diacylhydrazine by-product was difficult and tedious. We, therefore, found it to be more practical to employ ...
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Stereoselective intramolecular Michael addition reactions of pyrrole and their application to natural product syntheses
... Many of these colleagues have been good friends as well as people to socialise with, and even occasionally climb rocks with. In particular, I would like to thank Dr. Regan J. Thomson (formerly a PhD student of Prof. Lew ...
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Calcium Chloride catalyzed Intramolecular Oxa Michael addition of 2’-Hydroxychalcone to Flavanone
... Flavanones are generally prepared from the cyclization of 2’-hydroxychalcone using intramlecular OxaMichael addition. The regents used for this cyclization are Methane sulphonic acid [12], amino acid [13], ...
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