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Extracellular matrix (ECM) hydrogels

Extracellular matrix hydrogels from decellularized tissues: structure and function

Extracellular matrix hydrogels from decellularized tissues: structure and function

... other ECM proteins are known to contribute to collagen polymerization: fibronectin is known to organize collagen fibers, and minor collagens (collagen V and XI) are nucleation sites that must be present for ...

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Extracellular matrix derived hydrogels for dental stem cell delivery

Extracellular matrix derived hydrogels for dental stem cell delivery

... decellularised bone, dentine and spinal cord have been used as a 3D culture system for apical papilla stem cells... High cell viability Figure 6 was observed in bECMh, scECMh and dECMh, [r] ...

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The effect of mechanical cues on the chondrogenic differentiation of bone marrow derived mesenchymal stem cells

The effect of mechanical cues on the chondrogenic differentiation of bone marrow derived mesenchymal stem cells

... "Chondrogenic differentiation of bovine bone marrow mesenchymal stem cells MSCs in different hydrogels: influence of collagen type 11 extracellular matrix on MSC chondrogenesis." Biotech[r] ...

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Bioresponsive Hydrogels: Chemical Strategies and Perspectives in Tissue Engineering

Bioresponsive Hydrogels: Chemical Strategies and Perspectives in Tissue Engineering

... Bioresponsive hydrogels are dynamic systems that are capable of responding to or stimulating specific signals through the natural biological ...applications. Hydrogels are cross-linked 3D networks ...

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Silk fibroin/cartilage extracellular matrix scaffolds with sequential delivery of TGF-β3 for chondrogenic differentiation of adipose-derived stem cells

Silk fibroin/cartilage extracellular matrix scaffolds with sequential delivery of TGF-β3 for chondrogenic differentiation of adipose-derived stem cells

... The aim of this study was to fabricate biomimetic S/D scaffolds with a controlled release system to mimic an ideal 3-D microenvironment of chondrogenesis in vitro. We first fabricated composite scaffolds with SF and ...

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Ramipril inhibits AGE-RAGE-induced matrix metalloproteinase-2 activation in experimental diabetic nephropathy

Ramipril inhibits AGE-RAGE-induced matrix metalloproteinase-2 activation in experimental diabetic nephropathy

... Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases comprising more than 20 members that can degrade numerous types of ECM components [16]. Among various MMPs, MMP-2 has attracted ...

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Keystone symposium: The role of microenvironment in tumor induction and progression, Banff, Canada, 5–10 February 2005

Keystone symposium: The role of microenvironment in tumor induction and progression, Banff, Canada, 5–10 February 2005

... MMPs have long been of interest to cancer biologists for their ability to degrade components of the ECM and to shed cell surface ligands. Lynn Matrisian (Vanderbilt University School of Medicine, Nashville) ...

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Can hybrid hyaluronic acid represent a valid approach to treat rizoarthrosis? A retrospective comparative study

Can hybrid hyaluronic acid represent a valid approach to treat rizoarthrosis? A retrospective comparative study

... component matrix (ECM), reduces cartilage loss and chondrocytes apoptosis and decreases inflam- matory ...stimulating ECM production was due to the low MW component and that the rheological ...

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Transforming growth factor-β and abdominal aortic aneurysms

Transforming growth factor-β and abdominal aortic aneurysms

... Elastic fibres in the ECM of vascular tissues provide elasticity and resilience. Elastin is cross-linked and extremely hydrophobic, which makes it one of the most stable proteins in the body [80, 81]. Inflammatory ...

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Tumor-derived extracellular vesicles: reliable tools for Cancer diagnosis and clinical applications

Tumor-derived extracellular vesicles: reliable tools for Cancer diagnosis and clinical applications

... In support, it has been reported that the interrupting of nSMAse2 activity blocks exosomes secretion [54]. Besides, exosomal packaging of miRNAs is regulated through a sequence-dependent mechanism and mediated by ...

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Umbilical cord/placenta-derived mesenchymal stem cells inhibit fibrogenic activation in human intestinal myofibroblasts via inhibition of myocardin-related transcription factor A

Umbilical cord/placenta-derived mesenchymal stem cells inhibit fibrogenic activation in human intestinal myofibroblasts via inhibition of myocardin-related transcription factor A

... In the immunostaining of α-SMA, compared with the well-organized, intensely stained stress fibers in the HIMFs stimulated with TGF- β 1, the cells co-treated with CCG-100602 exhibited less organized stress fibers with ...

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The aggrecanopathies; an evolving phenotypic spectrum of human genetic skeletal diseases

The aggrecanopathies; an evolving phenotypic spectrum of human genetic skeletal diseases

... exon 5 [27] that arose on an agouti background and is homozygous perinatal lethal. Mutant pups have abnor- mal tracheal cartilage and so respiratory failure occurs soon after birth. Other phenotypic features include dis- ...

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Adipose derived mesenchymal stem cells from the sand rat: transforming growth factor beta and 3D co culture with human disc cells stimulate proteoglycan and collagen type I rich extracellular matrix

Adipose derived mesenchymal stem cells from the sand rat: transforming growth factor beta and 3D co culture with human disc cells stimulate proteoglycan and collagen type I rich extracellular matrix

... Stimulation of annulus cells by AD-MSC potentially offers a practical approach to autologous disc regeneration and repair. Lu et al. used micromass co-culture to show nucleus pulposus cells could secret soluble factors ...

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2018_Loeser.pdf

2018_Loeser.pdf

... Here, we adapt our previously published work to generate a paper-based Transwell assay. Paper scaffolds are advantageous for Transwell type applications because it eliminates the need for the inserts, introducing ...

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Spatial presentation of tissue specific extracellular matrix components and growth factors on porous electrospun fibre scaffolds for bone ligament interface tissue engineering

Spatial presentation of tissue specific extracellular matrix components and growth factors on porous electrospun fibre scaffolds for bone ligament interface tissue engineering

... Scaffolds produced by electrospinning of biodegradable fibres are particularly attractive for tissue engineering (TE) strategies as they provide high surface area and tailorable fibre diameter and alignment (Yang et al., ...

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Characteristic Expression of Extracellular Matrix in Subcutaneous Adipose Tissue Development and Adipogenesis; Comparison with Visceral Adipose Tissue

Characteristic Expression of Extracellular Matrix in Subcutaneous Adipose Tissue Development and Adipogenesis; Comparison with Visceral Adipose Tissue

... major ECM molecules, minor collagens including proteoglycan-related molecules (Col 15, 16, and 18) were expressed in adipose ...minor ECM and FN1 in adipose tissue has to be con- ...

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Exosome-mediated communication in the tumor microenvironment contributes to hepatocellular carcinoma development and progression

Exosome-mediated communication in the tumor microenvironment contributes to hepatocellular carcinoma development and progression

... The tumor microenvironment (TME) is an essential intrinsic portion of hepatocellular carcinoma (HCC) for the regulation of its origination, development, invasion, and metastasis. As emerging components of the tumor-host ...

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Changes in extracellular matrix (ECM) and ECM-associated proteins in the metastatic progression of prostate cancer

Changes in extracellular matrix (ECM) and ECM-associated proteins in the metastatic progression of prostate cancer

... of ECM/BM components, such as colla- gen types I, II, III and IV, laminin and fibronectin ...of ECM and display a disintegrin region that, by virtue of an RGD motif, play a role in cell- cell adhesion and ...

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Recent Advances in Tissue Engineering and
Regenerative Medicine

Recent Advances in Tissue Engineering and Regenerative Medicine

... The extracellular matrix (ECM) materials are used as a bio-ink but are limited largely to non-vascularized ...decellularized extracellular matrix (dECM) bio-inks are the recent ...

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Essential role of mitogen activated protein kinases in IL 17A induced MMP 3 expression in human synovial sarcoma cells

Essential role of mitogen activated protein kinases in IL 17A induced MMP 3 expression in human synovial sarcoma cells

... Abbreviations IL-17A: interleukin-17A; MMPs: matrix metalloproteinases; ECM: extracellular matrix; MAPK: mitogen-activated protein kinase; ERK1/2: extracellular signalregulated kinase ½;[r] ...

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