factor VIII inhibitors
Neutralizing antiidiotypic antibodies to factor VIII inhibitors after desensitization in patients with hemophilia A
... Hemophilia A patients producing antibodies towards FVIII are usually treated with infusions of high doses of FVIII in an attempt to “desensitize” them. To examine the mecha- nisms by which such desensitization operates, ...
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Prevalence of factor VIII inhibitors in haemophilia a patients who received factor VIII therapy
... of inhibitors was ...which inhibitors first developed or comment on the duration of their ...70. Factor VIII inhibitors rise in patients with haemophilia A throughout life with a ...
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Screening and quantitative estimation of factor VIII inhibitors by Nijmegen-Bethesda assay in hemophilia a patient of Southern Odisha, India
... spurious factor activation resulting in false ...of factor activity of labile factors ...time), Factor VIII assay were ...screen Factor VIII inhibitors and then the ...
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Treatment of Haemophilia A by Replacement Therapy using Factor VIII Inhibitors
... of factor VIII gene is spotted by the presence on the end of the lengthy arm of chromosomes ...the factor VIII is a polypeptide containing 2332 amino acids (inactivated flowing master ...
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Detection of Factor VIII Inhibitors in Hemophilia A Patients
... residual factor VIII activity on the y-axis ...of factor VIII in normal plasma after two hours of incubation at ...of inhibitors was taken as ...
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Molecular basis of factor VIII inhibition by human antibodies Antibodies that bind to the factor VIII light chain prevent the interaction of factor VIII with phospholipid
... to factor VIII have recently been shown to react with discrete regions of the factor VIII light chain (within the C2 domain) and/or the factor VIII heavy chain (within the ...
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Acquired factor VIII inhibitor and lupus anticoagulant presenting with prolonged aPTT: a case report
... Factor VIII inhibitors are mainly of the IgG subclass ...with factor VIII inhibitors [10–13] ...acquired factor VIII inhibitor and pregnancy which mainly presented ...
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Rituximab for Treatment of Hemophilia A with High-Responder Inhibitors
... formation against coagulation factor (20- 23). Some case reports and case series showed benefit of rituximab in high responder inhibitor in congenital hemophilia A (24-25). No randomized clinical trials were ...
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Rare and unusual case of anti-factor XI antibodies in patient with plasma cell leukemia
... coagulation factor which gener- ally expose to hemorrhagic ...acquired factor VIII inhibitors has been reported in 4 cases of MM with hemorrhagic manifestations; 2 men and 2 women, aged 43 to ...
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Stabilization of Factor VIII in Plasma by the von Willebrand Factor: STUDIES ON POSTTRANSFUSION AND DISSOCIATED FACTOR VIII AND IN PATIENTS WITH VON WILLEBRAND'S DISEASE
... of factor VIII (VIII AHF ) to that of the von Willebrand factor activity (ristocetin cofactor, VIII VWF ) or factor VIII antigen (VIII AGN ) is ~1, but ratios > ...
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Survival of 125iodine labeled Factor VIII in normals and patients with classic hemophilia Observations on the heterogeneity of human Factor VIII
... human Factor VIII was used to study its survival in normals and patients with classic hemophilia, and to study the heterogeneity of Factor VIII; Purified Factor VIII was ...
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Procoagulant factors and the risk of myocardial infarction in young women
... procedures. Factor VIII activity (VIII), factor IX activity (IX) and factor XI activity (XI) levels were measured by a one-stage clotting assay with factor VIII-, ...
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Understanding and Improving Platelet-Delivered Factor (F) VIII Hemostatic Efficacy in Hemophilia A Mice
... functional Factor (F) ...B-domainless factor VIII (phBF8) in the presence of circulating inhibitors in FVIIInull ...Willebrand Factor (vWF), efficiently, we tested the effectiveness of ...
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Many factor VIII products available in the treatment of hemophilia A: an embarrassment of riches?
... of factor VIII (FVIII) with an incidence of ~1 in 5000 male ...recombinant factor VIII single chain (rFVIII-SC). As development of inhibitors to FVIII continues to be a major problem in ...
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Recombinant Factor VIII versus plasma derived Factor VIII in the management of haemophilia A: an examination of the costs and consequences
... A further cost consideration for individual purchasers is the magnitude of the resource consequences for so called ‘big bleed episodes’ i.e. major bleeding episodes requiring considerable medical attention. These ...
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Adeno-Associated Viral Vector-Driven Expression of Coagulation Proteins for Treatment of Hemophilias and Cancer
... Gene therapy induced tolerance can also benefit a group of patients with genetic diseases, such as metabolic disorders like Pompe disease, where enzyme replacement therapies (ERT) currently on the market are ultimately ...
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The interaction of bovine factor VIII with human platelets
... bovine Factor VIII caused three types of aggregation: (a) primary agglutination; (b) secondary aggregation involving the platelet release reaction; and (c) super-aggregation, in which the platelets were ...
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The Subunit Structure of Normal and Hemophilic Factor VIII
... factor VIII. By sedimentation equilibrium analysis, the normal factor VIII subunit was homogeneous and had an estimated molecular weight of ...hemophilic factor VIII ...
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Intracellular trafficking of factor VIII to von Willebrand factor storage granules
... In plasma, von Willebrand factor (vWf) associates with Factor VIII (FVIII); however, the site at which these pro- teins first interact has not been defined. Administration of 1-desamino-8- D ...
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Donor antigen-primed regulatory T cells permit liver regeneration and phenotype correction in hemophilia A mouse by allogeneic bone marrow stem cells
... K/O factor VIII knockout, HA hemophilia A, HAT-A hemophilia A mice transplanted with allogeneic cells, HAT-AT hemophilia A mice transplanted with allogeneic and regulatory T cells, n number of mice in each ...
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