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Fatty Acid Desaturase 1

Fatty acid desaturase 1 knockout mice are lean with improved glycemic control and decreased development of atheromatous plaque

<em>Fatty acid desaturase 1</em> knockout mice are lean with improved glycemic control and decreased development of atheromatous plaque

... Delta-5 desaturase (D5D) and delta-6 desaturase (D6D), encoded by fatty acid desaturase 1 (FADS1) and FADS2 genes, respectively, are enzymes in the synthetic pathways for w3, w6, ...

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Menhaden oil, but not safflower or soybean oil, aids in restoring the polyunsaturated fatty acid profile in the novel delta-6-desaturase null mouse

Menhaden oil, but not safflower or soybean oil, aids in restoring the polyunsaturated fatty acid profile in the novel delta-6-desaturase null mouse

... sulfonic acid (w/v) (Fluka # 10417) under UV ...into acid washed test tubes already containing ...methylated fatty acids was extracted into a gas chromatography ...

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Comparative health-related fatty acid profiles, atherogenicity and desaturase indices of marula seed cake products from South Africa and Eswatini

Comparative health-related fatty acid profiles, atherogenicity and desaturase indices of marula seed cake products from South Africa and Eswatini

... Total lipid from MSC was quantitatively extracted according to the method of Folch et al. [45], using chloroform and methanol in a ratio of 2:1. An antioxidant, butylated hydroxytoluene was added at a ...

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Expression of a borage desaturase cDNA containing an N-terminal cytochrome b(5) domain results in the accumulation of high levels of Delta(6)-desaturated fatty acids in transgenic tobacco

Expression of a borage desaturase cDNA containing an N-terminal cytochrome b(5) domain results in the accumulation of high levels of Delta(6)-desaturated fatty acids in transgenic tobacco

... desaturase (1). Decreased activity of this key enzyme, ob- served for example in aging, stress, diabetes, eczema, and some infections, or increased catabolism of GLA resulting from oxidation or more rapid ...

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Polymorphisms in FADS1 and FADS2 alter plasma fatty acids and desaturase levels in type 2 diabetic patients with coronary artery disease

Polymorphisms in FADS1 and FADS2 alter plasma fatty acids and desaturase levels in type 2 diabetic patients with coronary artery disease

... influence desaturase activity and are associated with the risk of both T2D and CAD, which is consistent with previous reports [11, ...file 1: Table ...n-3 fatty acid concentrations in the ...

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Fatty acid desaturase (FADS) gene polymorphisms and insulin resistance in association with serum phospholipid polyunsaturated fatty acid composition in healthy Korean men: cross-sectional study

Fatty acid desaturase (FADS) gene polymorphisms and insulin resistance in association with serum phospholipid polyunsaturated fatty acid composition in healthy Korean men: cross-sectional study

... Our study has several limitations. First, study subjects were all healthy Korean men; thus, the results may not be applicable to women, other ethnic groups, or patients with cardiometablic syndrome whose lifestyle habits ...

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Molecular cloning of a functional Fads2 promoter from Zebrafish

Molecular cloning of a functional Fads2 promoter from Zebrafish

... of fatty acid desaturase 2 (FADS2) would be peroxisome proliferator-activated receptor α (PPARα) and sterol regulatory element-binding proteins 1c (SREBP-1c) ...polyunsaturated fatty acids ...

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Do ω-3 or other fatty acids influence the development of ‘growing pains’? A prebirth cohort study

Do ω-3 or other fatty acids influence the development of ‘growing pains’? A prebirth cohort study

... of fatty acids used in this paper are as follows: (1) the maternal prenatal dietary intake of ω -3 from seafood in late pregnancy using the data from food fre- quency questionnaires analysed in Hibbeln et ...

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Association of Bovine Fatty Acid Desaturase 2 Gene Single Nucleotide Polymorphisms with Intramuscular Fatty Acid Composition in Japanese Black Steers

Association of bovine fatty acid desaturase 2 gene single-nucleotide polymorphisms with intramuscular fatty acid composition in Japanese black steers

... oleic acid composition (C18:1 (n-9)), i.e., fatty acid synthase (FASN) [2], stea- royl-CoA desaturase (SCD) [3], and sterol regulatory element binding protein-1 (SREBP1) [4], ...

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A Cytochrome b5-Containing Plastid-Located Fatty Acid Desaturase from Chlamydomonas reinhardtii

A Cytochrome b5-Containing Plastid-Located Fatty Acid Desaturase from Chlamydomonas reinhardtii

... 100 ␮ l chloroform. Usually 10 ␮ l was converted to their fatty acyl methyl esters (FAMEs) as described previously (35). Lipids contained in 30 ␮ l were separated by thin-layer chromatography (TLC) (48), and MGDG ...

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Ethnicity, sex, FADS genetic variation, and hormonal contraceptive use influence delta-5- and delta-6-desaturase indices and plasma docosahexaenoic acid concentration in young Canadian adults: a cross-sectional study

Ethnicity, sex, FADS genetic variation, and hormonal contraceptive use influence delta-5- and delta-6-desaturase indices and plasma docosahexaenoic acid concentration in young Canadian adults: a cross-sectional study

... subjects (147 subjects) while the present study examined sex-specific associations in 786 subjects that met our in- clusion and exclusion criteria. Findings from the present study confirmed significant associations ...

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Increasing medium chain fatty acids production in Yarrowia lipolytica by metabolic engineering

Increasing medium chain fatty acids production in Yarrowia lipolytica by metabolic engineering

... (e.g. fatty acid desaturases [44]). The front-end desaturase dis- plays the motif variant QXXHH in which Q instead of H is an essential requirement for protein function ...

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Cytochrome b5 Coexpression Increases Tetrahymena thermophila Δ6 Fatty Acid Desaturase Activity in Saccharomyces cerevisiae

Cytochrome b5 Coexpression Increases Tetrahymena thermophila Δ6 Fatty Acid Desaturase Activity in Saccharomyces cerevisiae

... 6 desaturase activity, was transformed with the DES6c candidate desaturase expression ...with 1% dimethyl sulfoxide (DMSO) and 0.2 mM 18:2 ⌬9,12 fatty acid (Nu-Chek Prep; Ely- sian, ...

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ECTOPIC OVEREXPRESSION OF MUCACP-Δ9 DESATURASE LEADS TO Ω-7 FATTY ACID ACCUMULATION IN TOBACCO LEAVES

ECTOPIC OVEREXPRESSION OF MUCACP-Δ9 DESATURASE LEADS TO Ω-7 FATTY ACID ACCUMULATION IN TOBACCO LEAVES

... (ω-7) fatty acids, consisting of primarily palmitoleic acid (C16:1Δ9) and its elongation product, cis-vaccenic acid (C18:1Δ11), have unique features and are widely used in food, health care, as well ...

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An Evolutionary Relationship Between Stearoyl-CoA Desaturase (SCD) Protein Sequences Involved in Fatty Acid Metabolism

An Evolutionary Relationship Between Stearoyl-CoA Desaturase (SCD) Protein Sequences Involved in Fatty Acid Metabolism

... number of scd genes varies from one to five, and are generally called scd1, scd2, scd3, scd4, and scd5 in different organisms (7, 8). The evolutionary history revealed that the scd genes in vertebrates could be ...

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Plasma concentration of cis 9trans 11 CLA in males and females is influenced by SCD1 genetic variations and hormonal contraceptives: a cross-sectional study

Plasma concentration of cis 9trans 11 CLA in males and females is influenced by SCD1 genetic variations and hormonal contraceptives: a cross-sectional study

... palmitic acid but higher ste- aric acid levels in Caucasian women only; however, asso- ciations with [16:1/16:0] and [18:1/18:0] desaturase indices were not significant ...or ...

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The association of cardiovascular risk factors with saturated fatty acids and fatty acid desaturase indices in erythrocyte in middle-aged Korean adults

The association of cardiovascular risk factors with saturated fatty acids and fatty acid desaturase indices in erythrocyte in middle-aged Korean adults

... (Table 1). There were no significant differ- ences in the percentages of fatty acids in erythrocyte membrane phospholipids between men and women ex- cept for linoleic acid (LA, C18:2n6) and ...

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FADS1-FADS2 genetic polymorphisms are associated with fatty acid metabolism through changes in DNA methylation and gene expression

FADS1-FADS2 genetic polymorphisms are associated with fatty acid metabolism through changes in DNA methylation and gene expression

... of fatty acid levels in a Chinese population, we identified several strong sig- nals on the FADS region and confirmed the associations of polymorphisms in FADS gene cluster with decreased GLA, AA, ADA, EPA, ...

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Associations between estimated fatty acid desaturase activities in serum lipids and adipose tissue in humans: links to obesity and insulin resistance

Associations between estimated fatty acid desaturase activities in serum lipids and adipose tissue in humans: links to obesity and insulin resistance

... Fatty acid composition of serum lipids and adipose tissue triacylglycerols (AT-TAG) partly reflect dietary fatty acid ...The fatty acid composition is, besides the diet, also ...

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The Effect of Temperature on Fatty Acid Desaturase Gene Expression and Fatty Acid Composition in Developing Soybean Seeds.

The Effect of Temperature on Fatty Acid Desaturase Gene Expression and Fatty Acid Composition in Developing Soybean Seeds.

... Fatty acid desaturases (FADs) are essential for a number of physiological processes in ...Omega-3 fatty acid desaturases (FAD3s) catalyze the insertion of a third double bond into linoleic ...

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