fibroblast-like synoviocytes
Effect of 1,25 (OH)2D3 on proliferation of fibroblast like synoviocytes and expressions of pro inflammatory cytokines through regulating MicroRNA 22 in a rat model of rheumatoid arthritis
... unknown, fibroblast- like synoviocytes (FLS) have been reported to play a critical role in the pathogenesis of RA [3, ...synovial fibroblast interactions and inhibits synovial inflammation ...
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Characterisation of fibroblast like synoviocytes from a murine model of joint inflammation
... FLS: fibroblast-like synoviocytes; GM-CSF: granulocyte-macrophage colony-stimulating factor; ICAM-1: intercellular adhesion molecule 1; IgG: immunoglobulin G; IL: interleukin; PDGF: platelet-derived ...
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Evaluation of tendon healing using fibroblast like synoviocytes in rabbits: A biomechanical study
... Tendon never restores the complete biological and mechanical properties after healing. Several techniques are available for tissue-engineered biological augmentation for tendon healing like stem cells. Recently, ...
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Anti inflammatory and antiarthritic effects of piperine in human interleukin 1β stimulated fibroblast like synoviocytes and in rat arthritis models
... In this study, the anti-inflammatory effects of piperine were tested in IL1β-stimulated rheumatoid arthritis fibroblast-like synoviocytes derived from patients with rheumatoid arthritis.[r] ...
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PI3K/Akt inhibitor partly decreases TNF-α-induced activation of fibroblast-like synoviocytes in osteoarthritis
... It has been proposed that fibroblast-like synoviocytes (FLS) are actively involved in chronic inflammatory reactions. The molecular mechanisms of their sus- tained activation might be contributed to ...
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Glutaminase 1 plays a key role in the cell growth of fibroblast like synoviocytes in rheumatoid arthritis
... FLS: Fibroblast-like synoviocytes; GAPDH: Glyceraldehyde-3-phosphate dehydrogenase; GC/MS: Gas chromatography-mass spectrometry; GLS: Glutaminase; HK: Hexokinase; IL: Interleukin; LPS: ...
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Adiponectin may contribute to synovitis and joint destruction in rheumatoid arthritis by stimulating vascular endothelial growth factor, matrix metalloproteinase 1, and matrix metalloproteinase 13 expression in fibroblast like synoviocytes more than proinflammatory mediators
... arthritis fibroblast-like synoviocytes Next, to evaluate whether adiponectin stimulates the produc- tion of VEGF and MMPs for angiogenesis of pannus and joint destruction in RA FLSs, VEGF and MMP ...
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Endoplasmic reticulum stress cooperates with Toll like receptor ligation in driving activation of rheumatoid arthritis fibroblast like synoviocytes
... joint, fibroblast-like synoviocytes (FLS), exhibit an imprinted and epigenetically maintained aggressive phenotype, pre- disposing them to participate in an inflammatory positive feedback loop in ...
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In Vitro Evaluation of Equine Fibroblast-Like Synoviocytes Viability Treated with Doxycycline
... equine fibroblast-like synoviocytes viability, using the 3-(4,4-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide (MTT) reduction assay and trypan blue ...
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Characterisation of fibroblast-like synoviocytes from a murine model of joint inflammation
... FLS: fibroblast-like synoviocytes; GM-CSF: granulocyte-macrophage colony-stimulating factor; ICAM-1: intercellular adhesion molecule 1; IgG: immunoglobulin G; IL: interleukin; PDGF: platelet-derived ...
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PUMA mediated apoptosis in fibroblast like synoviocytes does not require p53
... PUMA (p53-upregulated modulator of apoptosis) is a pro- apoptotic gene that can induce rapid cell death through a p53- dependent mechanism. However, the efficacy of PUMA gene therapy to induce synovial apoptosis in ...
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RHAMM induces progression of rheumatoid arthritis by enhancing the functions of fibroblast like synoviocytes
... Rheumatoid arthritis (RA) is an immune-mediated disorder induced by chronic and refractory autoimmunity in the synovial joints, which leads to the damage of the cartilage and bone. RA affects approximately 1% of the ...
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The GTPase Rac Regulates the Proliferation and Invasion of Fibroblast-Like Synoviocytes from Rheumatoid Arthritis Patients
... Fibroblast-like synoviocytes (FLS) isolated from joints of rheumatoid arthritis (RA) patients display proliferative and invasive prop- erties reminiscent of those of malignant tumor ...
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The Sp1 transcription factor is essential for the expression of gliostatin/thymidine phosphorylase in rheumatoid fibroblast like synoviocytes
... sequences. Fibroblast-like synoviocytes were transiently transfected with deletion constructs and then incubated with mithramycin (100 nM, shaded column, or 300 nM, closed column) for 24 ...
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Regulatory effect of calcineurin inhibitor, tacrolimus, on IL 6/sIL 6R mediated RANKL expression through JAK2 STAT3 SOCS3 signaling pathway in fibroblast like synoviocytes
... FLS: fibroblast-like synoviocytes; H & E: hematoxylin and eosin; IL: interleukin; IFN: interferon; JAK2: Janus activated kinase; M-CSF: macrophage colony- stimulating factor; MNCs: mononuclear ...
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Resistin upregulates chemokine production by fibroblast like synoviocytes from patients with rheumatoid arthritis
... Methods: The expression of resistin and adenylate cyclase-associated protein 1 (CAP1), a receptor for resistin, was examined immunohistochemically in synovial tissue. CAP1 expression in in vitro cultured ...
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Innate immunity triggers IL 32 expression by fibroblast like synoviocytes in rheumatoid arthritis
... Figure 1 Effect of IFN-γ 0.1 ng/ml on IL-32 mRNA expression and IL-32 release by rheumatoid arthritis RA fibroblast-like synoviocytes FLSs.. e IL32 release in culture supernatants was de[r] ...
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Glucose 6 phosphate isomerase promotes the proliferation and inhibits the apoptosis in fibroblast like synoviocytes in rheumatoid arthritis
... Introduction: Fibroblast-like synoviocytes (FLS) play an important role in the pathogenesis of rheumatoid arthritis (RA). This study aimed to investigate the role of glucose 6-phosphate isomerase ...
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Expression of interleukin 18 receptor in fibroblast like synoviocytes
... Expression of intercellular adhesion molecule (ICAM)-1 in fibroblast- like synoviocytes (FLS) (a) and U937 cells (b) upon stimulation with IL-18 (x-axis: staining intensity; y-axis: number of ...
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MLN51and GM CSF involvement in the proliferation of fibroblast like synoviocytes in the pathogenesis of rheumatoid arthritis
... Rheumatoid arthritis (RA) is an inflammatory autoimmune disease of unclear etiology. This study was conducted to identify critical factors involved in the synovial hyperplasia in RA pathology. We applied cDNA microarray ...
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