Fibroblast-like synoviocytes rheumatoid arthritis
Anti inflammatory and antiarthritic effects of piperine in human interleukin 1β stimulated fibroblast like synoviocytes and in rat arthritis models
... Black pepper (Piper nigrum) is commonly used as a spice in human diets, but it is also used as a medicine, a preservative, and a perfume in many Asian countries. An extract of the active phenolic component, piperine, is ...
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MLN51and GM CSF involvement in the proliferation of fibroblast like synoviocytes in the pathogenesis of rheumatoid arthritis
... develops arthritis after immunization with heterologous or autologous type II collagen of rat, bovine or chick CII origin [32]. In addition, DCs are particularly relevant in the pathogen- esis of most inflammatory ...
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Akt activity protects rheumatoid synovial fibroblasts from Fas induced apoptosis by inhibition of Bid cleavage
... Cultured rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) were untreated (Basal), treated for 12 hours with 1 μg/ml anti-Fas antibody or pretreated for one hour with ...
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Effects of inflammatory cytokine IL 27 on the activation of fibroblast like synoviocytes in rheumatoid arthritis
... blast-like synoviocytes; ICAM: intercellular adhesion molecule; IFN: interferon; IL: interleukin; JAK: Janus kinase; JNK: c-Jun amino-terminal kinase; MAPK: mito- gen activated protein kinases; MFI: mean ...
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Innate immunity triggers IL 32 expression by fibroblast like synoviocytes in rheumatoid arthritis
... Figure 1 Effect of IFN-γ 0.1 ng/ml on IL-32 mRNA expression and IL-32 release by rheumatoid arthritis RA fibroblast-like synoviocytes FLSs.. e IL32 release in culture supernatants was de[r] ...
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Resistin upregulates chemokine production by fibroblast like synoviocytes from patients with rheumatoid arthritis
... Methods: The expression of resistin and adenylate cyclase-associated protein 1 (CAP1), a receptor for resistin, was examined immunohistochemically in synovial tissue. CAP1 expression in in vitro cultured ...
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The GTPase Rac Regulates the Proliferation and Invasion of Fibroblast-Like Synoviocytes from Rheumatoid Arthritis Patients
... Whereas the signaling pathways that mediate the role of Rac proteins in the control of RA-FLS proliferation remain to be identified, in this work we focused more on the mechanisms that are respon- sible for Rac-regulated ...
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Glucose 6 phosphate isomerase promotes the proliferation and inhibits the apoptosis in fibroblast like synoviocytes in rheumatoid arthritis
... Introduction: Fibroblast-like synoviocytes (FLS) play an important role in the pathogenesis of rheumatoid arthritis (RA). This study aimed to investigate the role of glucose 6-phosphate ...
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Different expression of β subunits of the KCa1 1 channel by invasive and non invasive human fibroblast like synoviocytes
... Background: Fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA-FLS) contribute to joint inflammation and damage characteristic of the ...
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Original Article Deoxycytidine kinase promotes the migration and invasion of fibroblast-like synoviocytes from rheumatoid arthritis patients
... [21, 22]. However, the role of DCK in the patho- genesis of RA has not been explored. The goal of this study was to investigate the role of DCK in regulating the migration and invasion of rheumatoid ...
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Long noncoding RNA expression profile in fibroblast like synoviocytes from patients with rheumatoid arthritis
... Interestingly, strong associations between ENST0000 0483588 expression and the CRP level and SDAI score in patients with RA were found. CRP is an important clinical parameter that is commonly used as a marker of disease ...
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Endoplasmic reticulum stress cooperates with Toll like receptor ligation in driving activation of rheumatoid arthritis fibroblast like synoviocytes
... in rheumatoid arthritis (RA), only a fraction of disease sus- ceptibility can be explained by genetic variation [1], and the temporal link between the break of self-tolerance and development of clinical ...
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Methotrexate inhibits effects of platelet derived growth factor and interleukin 1β on rheumatoid arthritis fibroblast like synoviocytes
... of fibroblast-like synoviocytes (FLS) was performed according to the protocol in ...in rheumatoid arthritis (RA) FLS (b) and in osteoarthritis (OA) FLS ...
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ADAM 17 is expressed on rheumatoid arthritis fibroblast like synoviocytes and regulates proinflammatory mediator expression and monocyte adhesion
... FLSs: Fibroblast-like synoviocytes; ICAM-1: Intercellular adhesion molecule 1; IL: Interleukin; NL: Normal; OA: Osteoarthritis; qPCR: Quantitative polymerase chain reaction; RA: Rheumatoid ...
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The Effect of Serum Carrying Total Flavonoids of Rhizoma Drynariae on the Proliferation and Apoptosis of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis
... Keywords: Rheumatoid Arthritis; Synovial Inflammation; Fibroblast; Rhizoma Drynariae Abbreviations: RA: Rheumatoid Arthritis; FLSs: Fibroblast-Like Synoviocytes; ...
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Fibroblast activation protein is expressed by rheumatoid myofibroblast like synoviocytes
... Rheumatoid arthritis (RA) is a chronic inflammatory disease of unknown aetiology and is characterised by hyperplasia and chronic inflammation of the synovial membranes that invade deeply into the articular ...
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A novel function of artesunate on inhibiting migration and invasion of fibroblast like synoviocytes from rheumatoid arthritis patients
... Rheumatoid arthritis (RA) is a common chronic inflam- matory disease characterized by synovitis, leading to the destruction of the articular cartilage and bone ...in fibroblast-like ...
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Effect of 1,25 (OH)2D3 on proliferation of fibroblast like synoviocytes and expressions of pro inflammatory cytokines through regulating MicroRNA 22 in a rat model of rheumatoid arthritis
... Rheumatoid arthritis (RA), affecting ...unknown, fibroblast- like synoviocytes (FLS) have been reported to play a critical role in the pathogenesis of RA [3, ...synovial ...
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Adiponectin may contribute to synovitis and joint destruction in rheumatoid arthritis by stimulating vascular endothelial growth factor, matrix metalloproteinase 1, and matrix metalloproteinase 13 expression in fibroblast like synoviocytes more than proinflammatory mediators
... in rheumatoid arthritis fibroblast-like synoviocytes Next, to evaluate whether adiponectin stimulates the produc- tion of VEGF and MMPs for angiogenesis of pannus and joint destruction ...
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Glutaminase 1 plays a key role in the cell growth of fibroblast like synoviocytes in rheumatoid arthritis
... FLS: Fibroblast-like synoviocytes; GAPDH: Glyceraldehyde-3-phosphate dehydrogenase; GC/MS: Gas chromatography-mass spectrometry; GLS: Glutaminase; HK: Hexokinase; IL: Interleukin; LPS: ...
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