FLICE inhibitory protein
Herpes Simplex Virus Type 1 (HSV-1)-Induced Apoptosis in Human Dendritic Cells as a Result of Downregulation of Cellular FLICE-Inhibitory Protein and Reduced Expression of HSV-1 Antiapoptotic Latency-Associated Transcript Sequences
... Herpes simplex virus type 1 (HSV-1) is one of the most frequent and successful human pathogens. It targets immature dendritic cells (iDCs) to interfere with the antiviral immune response. The mechanisms underlying ...
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Internal Ribosome Entry Site Regulates Translation of Kaposi's Sarcoma-Associated Herpesvirus FLICE Inhibitory Protein
... viral FLICE inhibitory protein v-FLIP (K13, ...endogenous protein in latently infected KSHV-positive primary effusion lymphoma (PEL) cell ...
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Integrated microarray and multiplex cytokine analyses of Kaposi's Sarcoma Associated Herpesvirus viral FLICE Inhibitory Protein K13 affected genes and cytokines in human blood vascular endothelial cells
... K13 protein is one of the few proteins to be expressed in latently-infected spindle ...viral FLICE inhibitory protein (vFLIP), K13 was subsequently shown to be a potent acti- vator of the ...
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Kaposi's sarcoma associated herpes virus encoded viral FLICE inhibitory protein activates transcription from HIV 1 Long Terminal Repeat via the classical NF κB pathway and functionally cooperates with Tat
... K13 protein contains two homologous copies of a Death Effector Domain (DED) that is also present in the prodomains of caspase 8 (also known as FLICE), caspase 10 and cellular FLICE Inhibitory ...
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Deletion of Kaposi's Sarcoma-Associated Herpesvirus FLICE Inhibitory Protein, vFLIP, from the Viral Genome Compromises the Activation of STAT1-Responsive Cellular Genes and Spindle Cell Formation in Endothelial Cells
... cific lymphatic endothelial genes, including VEGFR3, podo- planin, LYVE1, and Prox-1, in dermal microvascular endothelial cells upon KSHV infection (11). The K13 latent viral gene (also referred to as open reading frame ...
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Down-regulation of cellular FLICE-inhibitory protein (Long Form) contributes to apoptosis induced by Hsp90 inhibition in human lung cancer cells
... binding protein homologous protein-dependent death receptor 5 induction and ubiquitin/proteasome-mediated cellular FLICE-inhibitory protein down-regulation contribute to enhancement of ...
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Hepatitis C Virus Core Protein Inhibits Tumor Necrosis Factor Alpha-Mediated Apoptosis by a Protective Effect Involving Cellular FLICE Inhibitory Protein
... adapter protein TNFR1-associated death domain protein (TRADD), which in turn recruits TNF receptor-associated factor 2, recep- tor-interacting protein, and Fas-associated death domain pro- tein ...
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Cells of the synovium in rheumatoid arthritis Synovial fibroblasts
... A major factor contributing to synovial growth is the resis- tance of RASF against apoptosis, which can be linked to distinct anti-apoptotic molecules such as FLICE inhibitory protein (FLIP) and ...
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Caspases: pharmacological manipulation of cell death
... Death domains are 80- to 100-residue-long motifs Nonstandard abbreviations used: BIR, baculoviral IAP repeat; CARD, caspase recruitment domain; c-FLIP, cellular FLICE-inhibitory protein;[r] ...
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Selective Inhibition of FLICE-like Inhibitory Protein (FLIP) Expression With Small Interfering RNA Oligonucleotides (siRNAs) Is Sufficient to Sensitize Tumor Cells for TRAIL-Induced Apoptosis
... cellular FLICE- inhibitory protein (cFLIP) has been identified as a major cellular inhibitor of apoptosis induced by TRAIL-R1/2 and other death receptors ...
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The Growth-hormone inducible transmembrane protein (Ghitm) belongs to the Bax inhibitory protein-like family
... predicted protein topology indicates that they are transmembrane proteins of the type 3a with a variable number of transmembrane spanners from six to eight localized in the endoplasmatic ...
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Isolation of Ipomoea Batatas Protein and Characterization of Amylase Inhibitory Activity
... Crude protein content in sweet potatoes has been reported to range from ...of protein from 100 ml of sweet potato homogenate based on wet ...of protein from this extraction procedure, resulting in a ...
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Compounds inhibitory to rat liver 5α-reductase from tropical commercial wood species: resveratrol trimers from melapi (Shorea sp.) heartwood
... The protein content of microsomes was determined by a Bio-rad protein assay kit (catalog no. To isolate 5a-reductase inhibitory components, extrac- tion was done o[r] ...
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Inhibition of insulin degradation by nonsuppressible insulin like activity
... RESULTS A comparison of the insulin-like activity in microunits per milligram protein with the insulin degrading inhibitory activity expressed as percent inhibition per milligram protein[r] ...
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Bradykinin activated membrane associated phospholipase C in Madin Darby canine kidney cells
... nucleotide-binding protein in receptor-mediated activation of PLC, we evaluated the role of guanine nucleotide proteins in receptor-mediated (bradykinin-stimulated) activation of PLC in MDCK ...cell protein ...
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Cytomegalovirus e127 Protein Interacts with the Inhibitory CD200 Receptor
... transmembrane protein with 56% amino acid sequence identity with rat CD200 ...recombinant protein was constructed with the two IgSF domains of RCMV e127 coupled to CD4 domains 3 and 4 as an antigenic tag ...
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Distinct activation mechanisms of NF κB regulator inhibitor of NF κB Kinase (IKK) by isoforms of the Cell Death Regulator Cellular FLICE like Inhibitory Protein (cFLIP)*
... cells was validated by immunoblotting. From five independent shRNAs used to silence each protein, two that yielded the most efficient knockdowns were chosen for the experiments. Targeted sequences for each gene ...
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The role of bacterial antizyme: From an inhibitory protein to AtoC transcriptional regulator
... Az1 protein to be expressed ...another protein called "anti-antizyme", which liberates ODC in the presence of growth stimuli having higher affinity for Az1 than for ODC ...
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PHYSIOCHEMICAL PROPERTIES AND ACE INHIBITORY CAPACITY OF HAZELNUT PROTEIN ISOLATE AND HYDROLYSATES
... Emulsifying activity index (EAI) and emulsifying stability index (ESI) of HPI at pH 7 were found as 44 m 2 /g and 46 min, respectively. Polar, non-polar and non- charged polar structures of proteins together have both ...
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Angiotensin I-converting Enzyme (ACE) Inhibitory Activity of ACE Inhibitory Peptides Produced during the Fermentation of Pigeon Pea (Cajanus cajan) Tempe
... addition, protein of pigeon pea contains high amounts of hydrophobic amino acids such as phenylalanine, leucine, valine, isoleucine, proline and negatively charged amino acids (Oshodi et al, 1993; Solomon et ...
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