FLSs, fibroblast-like synoviocytes
Resistin upregulates chemokine production by fibroblast like synoviocytes from patients with rheumatoid arthritis
... serum; FLSs: Fibroblast-like synoviocytes; GAPDH: Glyceraldehyde-3-phosphate dehydrogenase; IL: Interleukin; mAb: Monoclonal antibody; MMP: Matrix metalloproteinase; OA: Osteoarthritis; pAb: ...
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Evaluation of tendon healing using fibroblast like synoviocytes in rabbits: A biomechanical study
... intratendinously at both tendon stumps just next to incision line in FLSs treated group. Rabbits in control group underwent the same surgical procedures, except that they just received the equal volume of PBS ...
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promotes cell migration and has been implicated in arterial tissue-repair processes. Furthermore, high CTHRC1 expression is observed in many types of cancer and this is
... Rheumatoid synoviocytes, which consist of fibroblast-like synoviocytes (FLSs) and synovial macrophages (SMs), are crucial for the progression of rheumatoid arthritis (RA) as they form ...
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The antifibrotic drug pirfenidone inhibits spondyloarthritis fibroblast-like synoviocytes and osteoblasts in vitro
... SpA FLSs. Our finding of decreased proliferation in SpA FLSs is in line with previous studies showing inhibition of proliferation of fibroblasts from lung, striated muscle, heart and eye [22, 23, 32, ...
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Effect of taurine chloramine on the production of matrix metalloproteinases (MMPs) in adiponectin- or IL-1β-stimulated fibroblast-like synoviocytes
... vitro, fibroblast-like synovio- cytes (FLSs) were cultured and stimulated with adipo- nectin (10 µg/ml) or IL-1 b (10 ng/ml) in the presence or absence of 600 µM TauCl ...mulated FLSs as shown ...
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Fibroblast activation protein is expressed by rheumatoid myofibroblast like synoviocytes
... by fibroblast-like synoviocytes (FLSs) and compared the synovial expression pattern in rheumatoid arthritis (RA) and osteoarthritis (OA) ...result, FLSs from intensively inflamed ...
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MLN51and GM CSF involvement in the proliferation of fibroblast like synoviocytes in the pathogenesis of rheumatoid arthritis
... develops arthritis after immunization with heterologous or autologous type II collagen of rat, bovine or chick CII origin [32]. In addition, DCs are particularly relevant in the pathogen- esis of most inflammatory ...
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Innate immunity triggers IL 32 expression by fibroblast like synoviocytes in rheumatoid arthritis
... Human FLSs were isolated from synovial tissues from four different RA and OA (osteoarthritis) patients at the time of knee-joint arthroscopic synovectomy, as described previously ...Normal FLSs were ...
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In Vitro Evaluation of Equine Fibroblast-Like Synoviocytes Viability Treated with Doxycycline
... Synovial fluid samples were aspirated with syringes containing sodium heparin (Heparodic, Caspiantamin, Gilan, Iran) from metacarpophalangeal joints using aseptic techniques from six skeletally mature (4-7 years old) ...
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Adiponectin may contribute to synovitis and joint destruction in rheumatoid arthritis by stimulating vascular endothelial growth factor, matrix metalloproteinase 1, and matrix metalloproteinase 13 expression in fibroblast like synoviocytes more than proinflammatory mediators
... is a single nonglycosylated polypeptide chain produced in Escherichia coli with a molecular weight of 25.1 kDa and con- taining 231 amino acids. Thus, the adiponectin used in this system may not completely duplicate the ...
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Extracellular heat shock protein 70 inhibits tumour necrosis factor α induced proinflammatory mediator production in fibroblast like synoviocytes
... have anti-inflammatory effects on RA, which might partly be due to downregulation of proinflammatory mediators by FLSs. However, HSP70 has also been shown to induce proinflam- matory cytokines such as TNF-α, IL-1 ...
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Chemerin activates fibroblast like synoviocytes in patients with rheumatoid arthritis
... RA FLSs and chemerin itself activate FLSs to enhance the production of IL-6 and ...RA FLSs, leading to persistent amplification of inflammation in the RA synovium, possibly in an auto- crine or ...
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Are mesenchymal stem cells in rheumatoid arthritis the good or bad guys?
... damage. Like MSCs, fibroblast-like synoviocytes (FLSs) are part of the stroma of the synovial ...RA, FLSs undergo proliferation and contribute to the formation of the deleterious ...
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Apoptosis is not the major death mechanism induced by celecoxib on rheumatoid arthritis synovial fibroblasts
... arthritis fibroblast-like synoviocytes (RA FLSs). (a) FLSs were stimulated for 2 hours with celecoxib at indicated concentrations or for 4 hours with tumor necrosis factor-related ...
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Interaction with hyaluronan matrix and miRNA cargo as contributors for in vitro potential of mesenchymal stem cell-derived extracellular vesicles in a model of human osteoarthritic synoviocytes
... human fibroblast-like synoviocytes (FLSs) from OA ...OA FLSs with intact or digested HA matrix were co-cultured with fluorescent ASC-EVs, and incorporation scored by flow cytometry and ...
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Diosgenin, a plant steroid, induces apoptosis in human rheumatoid arthritis synoviocytes with cyclooxygenase 2 overexpression
... (RA) fibroblast-like synoviocytes (FLS) Diagram summarizing major events in diosgenin-induced apoptosis in human rheumatoid arthritis (RA) fibroblast-like synoviocytes ...
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The Ras guanine nucleotide exchange factor RasGRF1 promotes matrix metalloproteinase 3 production in rheumatoid arthritis synovial tissue
... Evidence is now emerging that altered expression of Ras GEFs may contribute to autoimmune diseases. Mice lacking expression of the Ras GEF Ras guanine nucleotide-releasing protein 1 develop a spontaneous systemic lupus ...
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RHAMM induces progression of rheumatoid arthritis by enhancing the functions of fibroblast like synoviocytes
... The pathogenesis of RA remains to be completely eluci- dated, but it is well known that FLS play a key role in it. Normally,synovial fibroblasts line the joints, but in RA they are increased in numbers as part of the ...
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Anti inflammatory and antiarthritic effects of piperine in human interleukin 1β stimulated fibroblast like synoviocytes and in rat arthritis models
... In this study, the anti-inflammatory effects of piperine were tested in IL1β-stimulated rheumatoid arthritis fibroblast-like synoviocytes derived from patients with rheumatoid arthritis.[r] ...
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PI3K/Akt inhibitor partly decreases TNF-α-induced activation of fibroblast-like synoviocytes in osteoarthritis
... Given the important roles uncovered for PI3K in pro- moting inflammation, many studies have investigated the effects of pharmacological inhibition of PI3K iso- forms in animal models of inflammatory joint disease. The ...
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