FLT3-TKD
Frequency of FLT3 ITD and FLT3 TKD Mutations in Multiple Myeloma Patients (A Case Control Study)
... Different FLT3 activating mutations have been detected, but two types are more common as described in detail previously [3, 10]; 1) internal tandem duplication (ITD) which is seen in 15- 35% of adult patients with ...
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FLT3 inhibitors: clinical potential in acute myeloid leukemia
... 1) FLT3-ITD receptors are efficiently targeted by TKI (T) but bypass activation of oncogenic tyrosine kinases (SYK or AXL) or serine/threonine kinases (Pim) reduce the activity of TKi and enhance AML cell ...
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Gilteritinib: a novel FLT3 inhibitor for acute myeloid leukemia
... Among the 371 patients, 247 were randomized to gilter- itinib and 124 to salvage chemotherapy [34]. The median age of the 371 patients was 62 years (range 19–85). Among the FLT3 mutations, 88.4% were ...
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FLT3 Mutations: Significance in Paediatric AML
... mentioned, FLT3 mutations are the most common and clinically relevant mutations in AML, contributing to around one-third of the ...of FLT3 receptor ...of FLT3 receptor, which results in the ...
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Absence of FLT3 mutations in Iranian adult T-cell leukemia/lymphoma patients
... Background lymphotropic v selectable traits Despite the int nancies. FMS l kemic patients been studied ye Methods: In February 2017 chloroform pro FLT3/TKD mu variables, respe were considere Results: No ...
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SU11652 Inhibits tyrosine kinase activity of FLT3 and growth of MV-4-11 cells
... of FLT3 have been found in about 30% of AML patients ...is FLT3-ITD caused by internal tan- dem duplication (ITD) in the juxtamembrane domain, and the less common FLT3-TKD type involves point ...
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Reindl, Carola (2007): Aberrante Aktivierung der Rezeptortyrosinkinase FLT3 in der akuten myeloischen Leukämie. Dissertation, LMU München: Medizinische Fakultät
... 1997). FLT3 wird aufgrund einer sterischen Hinderung durch ein nicht- konserviertes Phenylalanin (F691) nicht inhibiert (Bohmer, ...auch FLT3 hemmt. Eine Phase-II-Studie mit AML-Patienten, die eine ...
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Mobilization of CD34+ Progenitor Cells in Association with Decreased Proliferation in the Bone Marrow of Macaques after Administration of the Fms-Like Tyrosine Kinase 3 Ligand
... during FLT3-L ...after FLT3-L administration. Moreover, serum levels of FLT3-L did not correlate with ab- solute numbers of CD34 ⫹ cells in BM, which is in contrast to the linear relationships ...
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Correlation between roundhouse kick and countermovement jump performance
... Band al chagi (roundhouse kick) is one of the most used kicking techniques and can be defined as a semi-circular kick performed with foot dor- sum on the abdomen height of the opponent [5]. Falco et al. [6] in another ...
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FBP17 and CIP4 recruit SHIP2 and lamellipodin to prime the plasma membrane for fast endophilin mediated endocytosis
... HSS118094 (2 oligos against human FNBP1), set 3: Thermo HSS118095 (2 oligos against human FNBP1); CIP4 set 1: Thermo HSS113814 (2 oligos against human TRIP10), set 2: Thermo HSS190195 (2 oligos against human TRIP10), set ...
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Association of the EGF-TM7 receptor CD97 expression with FLT3-ITD in acute myeloid leukemia
... in FLT3 mutated MV4-11 and MOLM-13 cells in vitro confirmed our findings from the patient ...with FLT3 wildtype expression like EOL-1 and HL-60, but also normal CD34+ HSPCs (not shown) displayed low CD97 ...
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<p>Long Noncoding RNA SOCS2-AS Promotes Leukemogenesis in FLT3-ITD+ Acute Myeloid Leukemia Through miRNA-221</p>
... FLT3-ITD, STAT5 drives a wide spectrum of the pathogenesis of AML. High pY-STAT5 levels are found to be involved with prognosis in myeloid malignancies and TKI-resistance. 21 Several STAT5 inhibitors with ...
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Editorial: JCCA Special Issue December 2016 –Sports Chiropractic
... This study was a longitudinal retrospective study of Poomsae injuries sustained by the Canadian National Taekwondo team over a three-year period at the World Poomase Competition. Every member of the national team ...
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FLT3 inhibitors in acute myeloid leukemia
... with FLT3/ITD-positive AML. In a retrospective analysis, 17 patients with FLT3/ITD-positive AML re- ceived sorafenib in combination with allo-HSCT ...with FLT3/ITD-- mutated ...with ...
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The MERTK/FLT3 inhibitor MRX-2843 overcomes resistance-conferring FLT3 mutations in acute myeloid leukemia
... to FLT3 inhibition, the effects of inhibitors such as quizartinib have been well described, with myelosuppression being one of the most prominent toxicities, likely due to the com- bined inhibition of both ...
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Health through martial arts training: Physical fitness and reaction time in adolescent Taekwondo practitioners
... regular TKD training. The partici- pating TKD-trained teenagers had a faster simple reac- tion time in the ruler-drop test than their untrained coun- ...after TKD training [13] and in ...
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Study and application on the factors of attacking effect by TKD downward kick based on the influence of dynamic model
... On analyzing the data collected from the players’ training, some defects were found out when the players were downward kicking: it takes so long time to start and draw back the leg durin[r] ...
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Abundance of Flt3 and its ligand in astrocytic tumors
... Intermediate expression of ligand in astrocytic tumors would have a functional impact only in the presence of its corresponding receptor, ie, Flt3. However, the abundance of the receptor mRNA turned out to be much ...
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DRUG DESIGNING FOR TARGETING FLT3 RECEPTOTTYROSINE KINASE FOR LEUKEMIA DISEASE
... or FLT3, and this latter designation has emerged as the term most commonly used to describe both murine and human ...Human FLT3 maps to chromosome 13 (13q12) and is comprised of 24 exons extending over more ...
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Attenuation of vaccinia virus by the expression of human Flt3 ligand
... Human FL shares high homology with mouse FL in themino acid sequence, mainly in the extracellular part of the molecule, and is able to activate mouse Flt3 receptor [21]. The human Flt3L gene encodes a 235-amino ...
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