Follicular helper T cell
How Germinal Centers Evolve Broadly Neutralizing Antibodies: the Breadth of the Follicular Helper T Cell Response
... Tfh cell clonotypes and vary the mechanism whereby Tfh cells rescue germinal center B cells, we make other simplifying assumptions in order to develop a manageable model with different antigen ...B cell ...
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CD4+ follicular helper T cell infiltration predicts breast cancer survival
... Closer examination of the SN+S effect on TCR/CD3 pathway genes (Figure 6, G and H, and Supplemental Table 4) detected (a) significant suppression of various signaling genes that was more pronounced than that in the S ...
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Follicular helper T cell signature in type 1 diabetes
... of T cell differentiation as a Th1/Th2 dichotomy, with Th1 cells responsible for tissue-specific autoimmunity, has led numerous researchers to hunt for a Th1 signature in T1D, with widely variable ...memory ...
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T follicular helper cells in human efferent lymph retain lymphoid characteristics
... assess cell viabil- ity was added with an antibody cocktail diluted in FACS buffer (FACS buffer was replaced by media for sorting experiments) to stain for surface markers for an additional 20 ...B cell ...
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Circulating T follicular regulatory and helper cells have memory like properties
... of mice immunized with NP-OVA or NP-HEL, then cultured the sorted cells with Tfh and B cells from dLNs of mice immunized with NP-OVA. We added NP-OVA to the wells to stimulate linked recognition. Both NP-OVA– and ...
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Streptococcal superantigen‐induced expansion of human tonsil T cells leads to altered T follicular helper cell phenotype, B cell death and reduced immunoglobulin release
... tonsil cell function was ...Tonsil cell proliferation was quanti- ied by tritiated thymidine incorporation, and cell surface characteristics assessed by low ...Tonsil T cells proliferated in ...
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CD57+ T-cells are a subpopulation of T-follicular helper cells in nodular lymphocyte predominant Hodgkin lymphoma
... CD57+ cells in tonsil as well as in the areas around the tumor cells and the LP rosetting cells express BCL-6 in concurrence with previous studies about the pres- ence of BCL-6+ LP rosetting T-cells [4, 10]. A ...
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Expansion of HIV specific T follicular helper cells in chronic HIV infection
... CD4 T cells, which are required for the induction of high-affinity antibody responses and the formation of long-lived B cell ...CD4 T cells during HIV infection is therefore believed to impede the ...
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Distribution of distinct subsets of circulating T follicular helper cells in Kawasaki disease
... To investigate the importance of cTfh-cell subsets in KD, PBMCs isolated from KD patients in different stages and HCs were immunostained for CD3, CD4, CXCR5, CD45RA, CD183 and CD196 and subsequently analyzed using ...
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Changes in Follicular Helper T Cells in Idiopathic Thrombocytopenic Purpura Patients
... Using the criterion of the International Working Group of ITP defined in 2009 [23], we analyzed 23 patients diagnosed with chronic ITP in the Depart- ment of Hematology at our hospital. The clinical and laboratory ...
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Understanding pathogenic and physiological T follicular helper cell formation
... CD80 expression on B cells regulates murine T follicular helper development, _germinal center B cell survival, and plasma cell generation.. B cells and TCR avidity determine distinct fun[r] ...
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Crucial Roles of Interleukin-7 in the Development of T Follicular Helper Cells and in the Induction of Humoral Immunity
... enhanced T cell receptor (TCR) repertoire diversity (27) as well as increased frequency of Tfh cells by IL-7 cotreatment during ...for T cell activation ...epitope-specific T cells by ...
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A High Frequency of HIV Specific Circulating Follicular Helper T Cells Is Associated with Preserved Memory B Cell Responses in HIV Controllers
... B cell responses are actually strong in HIV controllers and are thus discon- nected from circulating NAb ...B cell enzyme-linked immunosorbent spot assays (ELISpot) (40, 55–57) or on direct labeling with ...
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Survivin co-ordinates formation of follicular T-cells acting in synergy with Bcl-6
... Follicular T helper cells (Tfh) is a subtype of memory T cells residing in secondary lymphoid structures, germinal centers (GC), and regulating B cell maturation and antibody ...their ...
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Interplay of Il-4, Il-21, and Ifnγ on Memory B Cell Fate Decisions
... factor, T-BET, has been implicated in reinforcing BMEM cells of the IgG2c ...driving T-BET and CD11c expression remain poorly defined. T follicular helper (TFH) cells instruct B cells ...
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CD4 T Cell Help Is Limiting and Selective during the Primary B Cell Response to Influenza Virus Infection
... CD4 T cell re- sponse: how it develops into memory, and how it may support future primary B cell responses to heterologous ...CD4 T cell memory with the capacity to robustly expand in ...
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Original Article T follicular helper cells in peripheral blood are associated with the expression of B cells and plasma IgE level in patients with acute asthma exacerbation
... [13] Avery DT, Deenick EK, Ma CS, Suryani S, Simp- son N, Chew GY, Chan TD, Palendira U, Busta- mante J, Boisson-Dupuis S, Choo S, Bleasel KE, Peake J, King C, French MA, Engelhard D, Al-Hajjar S, Al-Muhsen S, Magdorf K, ...
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Lethal Coinfection of Influenza Virus and Streptococcus pneumoniae Lowers Antibody Response to Influenza Virus in Lung and Reduces Numbers of Germinal Center B Cells, T Follicular Helper Cells, and Plasma Cells in Mediastinal Lymph Node
... bacterial cell counts and decreased the level of virus-specific IgG, IgM, and IgA, as well as the number of B cells, CD4 T cells, and plasma ...the follicular developmental ...cells, T ...
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A critical role of T follicular helper cells in human mucosal anti-influenza response that can be enhanced by immunological adjuvant CpG-DNA.
... cells (>98%). Unfractionated MNC or CD45RO+cell-depleted MNC were cultured (4x10 6 /ml) in 96-well flat-bottom culture plates in RPMI-1640 medium with HEPES supplemented with 10% fetal bovine serum (FBS), 1% ...
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Increased Circulating T Follicular Helper Cells in Iranian Children with Type I Diabetes
... years, T follicular helper (Tfh) cells have been recognized as a subpopulation of CD4 + T cells that required for germinal center formation, B cells differentiation and antibody ...B ...
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