From Tissue to Whole Body Insulin Resistance
Myocardial insulin resistance does not always parallel skeletal muscle and whole body insulin resistance: A mini review—Myocardial Insulin Resistance
... Positron emission tomography (PET) has emerged as a new clinical diagnostic tool that allows non-invasive quantitative analysis in several human tissue metabo- lisms and blood flow in vivo. In principle, PET has ...
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Four‑Stage Evolution of Diabetes or Whole Body Insulin Resistance (WBIR): Debunking of the Lipid‑Induced Insulin Resistance (LIIR) and Proposing of the Glycation‑Induced Insulin Resistance (GIIR)
... diabetes from rapid weight gain to visceral obesity to rapid weight loss to full-blown diabetic state seems to comply rather well with the natural development history of diabetes ...that tissue-specific IRs ...
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Effects of bariatric surgery on whole body and femoral adipose tissue insulin sensitivity
... obesity. This unusual situation provided a unique opportunity to compare metabolic and bariatric surgery.These findings suggests that the name and, by inference, the intent of metabolic/diabetes surgery may influence ...
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Segmentation and Evaluation of Adipose Tissue from Whole Body MRI Scans
... adipose tissue. Such a procedure needs to be done once for one whole body MRI ...adipose tissue in the image, a prior. From the segmented sample tissue, a more accurate ...
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Insulin resistance causes inflammation in adipose tissue
... We next tested whether the increase in MCP1 is responsible for M1 macrophage accumulation in AdRiKO eWAT. Mice were fed a HFD for 8 weeks and then treated with an MCP1-neutral- izing or control antibody for 2 weeks along ...
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Bone specific insulin resistance disrupts whole body glucose homeostasis via decreased osteocalcin activation
... USA. Insulin signaling in osteoblasts has been shown recently to contribute to whole-body glucose homeostasis in animals fed a normal diet; however, it is unknown whether bone contributes to the ...
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Bone-specific insulin resistance disrupts whole-body glucose homeostasis via decreased osteocalcin activation
... USA. Insulin signaling in osteoblasts has been shown recently to contribute to whole-body glucose homeostasis in animals fed a normal diet; however, it is unknown whether bone contributes to the ...
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Independent tissue contributors to obesity-associated insulin resistance
... Methods Study population. In this randomized controlled trial with blinded analyses, 53 abdominally obese and 25 lean men were recruited by advertisements and enrolled at the Maastricht University Medi- cal Center in ...
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Atherogenic lipids profile relates to postprandial hyperglycemia and hyperinsulinemia due to whole body insulin resistance in prediabetic subjects
... A possible explanation for the difference between IGT and IFG in level of association with CVD is differences in serum lipids profile in addition to the differences in plasma peak levels of glucose and/or insulin. ...
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Changes in total and segmental bioelectrical resistance are correlated with whole-body and segmental changes in lean soft tissue following a resistance training intervention
... The body composition and bioelectrical assessments were well- standardized to reduce confounding factors such as ex- ercise, caffeine, pre-testing dietary intake, and changes in hydration ...DXA-derived ...
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Insulin resistance in obesity: body-weight or energy balance?
... glycerol from adipocytes into the circulation in the obese state is one of the major factors responsible for IR (Ferraninni et ...acids from an enlarged fat mass leads to both an increase in oxidation of ...
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Tissue specific insulin resistance in mice with mutations in the insulin receptor, IRS 1, and IRS 2
... circulating insulin levels between ir/irs-1 +/– and ir/irs-2 +/– mice, we analyzed islet morphology in mice of various ...5b). Insulin levels correlated with increased β-cell mass in all groups of ...
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Prediction of whole body fat percentage and visceral adipose tissue mass from five anthropometric variables
... error from the regression equa- tion (standard error of the estimate; ...value from a regression equation—is obtained from the one- tailed area under the t-distribution for the appropriate degrees of ...
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Prediction of whole-body fat percentage and visceral adipose tissue mass from five anthropometric variables
... VAT can be quantified with confidence using imaging modalities such as abdominal com- puted tomography (CT). However, due to high radiation exposure and cost implications, CT is not ideal for large-scale screening or ...
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Natural killer T cells in adipose tissue prevent insulin resistance
... the insulin resistance observed in CD1d-null mice? LFD-fed CD1d-null mice showed none of the pathological alterations associated with liver-mediated insulin ...muscle tissue, another key ...
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Mechanisms of Insulin Resistance after Immunosuppressive Therapy in Brown Adipose Tissue
... The development of brown adipocytes are mainly controlled by two essential transcriptional factors known as peroxisome proliferator-activated receptor γ (PPARγ) and PGC1α, which induce adipogenesis and enhance the ...
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Brown adipose tissue–specific insulin receptor knockout shows diabetic phenotype without insulin resistance
... both insulin action and in insulin secretion (1, ...eral insulin resistance has been demonstrated in mus- cle, WAT, and liver; however, little is known about the potential role of ...
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Special issue: Molecular mechanisms of insulin resistance in peripheral tissues Metabolic and molecular mechanisms of macrophage polarisation and adipose tissue insulin resistance
... Fatty acid transporters (FATP1) and fatty acid binding proteins (FABP4/5) also influence mac- rophage polarisation (95,96). Macrophage-deficiency of FATP1 biases cellular respiration to- wards glycolysis and primes ...
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The Effects of Circuit Resistance Training on Inflammatory Status, Insulin Resistance and Body Composition in Overweight Adolescent Boys
... as insulin resistance and obesity ...to body fat, some of which suggest a relationship (49), whereas the other studies indicate no relationship ...
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Adiposity mediates the association between whole grain consumption, glucose homeostasis and insulin resistance: findings from the US NHANES
... adipose tissue is known to secrete a number of pro-inflammatory adipokines, including tumor necrosis factor a, IL-6 and Plasminogen activator inhibitor-1 (PAI-1) ...data from 4700 adults aged 20–90 years, ...
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