G2-M DNA damage checkpoint
UV Irradiation Causes the Loss of Viable Mitotic Recombinants in Schizosaccharomyces pombe Cells Lacking the G2/M DNA Damage Checkpoint
... pair DNA repair mediated by homologous recombina- Strains: Genotypes of the strains used in this study are shown tion and may link cell cycle checkpoints to the activation in Table ...
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Cytotoxicity, anti-angiogenic, apoptotic effects and transcript profiling of a naturally occurring naphthyl butenone, guieranone A
... leukemia CCRF-CEM (0.73 μ g/ml) and its resistant subline CEM/ADR5000 (1.01 μ g/ml) and on lung adenocarcinoma A549 (0.72 μ g/ml) cell lines were closer or lower than that of doxorubicin. Interestingly, low cytotoxicity ...
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The SFP1 Gene Product of Saccharomyces cerevisiae Regulates G2/M Transitions During the Mitotic Cell Cycle and DNA-Damage Response
... The G2 damage checkpoint has been analyzed in de- gle and Hartwell ...as DNA-damage ...single-stranded DNA [the in vivo generation of excess 1995; Elledge ...single-stranded ...
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Overexpression of the Drosophila ATR homologous checkpoint kinase Mei-41 induces a G2/M checkpoint in Drosophila imaginal tissue
... Fig. 4 Cell cycle re-entry is delayed in cells overexpressing mei-41. (a) The indicated kinase or the lacZ control was overexpressed in the posterior compartment of wing imaginal discs using en-Gal4-GFP. Third instar ...
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RBX1/ROC1-SCF E3 ubiquitin ligase is required for mouse embryogenesis and cancer cell survival
... abnormal DNA damage response is involved in later stage death of RBX1/p27 double null ...triggers DNA damage response and checkpoint controls via modulating the levels of oncogenes or ...
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Role of garlic derived Allyl sulfide in inducing g2/m checkpoint arrest and apoptosis
... the G2/M ...to DNA damage (Danhua Xiao et ...from G2 phase of the cellcycle into mitosis depending on the activated or inactivated form of Cdk1/CyclinB ...the G2/M ...
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Working hard for recovery: mitotic kinases in the DNA damage checkpoint
... damage checkpoint, indicating an essential involvement of Plk1 inhibition in checkpoint activation ...how DNA damage leads to Plk1 inhibition dur- ing G2/M ...that ...
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Early G2/M checkpoint failure as a molecular mechanism underlying etoposide induced chromosomal aberrations
... cycle checkpoint is 1 of the conceivable risk factors in MLL- rearranged ...early G2/M checkpoint pathway could act as a predisposing condition for acquiring chromosome ...early ...
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Suppressors of Cdc25p Overexpression Identify Two Pathways That Influence the G2/M Checkpoint in Fission Yeast
... the DNA damage checkpoint re- Rad25p, and Chk1p function in concert with the protein sponse of the double mutants by evaluating their survival kinase Cds1p in the checkpoint response to ...
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Antagonism of Chk1 Signaling in the G2 DNA Damage Checkpoint by Dominant Alleles of Cdr1
... to DNA damage and is not as sensitive to Chk1 overexpression as the dominant-negative cdr1 ...c M illan et ...regulate DNA damage re- sponses, although the DNA damage ...
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NSCLC cells demonstrate differential mode of cell death in response to the combined treatment of radiation and a DNA- PKcs inhibitor
... of DNA-PKcs contributes to processing and direct ligation of broken DNA ...in DNA DSB repair, DNA-PKcs also participates in DNA DSB-induced G2/M cell cycle ...
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Sinularin induces DNA damage, G2/M phase arrest, and apoptosis in human hepatocellular carcinoma cells
... DNA damage induced by anti-cancer drugs can initiate p53-dependent and p53-independent pathways to block cells at the G2/M checkpoint and from entry into mitosis by which drugs can ...
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Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival
... a DNA-damaging chemotherapeutic drug, activates p38 MAPK, but pharmacological and genetic inhibition of this path- way enhances the apoptotic effect of etoposide ...to DNA damage stimuli activa- tion ...
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The conservation of genotoxic stress-induced morphological changes in yeasts
... the DNA integrity checkpoints are the highly conserved ...When DNA damage is detected by sensor proteins Mec1 and Tel1, which signal through mediator Rad9 to downstream effectors Rad53 and Chk1 [7] ...
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Targeting WEE1 to enhance conventional therapies for acute lymphoblastic leukemia
... of DNA damage. The combination also perturbed the G2/ M checkpoint as evidenced by the combined effect on reducing phospho-CDC2 (Tyr15) in comparison with the single ...of DNA ...
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Cell cycle checkpoint in cancer: a therapeutically targetable double-edged sword
... the G2/M checkpoint, Wee1 kinase controls proper timing of mitosis onset by perform- ing inhibitory phosphorylation of Cdk1 ...extensive DNA damage, micronuclei forma- tion and ...
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RAC1 GTPase plays an important role in γ irradiation induced G2/M checkpoint activation
... IR-induced DNA damage involves activation of ATM and ATR signaling, which results in activation of the Wee1 kinase that phosphorylates Cdc2- Tyr15 and inhibition of the Cdc25 phosphatase that ...
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Checkpoint kinase inhibitor AZD7762 strongly sensitises urothelial carcinoma cells to gemcitabine
... Upon DNA damage caused by chemotherapy, checkpoints respond to DNA damage by arresting the cell cycle to pro- vide time for DNA ...repair. Checkpoint signalling following ...
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<p>UBE2T promotes proliferation via G2/M checkpoint in hepatocellular carcinoma</p>
... the G2/M ...and G2/M ...in G2/M ...of G2/ M ...of G2/M ...regulates G2/M transition through cyclin B1 and CDK1; however, the exact ...
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PubMedCentral-PMC5837509.pdf
... In conclusion, this study provides an analysis of HTS and genomics-based data on a compound that is of high interest from the regulatory perspective. Emerging methods were used to evaluate the HTS data, including mapping ...
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