Galectin-3 inhibitor
Galectin-3 Activation and Inhibition in Heart Failure and Cardiovascular Disease: An Update
... Although galectin-3 has been implicated in several debilitating disorders, only a few galectin-3 inhibitors have been developed that are of clinical ...develop galectin-3 ...
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Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis
... circulating galectin-3 promote dissemination of tumour cell metastatic spread to remote sites ...The galectin-3-MUC1/4 interaction induces MUC1/4 cell surface polarization and results in the ...
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Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis
... circulating galectin-3 promote dissemination of tumour cell metastatic spread to remote sites ...The galectin-3-MUC1/4 interaction induces MUC1/4 cell surface polarization and results in the ...
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The role of Galectin-3 in α-synuclein-induced microglial activation
... the galectin-3 inhibitor for 12 h or genetic down-regulation using siRNA we found a significant down-regulation in different pro- inflammatory molecules that include iNOS and TNF-α, molecules ...
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Galectin 3 Inhibits Galectin 8/Parkin Mediated Ubiquitination of Group A Streptococcus
... Galectins are synthesized as cytosolic proteins, but they can also be secreted from cells via a nonclassical pathway. Through binding to glycans, galectins modulate multiple cellular functions (38–40). In bacterial ...
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Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis
... 5 Figure S1: Sub-fractionation of the modified heparin derivatives. A: E, F and G were subfractionated on a Sephadex G-100 column (26mm x 1000 mm) in 0.5M ammonium bicarbonate on an AKTA Purifier 10 (GE Life Sciences). ...
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Labeling galectin-3 for the assessment of myocardial infarction in rats
... residues. These residues, however, are prone to deiodina- tion after in vivo administration [28] and generally result in low label stability and loss of free iodide. Thus, the high thyroid uptake described points to ...
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Kraft, Franziska (2018): Expression von Sialyl Lewis a, Sialyl Lewis x, Lewis y, Galectin-3, Galectin-7, Stathmin 1 und p16 in Gewebeproben der zervikalen Dysplasie. Dissertation, LMU München: Medizinische Fakultät
... Als weitere Behandlungsmöglichkeiten erweisen sich lokal destruktive Therapien. Dazu zählen die radical diathermy, die Diathermiekoagulation, die Laservaporisation, die Kryotherapie und die cold coagulation. Bei der ...
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Treatment of B-cell precursor acute lymphoblastic leukemia with the Galectin-1 inhibitor PTX008
... (Sigma cat M4287) for 3 h in complete medium. Selected lots of FBS that supported the co-culture included JR Scientific cat 43,640 lot K051–6; Life Technologies cat 16,140,071 lot 1,642,038 US Qual HI; and Atlanta ...
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Immunohistochemical Expression of Galectin-3 and CD56 in Thyroid Neoplasms and Its Histopathological Correlation
... As to the CD56 positivity found in the 2 cases of papillary carcinoma, one case was classical type of papillary carcinoma showing 3+ CD56 positivity in 60% of the tumor cells. Nearly 40% of the tumor cells showed ...
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Serum Apelin and Galactin-3 in Preeclampsia in Iraq Aamal Sattar Taha 1,2 , Zohreh Zahraei 1* , Hussein Kadhem Al-Hakeim 3
... The venous blood samples of pregnant women were aspirated without tourniquet into plain tubes, allowed to stand for 10 min for coagulation and then separated through centrifugation at 3,000 × g for 5 min. Sera were ...
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Differential regulation of fibroblast growth factor receptor 1 trafficking and function by extracellular galectins
... response. Galectin-1 efficiently induced phospho- rylation of FGFR1 and downstream signaling proteins: kinase ERK1/2 and PLCγ in a concentration-dependent manner and to a similar extent as FGF1 ...lanes ...
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<p>Galectin-3 as a prognostic biomarker for diabetic nephropathy</p>
... Extracellular galectin-3 interacts with the β -galactoside residues of extracellular matrix and cell surface glycoproteins via its C-terminal carbohydrate-recogni- tion ...intracellular ...
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“Utility of Plasma Galectin-3, a Novel Marker of Fibrosis, for Evaluation of Syrian Patients with chronic Heart Failure” by MounaKhaity, Faizeh Al-Quobaili, Syria.
... divided galectin-3 plasma levels ...ng/mL). Galectin-3 levels in dyspneic patients without HF were ...IV: 3- ...were 3- ...
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Original Article The inactive form of glycogen synthase kinase-3β is associated with the development of carcinomas in galectin-3 wild-type mice, but not in galectin-3-deficient mice
... increased galectin-3 expression in RKO-gal3 cells is associated with increased levels of AKT protein, P-GSK3β-Ser9 and beta-catenin, an important mediator of the Wnt signaling pathway ...
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Alteration of Galectin-3 in Tears of Patients With Dry Eye Disease
... of galectin-3 have been detected in pathological conditions and have been shown to inhibit a variety of processes such as tumor growth and wound ...Importantly, galectin-3C has a much higher binding ...
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Galectin-3: a possible complementary marker to the PSA blood test
... PCa. Galectin-3 can be cleaved by MMP-2, MMP-9 between Ala 62 – Tyr 63, as well as by PSA between Tyr 107- Gly ...extracellular galectin-3 should be cleaved either after alanine 62 or tyrosine ...
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Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis
... of galectin-3-mediated cancer cell-endothelial adhesion, these derivatives were tested for their impact on circulating galectin-3-mediated metastasis in an experimental mouse metastasis ...
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Over expression of cytosolic galectin 3 correlates with anti apoptotic protein bcl 2: its significance in the differential diagnosis of follicular cell derived thyroid tumors in fnac
... Primer 3 software and the nucleotide sequence were synthesised from Sigma Aldrich, Bangalore, ...follows: Galectin-3: sense 5' ATGCAAACAGAATTGC TTTAGATT3', antisense 5' ...
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Original Article Galectin-3: a novel protein in cerebellar hemangioblastoma
... ‘‘HIF-1α, Galectin-3, VEGF, VEGFR, WT-1, and bcl2,’’ ...with galectin-3 and VEGF as well as galectin-3 with VEGF in stromal cells is confirmed by im- munofluorescent ...of ...
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